|
【结 构 式】 
|
【分子编号】15397 【品名】tert-butyl acetate 【CA登记号】540-88-5 |
【 分 子 式 】C6H12O2 【 分 子 量 】116.16008 【元素组成】C 62.04% H 10.41% O 27.55% |
合成路线1
该中间体在本合成路线中的序号：(XXIII)2) The condensation of the previously described aldehyde (XI) with (S)-(+)-2-acetoxy-1,1,2-triphenylethanol (XX) by means of lithium diisopropylamide (LDA) in THF gives 5-[2-(4-fluorophenyl)-5-isopropyl-3-phenyl-4-(N-phenylcarbamoyl)pyrrol-1-yl]-3(R)-hydroxypentanoic acid 2-hydroxy-1(S),2,2-triphenylethyl ester (XXI), which is trans-esterified with sodium methoxide in methanol/THF yielding the expected methyl ester (XXII). The condensation of (XXII) with tert-butyl acetate (XXIII) by means of LDA in THF affords (R)-7-[2-(4-fluorophenyl)-5-isopropyl-3-phenyl-4-(N-phenylcarbamoyl) pyrrol-1-yl]-5-hydroxy-3-oxoheptanoic acid tert-butyl ester (XXIV), which is reduced with triethylborane and NaBH4 in THF, hydrolyzed with NaOH, lactonized by heating in refluxing toluene and finally submitted to fractional crystallization in order to separate the two diastereomers of the obtained lactone, (R,R) and (R,S). The (R,R)-diastereomer (XIX), already obtained, is finally treated with NaOH and then with CaCl2.
| 【1】 Roth, B.D.; Blankley, C.J.; Chucholowski, A.W.; Ferguson, E.; Hoefle, M.L.; Ortwine, D.F.; Newton, R.S.; Sekerke, C.S.; Sliskovic, D.R.; Stratton, C.D.; Wilson, M.W.; Inhibitors of cholesterol biosynthesis. 3. Tetrahydro-4-hydroxy-6-[2-(1H-pyrrol-1-yl)ethyl]-2H-pyran-2-one inhibitors of HMG-CoA reductase. 2. Effects of introducing substituents at positions three and four of the pyrrole nucleus. J Med Chem 1991, 34, 1, 357-66. |
| 【2】 Graul, A.; Castaner, J.; Atorvastatin Calcium. Drugs Fut 1997, 22, 9, 956. |
| 【3】 Roth, B.D. (Pfizer Inc.); (R-(R*R*)-2-(4-Fluorophenyl)-beta,delta-dihydroxy-5-(1-methylethyl-3 -phenyl-4-[(phenylamino)-carbonyl]-1H-pyrrole-1-heptanoic acid, its lactone form and salts thereo. EP 0409281; JP 1991058967; US 5273995 . |
| 【4】 Mills, N.; Muhammad, N.A.; Weiss, J.; Nesbitt, R.U. (Pfizer Inc.); Stable oral CI-981 formulation and process for preparing same. EP 0680320; JP 1996505640; US 5686104; WO 9416693 . |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (XI) | 15386 | 5-(4-fluorophenyl)-2-isopropyl-1-(3-oxopropyl)-N,4-diphenyl-1H-pyrrole-3-carboxamide | C29H27FN2O2 | 详情 | 详情 | |
| (XIX) | 15391 | 5-(4-fluorophenyl)-1-[2-[(2R,4R)-4-hydroxy-6-oxotetrahydro-2H-pyran-2-yl]ethyl]-2-isopropyl-N,4-diphenyl-1H-pyrrole-3-carboxamide | C33H33FN2O4 | 详情 | 详情 | |
