【结 构 式】 |
【分子编号】15739 【品名】5-methyl-2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indol-1-one 【CA登记号】 |
【 分 子 式 】C12H12N2O 【 分 子 量 】200.24016 【元素组成】C 71.98% H 6.04% N 13.99% O 7.99% |
与该中间体有关的原料药合成路线共 3 条
合成路线1
该中间体在本合成路线中的序号:(VII)2) Alkylation of the tetrahydropyridoindolone (VII) with 5-chloromethyl-4-methyloxazole (VIII) in dimethoxyethane in the presence of sodium hydride affords (IX). Ammonolysis of this material is carried out by heating with formamide.
【1】 Oxford, A.W.; Hagan, R.M.; Tyers, M.B.; Kilpatrick, G.J.; North, P.C.; GR-68755 Hydrochloride. Drugs Fut 1992, 17, 8, 660. |
中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
---|---|---|---|---|---|---|
53911 | 1-Methyl-1-phenylhydrazine; 1-Methylphenylhydrazine | 618-40-6 | C7H10N2 | 详情 | 详情 | |
(V) | 15737 | dihydro-2,4(1H,3H)-pyridinedione | C5H7NO2 | 详情 | 详情 | |
(VI) | 15738 | 4-[(Z)-methyl(phenyl)-lambda(5)-azanylidene]dihydro-2(1H,3H)-pyridinone | C12H16N2O | 详情 | 详情 | |
(VII) | 15739 | 5-methyl-2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indol-1-one | C12H12N2O | 详情 | 详情 | |
(VIII) | 15740 | 5-(chloromethyl)-4-methyl-1,3-oxazole | C5H6ClNO | 详情 | 详情 | |
(IX) | 15741 | 5-methyl-2-[(4-methyl-1,3-oxazol-5-yl)methyl]-2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indol-1-one | C17H17N3O2 | 详情 | 详情 |
合成路线2
该中间体在本合成路线中的序号:(VII)
【1】 Coates IH, North PC, Oxford AW. 1989. Preparation of(imidazolylmethyl) oxoheterocycloindoles as 5-HT3 antagonists, EP 306323 |
中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
---|---|---|---|---|---|---|
(VII) | 15739 | 5-methyl-2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indol-1-one | C12H12N2O | 详情 | 详情 | |
(XVI) | 66072 | 4-methyl-2,3-dihydrocyclopenta[b]indol-1(4H)-one oxime | C12H12N2O | 详情 | 详情 | |
(XVII) | 66074 | 4-ethyl-5-methyl-1-(phosphinomethyl)-1H-imidazole | C7H13N2P | 详情 | 详情 | |
(XVIII) | 66073 | 4-methyl-2,3-dihydrocyclopenta[b]indol-1(4H)-one | C12H11NO | 详情 | 详情 |
合成路线3
该中间体在本合成路线中的序号:(VII)
【1】 Zhu ZH,Li RD.2001.Synthesis of alosetron hydrochloride.中国医药工业杂志,32(6):246-247 |
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