5-(chloromethyl)-4-methyl-1,3-oxazole -Drug Synthesis Database

【结构式】

【分子编号】15740

【品名】5-(chloromethyl)-4-methyl-1,3-oxazole

【CA登记号】

【分子式】C₅H₆ClNO

【分子量】131.56148

【元素组成】C 45.65% H 4.6% Cl 26.95% N 10.65% O 12.16%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号：(VIII)

2) Alkylation of the tetrahydropyridoindolone (VII) with 5-chloromethyl-4-methyloxazole (VIII) in dimethoxyethane in the presence of sodium hydride affords (IX). Ammonolysis of this material is carried out by heating with formamide.

参考文献中间体

合成目标

【1】 Oxford, A.W.; Hagan, R.M.; Tyers, M.B.; Kilpatrick, G.J.; North, P.C.; GR-68755 Hydrochloride. Drugs Fut 1992, 17, 8, 660.

中间体序号	中间体编号	品名	CAS号	分子式	供应商	用于合成
	53911	1-Methyl-1-phenylhydrazine; 1-Methylphenylhydrazine	618-40-6	C₇H₁₀N₂	详情	详情
(V)	15737	dihydro-2,4(1H,3H)-pyridinedione		C₅H₇NO₂	详情	详情
(VI)	15738	4-[(Z)-methyl(phenyl)-lambda(5)-azanylidene]dihydro-2(1H,3H)-pyridinone		C₁₂H₁₆N₂O	详情	详情
(VII)	15739	5-methyl-2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indol-1-one		C₁₂H₁₂N₂O	详情	详情
(VIII)	15740	5-(chloromethyl)-4-methyl-1,3-oxazole		C₅H₆ClNO	详情	详情
(IX)	15741	5-methyl-2-[(4-methyl-1,3-oxazol-5-yl)methyl]-2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indol-1-one		C₁₇H₁₇N₃O₂	详情	详情

Extended Information