| (XX) | 11540 | (1S)-2-hydroxy-1,2,2-triphenylethyl acetate; (R)-(+)-1,1,2-Triphenyl-1,2-ethanediol 2-acetate | 95061-47-5 | C22H20O3 | 详情 | 详情 |
| (XXI) | 15395 | (1S)-2-hydroxy-1,2,2-triphenylethyl (3R)-5-[3-(anilinocarbonyl)-5-(4-fluorophenyl)-2-isopropyl-4-phenyl-1H-pyrrol-1-yl]-3-hydroxypentanoate | 134394-96-0 | C51H47FN2O5 | 详情 | 详情 |
| (XXII) | 15396 | methyl (3R)-5-[3-(anilinocarbonyl)-5-(4-fluorophenyl)-2-isopropyl-4-phenyl-1H-pyrrol-1-yl]-3-hydroxypentanoate | C32H33FN2O4 | 详情 | 详情 | |
| (XXIII) | 15397 | tert-butyl acetate | 540-88-5 | C6H12O2 | 详情 | 详情 |
| (XXIV) | 15398 | tert-butyl (5R)-7-[3-(anilinocarbonyl)-5-(4-fluorophenyl)-2-isopropyl-4-phenyl-1H-pyrrol-1-yl]-5-hydroxy-3-oxoheptanoate | C37H41FN2O5 | 详情 | 详情 |
合成路线2
该中间体在本合成路线中的序号：(IX)The synthesis of atorvastatin [14C]-labeled on the side chain has been described: The reaction of [14C]-labeled sodium acetate (I) with phthaloyl chloride (II) in refluxing xylene gives the acyl chloride (III), which is treated with 1,2,2-triphenyl-1(S),2-ethanediol (IV) in dichloromethane yielding the expected monoacetate (V). The condensation of (V) with the pyrrolepropionaldehyde (VI) by means of lithium diisopropylamide (LDA) in THF affords the chiral beta-hydroxyester (VII), which is transesterified with sodium methoxide in methanol providing the corresponding methyl ester (VIII). The condensation of (VIII) with tert-butyl acetate (IX) by means of LDA in THF gives the beta-oxo-delta-hydroxyester (X), which is regioselectively reduced to the dihydroxyester (XI) by means of BEt3, NaBH4 and H2O2 in THF. The hydrolysis of (XI) with NaOH in THF/water, followed by acidification yields the free acid (XII), which is heated in refluxing toluene in a Dean-Stark trap to provide lactone (XIII). The reaction of (XIII) with NaOH in THF/methanol gives the corresponding sodium salt (XIV), which is finally treated with CaCl2 in the same solvent.
| 【1】 Woo, P.W.K.; Lee, H.T.; Atorvastatin, an HMG-CoA reductase inhibitor and effective lipid-regulating agent. Part II. Synthesis of side-chain-labeled [C-14] atorvastatin. J Label Compd Radiopharm 1999, 42, 2, 129. |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 27912 | Sodium acetate | 127-09-3 | C2H3NaO2 | 详情 | 详情 |
| (I) | 45240 | sodium acetate | C2H3NaO2 | 详情 | 详情 | |
| (II) | 23811 | phthaloyl dichloride;1,2-Benzenedicarbonyl dichloride;o-Phthaloyl chloride | 88-95-9 | C8H4Cl2O2 | 详情 | 详情 |
