ethyl 2-amino-4,5-dimethyl-3-thiophenecarboxylate -Drug Synthesis Database

【结构式】

【分子编号】18107

【品名】ethyl 2-amino-4,5-dimethyl-3-thiophenecarboxylate

【CA登记号】4815-24-1

【分子式】C₉H₁₃NO₂S

【分子量】199.27376

【元素组成】C 54.25% H 6.58% N 7.03% O 16.06% S 16.09%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号：(I)

Condensation of aminothiophene (I) with cyclohexyl isocyanate (II) in refluxing toluene afforded urea (III). Then, treatment with ethanolic KOH gave the pyrimidine dione system.

参考文献中间体

合成目标

【1】 Romeo, G.; et al.; Synthesis of new thieno[2,3-d]pyrimidine-2,4(1H, 3H)-diones with analgesic and anti-inflammatory activities. Arzneim-Forsch Drug Res 1998, 48, 2, 167-172.

中间体序号	中间体编号	品名	CAS号	分子式	供应商	用于合成
(I)	18107	ethyl 2-amino-4,5-dimethyl-3-thiophenecarboxylate	4815-24-1	C₉H₁₃NO₂S	详情	详情
(II)	18108	1-isocyanatocyclohexane; cyclohexyl isocyanate	3173-53-3	C₇H₁₁NO	详情	详情
(III)	18109	ethyl 2-[[(cyclohexylamino)carbonyl]amino]-4,5-dimethyl-3-thiophenecarboxylate		C₁₆H₂₄N₂O₃S	详情	详情

Extended Information