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【结 构 式】 
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【分子编号】15738 【品名】4-[(Z)-methyl(phenyl)-lambda(5)-azanylidene]dihydro-2(1H,3H)-pyridinone 【CA登记号】 |
【 分 子 式 】C12H16N2O 【 分 子 量 】204.27192 【元素组成】C 70.56% H 7.89% N 13.71% O 7.83% |
与该中间体有关的原料药合成路线共 1 条
合成路线1
该中间体在本合成路线中的序号：(VI)2) Alkylation of the tetrahydropyridoindolone (VII) with 5-chloromethyl-4-methyloxazole (VIII) in dimethoxyethane in the presence of sodium hydride affords (IX). Ammonolysis of this material is carried out by heating with formamide.
| 【1】 Oxford, A.W.; Hagan, R.M.; Tyers, M.B.; Kilpatrick, G.J.; North, P.C.; GR-68755 Hydrochloride. Drugs Fut 1992, 17, 8, 660. |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| 53911 | 1-Methyl-1-phenylhydrazine; 1-Methylphenylhydrazine | 618-40-6 | C7H10N2 | 详情 | 详情 | |
| (V) | 15737 | dihydro-2,4(1H,3H)-pyridinedione | C5H7NO2 | 详情 | 详情 | |
| (VI) | 15738 | 4-[(Z)-methyl(phenyl)-lambda(5)-azanylidene]dihydro-2(1H,3H)-pyridinone | C12H16N2O | 详情 | 详情 | |
| (VII) | 15739 | 5-methyl-2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indol-1-one | C12H12N2O | 详情 | 详情 | |
| (VIII) | 15740 | 5-(chloromethyl)-4-methyl-1,3-oxazole | C5H6ClNO | 详情 | 详情 | |
| (IX) | 15741 | 5-methyl-2-[(4-methyl-1,3-oxazol-5-yl)methyl]-2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indol-1-one | C17H17N3O2 | 详情 | 详情 |
Extended Information