| (III) | 19273 | acetyl chloride | 75-36-5 | C2H3ClO | 详情 | 详情 |
| (III) | 45241 | acetyl chloride | C2H3ClO | 详情 | 详情 | |
| (IV) | 27913 | (2S)-1,1,2-triphenyl-1,2-ethanediol | 95061-46-4 | C20H18O2 | 详情 | 详情 |
| (V) | 11540 | (1S)-2-hydroxy-1,2,2-triphenylethyl acetate; (R)-(+)-1,1,2-Triphenyl-1,2-ethanediol 2-acetate | 95061-47-5 | C22H20O3 | 详情 | 详情 |
| (V) | 45242 | (1S)-2-hydroxy-1,2,2-triphenylethyl acetate | C22H20O3 | 详情 | 详情 | |
| (VI) | 15386 | 5-(4-fluorophenyl)-2-isopropyl-1-(3-oxopropyl)-N,4-diphenyl-1H-pyrrole-3-carboxamide | C29H27FN2O2 | 详情 | 详情 | |
| (VII) | 15395 | (1S)-2-hydroxy-1,2,2-triphenylethyl (3R)-5-[3-(anilinocarbonyl)-5-(4-fluorophenyl)-2-isopropyl-4-phenyl-1H-pyrrol-1-yl]-3-hydroxypentanoate | 134394-96-0 | C51H47FN2O5 | 详情 | 详情 |
| (VII) | 45243 | (1S)-2-hydroxy-1,2,2-triphenylethyl (3R)-5-[3-(anilinocarbonyl)-5-(4-fluorophenyl)-2-isopropyl-4-phenyl-1H-pyrrol-1-yl]-3-hydroxypentanoate | C51H47FN2O5 | 详情 | 详情 | |
| (VIII) | 15396 | methyl (3R)-5-[3-(anilinocarbonyl)-5-(4-fluorophenyl)-2-isopropyl-4-phenyl-1H-pyrrol-1-yl]-3-hydroxypentanoate | C32H33FN2O4 | 详情 | 详情 | |
| (VIII) | 45244 | methyl (3R)-5-[3-(anilinocarbonyl)-5-(4-fluorophenyl)-2-isopropyl-4-phenyl-1H-pyrrol-1-yl]-3-hydroxypentanoate | C32H33FN2O4 | 详情 | 详情 | |
| (IX) | 15397 | tert-butyl acetate | 540-88-5 | C6H12O2 | 详情 | 详情 |
| (X) | 15398 | tert-butyl (5R)-7-[3-(anilinocarbonyl)-5-(4-fluorophenyl)-2-isopropyl-4-phenyl-1H-pyrrol-1-yl]-5-hydroxy-3-oxoheptanoate | C37H41FN2O5 | 详情 | 详情 | |
| (X) | 45245 | tert-butyl (5R)-7-[3-(anilinocarbonyl)-5-(4-fluorophenyl)-2-isopropyl-4-phenyl-1H-pyrrol-1-yl]-5-hydroxy-3-oxoheptanoate | C37H41FN2O5 | 详情 | 详情 | |
| (XI) | 27914 | tert-butyl (3R,5R)-7-[3-(anilinocarbonyl)-5-(4-fluorophenyl)-2-isopropyl-4-phenyl-1H-pyrrol-1-yl]-3,5-dihydroxyheptanoate | C37H43FN2O5 | 详情 | 详情 | |
| (XI) | 45246 | tert-butyl (3R,5R)-7-[3-(anilinocarbonyl)-5-(4-fluorophenyl)-2-isopropyl-4-phenyl-1H-pyrrol-1-yl]-3,5-dihydroxyheptanoate | C37H43FN2O5 | 详情 | 详情 | |
| (XII) | 15390 | (3R,5R)-7-[3-(anilinocarbonyl)-5-(4-fluorophenyl)-2-isopropyl-4-phenyl-1H-pyrrol-1-yl]-3,5-dihydroxyheptanoic acid | C33H35FN2O5 | 详情 | 详情 | |
| (XII) | 45247 | (3R,5R)-7-[3-(anilinocarbonyl)-5-(4-fluorophenyl)-2-isopropyl-4-phenyl-1H-pyrrol-1-yl]-3,5-dihydroxyheptanoic acid | C33H35FN2O5 | 详情 | 详情 | |
| (XIII) | 15391 | 5-(4-fluorophenyl)-1-[2-[(2R,4R)-4-hydroxy-6-oxotetrahydro-2H-pyran-2-yl]ethyl]-2-isopropyl-N,4-diphenyl-1H-pyrrole-3-carboxamide | C33H33FN2O4 | 详情 | 详情 | |
