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【结 构 式】 
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【药物名称】 【化学名称】3-Cyclohexyl-5,6-dimethylthieno[2,3-d]pyrimidine-2,4(1H,3H)-dione 【CA登记号】203808-33-7 【 分 子 式 】C14H18N2O2S 【 分 子 量 】278.37576 |
【开发单位】Università degli Studi di Catania (Originator) 【药理作用】ANALGESIC AND ANESTHETIC DRUGS, Analgesic Drugs, Non-Opioid Analgesics, Non-Steroidal Antiinflammatory Drugs |
合成路线1
Condensation of aminothiophene (I) with cyclohexyl isocyanate (II) in refluxing toluene afforded urea (III). Then, treatment with ethanolic KOH gave the pyrimidine dione system.
| 【1】 Romeo, G.; et al.; Synthesis of new thieno[2,3-d]pyrimidine-2,4(1H, 3H)-diones with analgesic and anti-inflammatory activities. Arzneim-Forsch Drug Res 1998, 48, 2, 167-172. |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 18107 | ethyl 2-amino-4,5-dimethyl-3-thiophenecarboxylate | 4815-24-1 | C9H13NO2S | 详情 | 详情 |
| (II) | 18108 | 1-isocyanatocyclohexane; cyclohexyl isocyanate | 3173-53-3 | C7H11NO | 详情 | 详情 |
| (III) | 18109 | ethyl 2-[[(cyclohexylamino)carbonyl]amino]-4,5-dimethyl-3-thiophenecarboxylate | C16H24N2O3S | 详情 | 详情 |
Extended Information