| (XIII) | 45248 | 5-(4-fluorophenyl)-1-[2-[(2R,4R)-4-hydroxy-6-oxotetrahydro-2H-pyran-2-yl]ethyl]-2-isopropyl-N,4-diphenyl-1H-pyrrole-3-carboxamide | C33H33FN2O4 | 详情 | 详情 | |
| (XIV) | 27911 | sodium (3R,5R)-7-[3-(anilinocarbonyl)-5-(4-fluorophenyl)-2-isopropyl-4-phenyl-1H-pyrrol-1-yl]-3,5-dihydroxyheptanoate | C33H34FN2NaO5 | 详情 | 详情 | |
| (XIV) | 45249 | sodium (3R,5R)-7-[3-(anilinocarbonyl)-5-(4-fluorophenyl)-2-isopropyl-4-phenyl-1H-pyrrol-1-yl]-3,5-dihydroxyheptanoate | C33H34FN2NaO5 | 详情 | 详情 |
合成路线3
该中间体在本合成路线中的序号：(XXXVIII)Alternatively, the hydrolysis of the intermediate dimethylacetal (XXVII) with TsOH in dioxane/water gives the aldehyde (XXXVII), which is condensed with tert-butyl acetate (XXXVIII) by means of LDA in THF, yielding the hydroxyester (XXXIX). The desilylation of (XXXIX) with HF/pyridine in THF affords the trihydroxy compound (XL), which is selectively resilylated with Tbdms-OTf and lutidine, providing the bis-silylated compound (XLI). The oxidation of the free OH group of (XLI) with DMP in dichloromethane gives the ketonic compound (XLII), which is treated with Tbdms-OTf and lutidine in dichloromethane to furnish the silyl ester (XLIII). The condensation of (XLIII) with the thiazole intermediate (IX) as before gives the adduct (XLIV), which is hydrolyzed by means of K2CO3 in methanol/water, yielding the hydroxyacid (XLV). The intramolecular lactonization of (XLV) by means of 2,4,6-trichlorobenzoyl chloride, TEA and DMAP in toluene affords the previously reported macrolactone (XXXV), which is desilylated with HF/pyridine to (XXXVI) and finally epoxidated with DMDO in dichloromethane.
| 【1】 Meng, D.; et al.; Total syntheses of epothilones A and B. J Am Chem Soc 1997, 119, 42, 10073. |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (IX) | 44493 | (1S,3Z)-4-iodo-1-[(E)-1-methyl-2-(2-methyl-1,3-thiazol-4-yl)ethenyl]-3-butenyl acetate | C13H16INO2S | 详情 | 详情 | |
| (XXVII) | 44549 | tert-butyl(dimethyl)silyl (1S,2S)-1-[(1R,2R)-4,4-dimethoxy-1,3,3-trimethyl-2-[(triphenylsilyl)oxy]butyl]-2-methyl-4-pentenyl ether; (3R,4R,5S)-3-(2,2-dimethoxy-1,1-dimethylethyl)-4,7,7,8,8-pentamethyl-5-[(1S)-1-methyl-3-butenyl]-1,1,1-triphenyl-2,6-dioxa-1,7-disilanonane | C39H58O4Si2 | 详情 | 详情 | |
| (XXXV) | 44446 | (4S,7R,8S,9S,16S)-4,8-bis[[tert-butyl(dimethyl)silyl]oxy]-5,5,7,9-tetramethyl-16-[(E)-1-methyl-2-(2-methyl-1,3-thiazol-4-yl)ethenyl]oxa-13-cyclohexadecene-2,6-dione | C38H67NO5SSi2 | 详情 | 详情 | |
| (XXXVI) | 44447 | (4S,7R,8S,9S,16S)-4,8-dihydroxy-5,5,7,9-tetramethyl-16-[(E)-1-methyl-2-(2-methyl-1,3-thiazol-4-yl)ethenyl]oxa-13-cyclohexadecene-2,6-dione | C26H39NO5S | 详情 | 详情 | |
| (XXXVII) | 44557 | (3R,4R,5S,6S)-5-[[tert-butyl(dimethyl)silyl]oxy]-2,2,4,6-tetramethyl-3-[(triphenylsilyl)oxy]-8-nonenal | C37H52O3Si2 | 详情 | 详情 | |
| (XXXVIII) | 15397 | tert-butyl acetate | 540-88-5 | C6H12O2 | 详情 | 详情 |
| (XXXIX) | 44558 | tert-butyl (3S,5R,6R,7S,8S)-7-[[tert-butyl(dimethyl)silyl]oxy]-3-hydroxy-4,4,6,8-tetramethyl-5-[(triphenylsilyl)oxy]-10-undecenoate | C43H64O5Si2 | 详情 | 详情 | |
| (XL) | 44559 | tert-butyl (3S,5R,6R,7S,8S)-3,5,7-trihydroxy-4,4,6,8-tetramethyl-10-undecenoate | C19H36O5 | 详情 | 详情 | |
| (XLI) | 44560 | tert-butyl (3S,5R,6S,7S,8S)-3,7-bis[[tert-butyl(dimethyl)silyl]oxy]-5-hydroxy-4,4,6,8-tetramethyl-10-undecenoate | C31H64O5Si2 | 详情 | 详情 | |
| (XLII) | 44561 | tert-butyl (3S,6R,7S,8S)-3,7-bis[[tert-butyl(dimethyl)silyl]oxy]-4,4,6,8-tetramethyl-5-oxo-10-undecenoate | C31H62O5Si2 | 详情 | 详情 | |
| (XLIII) | 44562 | tert-butyl(dimethyl)silyl (3S,6R,7S,8S)-3,7-bis[[tert-butyl(dimethyl)silyl]oxy]-4,4,6,8-tetramethyl-5-oxo-10-undecenoate | C33H68O5Si3 | 详情 | 详情 | |
| (XLIV) | 44563 | tert-butyl(dimethyl)silyl (3S,6R,7S,8S,12Z,15S,16E)-15-(acetoxy)-3,7-bis[[tert-butyl(dimethyl)silyl]oxy]-4,4,6,8,16-pentamethyl-17-(2-methyl-1,3-thiazol-4-yl)-5-oxo-12,16-heptadecadienoate | C46H85NO7SSi3 | 详情 | 详情 | |
| (XLV) | 44473 | (3S,6R,7S,8S,12Z,15S,16E)-3,7-bis[[tert-butyl(dimethyl)silyl]oxy]-15-hydroxy-4,4,6,8,16-pentamethyl-17-(2-methyl-1,3-thiazol-4-yl)-5-oxo-12,16-heptadecadienoic acid | C38H69NO6SSi2 | 详情 | 详情 |
合成路线4
该中间体在本合成路线中的序号：(V)Condensation of methyl 2-(chlorosulfonyl)benzoate (I) with 2-(trifluoromethyl)aniline (II) in the presence of DMAP and pyridine yielded sulfonamide (III), which was then cyclized in refluxing xylene to provide the saccharin derivative (IV). Further condensation with tert-butyl acetate (V) using potassium bis(trimethylsilyl)amide as the base afforded ketoester (VI). Then, bromination with NBS in CCl4 gave (VII), which was cyclized to the benzothiazine (VIII) with K2CO3 in DMF. Treatment with trifluoromethanesulfonic anhydride and pyridine in CH2Cl2 furnished the vinyl triflate (IX), and this was then coupled with boronic acid (X) in the presence of Pd(PPh3)4 and K2CO3 to produce (XI). Finally, the tert-butyl ester was cleaved with trifluoroacetic acid in CH2Cl2.
| 【1】 Lee, C.; et al.; Synthetic studies toward a series of endothelin receptor antagonists. 1,1-Dioxo-2,4-diphenyl-2H-1,2-benzothiazine. 216th ACS Natl Meet (Aug. 23-27, Boston) 1998, Abst MEDI 058. |
| 【2】 Berryman, K.A.; Bunker, A.M.; Doherty, A.M.; Edmunds, J.J. (Pfizer Inc.); Benzothiazine dioxides as endothelin antagonists. EP 0811001; JP 1999501013; WO 9626195 . |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 25811 | methyl 2-(chlorosulfonyl)benzoate | 26638-43-7 | C8H7ClO4S | 详情 | 详情 |
| (II) | 25812 | 2-(trifluoromethyl)phenylamine; 2-(trifluoromethyl)aniline | 88-17-5 | C7H6F3N | 详情 | 详情 |
| (III) | 25813 | methyl 2-[[2-(trifluoromethyl)anilino]sulfonyl]benzoate | C15H12F3NO4S | 详情 | 详情 | |
| (IV) | 25814 | 2-[2-(trifluoromethyl)phenyl]-1H-1,2-benzisothiazole-1,1,3(2H)-trione | C14H8F3NO3S | 详情 | 详情 | |
| (V) | 15397 | tert-butyl acetate | 540-88-5 | C6H12O2 | 详情 | 详情 |
| (VI) | 25815 | tert-butyl 3-oxo-3-(2-[[2-(trifluoromethyl)anilino]sulfonyl]phenyl)propanoate | C20H20F3NO5S | 详情 | 详情 | |
| (VII) | 25816 | tert-butyl 2-bromo-3-oxo-3-(2-[[2-(trifluoromethyl)anilino]sulfonyl]phenyl)propanoate | C20H19BrF3NO5S | 详情 | 详情 | |
| (VIII) | 25817 | tert-butyl 4-hydroxy-1,1-dioxo-2-[2-(trifluoromethyl)phenyl]-1,2-dihydro-1lambda(6),2-benzothiazine-3-carboxylate | C20H18F3NO5S | 详情 | 详情 | |
| (IX) | 25818 | tert-butyl 1,1-dioxo-2-[2-(trifluoromethyl)phenyl]-4-[[(trifluoromethyl)sulfonyl]oxy]-1,2-dihydro-1lambda(6),2-benzothiazine-3-carboxylate | C21H17F6NO7S2 | 详情 | 详情 | |
| (X) | 25819 | 7-ethyl-1,3-benzodioxol-5-ylboronic acid | C9H11BO4 | 详情 | 详情 | |
| (XI) | 25820 | tert-butyl 4-(7-ethyl-1,3-benzodioxol-5-yl)-1,1-dioxo-2-[2-(trifluoromethyl)phenyl]-1,2-dihydro-1lambda(6),2-benzothiazine-3-carboxylate | C29H26F3NO6S | 详情 | 详情 |
合成路线5
该中间体在本合成路线中的序号：(XXXVIII)Alternatively, the hydrolysis of the intermediate dimethylacetal (XXVII) with Ts-OH in dioxane/water gives the aldehyde (XXXVI), which is condensed with tert-butyl acetate (XXXVII) by means of LDA in THF, yielding the hydroxyester (XXXVIII). The desilylation of (XXXVIII) with HF/pyridine in THF affords the trihydroxy compound (XXXIX), which is selectively resilylated with Tbdms-OTf and lutidine, providing the bis-silylated compound (XL). The oxidation of the free OH group of (XL) with DMP in dichloromethane gives the ketonic compound (XLI), which is treated with Tbdms-OTf and lutidine in dichloromethane to furnish the silyl ester (XLII). The condensation of (XLII) with the thiazole intermediate (IX) as before gives the adduct (XLIII), which is hydrolyzed by means of K2CO3 in methanol/water, yielding the hydroxyacid (XLIV). The intramolecular lactonization of (XLIV) by means of 2,4,6-trichlorobenzoyl chloride, TEA and DMAP in toluene affords the already reported macrolactone (XXXV), which is finally desilylated with HF/pyridine to give the target epothilone C.
| 【1】 Meng, D.; et al.; Total syntheses of epothilones A and B. J Am Chem Soc 1997, 119, 42, 10073. |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (IX) | 44493 | (1S,3Z)-4-iodo-1-[(E)-1-methyl-2-(2-methyl-1,3-thiazol-4-yl)ethenyl]-3-butenyl acetate | C13H16INO2S | 详情 | 详情 | |
| (XXVII) | 44549 | tert-butyl(dimethyl)silyl (1S,2S)-1-[(1R,2R)-4,4-dimethoxy-1,3,3-trimethyl-2-[(triphenylsilyl)oxy]butyl]-2-methyl-4-pentenyl ether; (3R,4R,5S)-3-(2,2-dimethoxy-1,1-dimethylethyl)-4,7,7,8,8-pentamethyl-5-[(1S)-1-methyl-3-butenyl]-1,1,1-triphenyl-2,6-dioxa-1,7-disilanonane | C39H58O4Si2 | 详情 | 详情 | |
| (XXXV) | 44446 | (4S,7R,8S,9S,16S)-4,8-bis[[tert-butyl(dimethyl)silyl]oxy]-5,5,7,9-tetramethyl-16-[(E)-1-methyl-2-(2-methyl-1,3-thiazol-4-yl)ethenyl]oxa-13-cyclohexadecene-2,6-dione | C38H67NO5SSi2 | 详情 | 详情 | |
| (XXXVII) | 44557 | (3R,4R,5S,6S)-5-[[tert-butyl(dimethyl)silyl]oxy]-2,2,4,6-tetramethyl-3-[(triphenylsilyl)oxy]-8-nonenal | C37H52O3Si2 | 详情 | 详情 | |
| (XXXVIII) | 15397 | tert-butyl acetate | 540-88-5 | C6H12O2 | 详情 | 详情 |
| (XXXIX) | 44558 | tert-butyl (3S,5R,6R,7S,8S)-7-[[tert-butyl(dimethyl)silyl]oxy]-3-hydroxy-4,4,6,8-tetramethyl-5-[(triphenylsilyl)oxy]-10-undecenoate | C43H64O5Si2 | 详情 | 详情 | |
| (XL) | 44559 | tert-butyl (3S,5R,6R,7S,8S)-3,5,7-trihydroxy-4,4,6,8-tetramethyl-10-undecenoate | C19H36O5 | 详情 | 详情 | |
| (XLI) | 44560 | tert-butyl (3S,5R,6S,7S,8S)-3,7-bis[[tert-butyl(dimethyl)silyl]oxy]-5-hydroxy-4,4,6,8-tetramethyl-10-undecenoate | C31H64O5Si2 | 详情 | 详情 | |
| (XLII) | 44561 | tert-butyl (3S,6R,7S,8S)-3,7-bis[[tert-butyl(dimethyl)silyl]oxy]-4,4,6,8-tetramethyl-5-oxo-10-undecenoate | C31H62O5Si2 | 详情 | 详情 | |
| (XLIII) | 44562 | tert-butyl(dimethyl)silyl (3S,6R,7S,8S)-3,7-bis[[tert-butyl(dimethyl)silyl]oxy]-4,4,6,8-tetramethyl-5-oxo-10-undecenoate | C33H68O5Si3 | 详情 | 详情 | |
| (XLIV) | 44563 | tert-butyl(dimethyl)silyl (3S,6R,7S,8S,12Z,15S,16E)-15-(acetoxy)-3,7-bis[[tert-butyl(dimethyl)silyl]oxy]-4,4,6,8,16-pentamethyl-17-(2-methyl-1,3-thiazol-4-yl)-5-oxo-12,16-heptadecadienoate | C46H85NO7SSi3 | 详情 | 详情 | |
| (XLV) | 44473 | (3S,6R,7S,8S,12Z,15S,16E)-3,7-bis[[tert-butyl(dimethyl)silyl]oxy]-15-hydroxy-4,4,6,8,16-pentamethyl-17-(2-methyl-1,3-thiazol-4-yl)-5-oxo-12,16-heptadecadienoic acid | C38H69NO6SSi2 | 详情 | 详情 |