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【结 构 式】 
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【分子编号】14635 【品名】3-[2-[(2',4'-difluoro[1,1'-biphenyl]-4-yl)oxy]ethyl]-4(3H)-quinazolinone 【CA登记号】 |
【 分 子 式 】C22H16F2N2O2 【 分 子 量 】378.3781264 【元素组成】C 69.84% H 4.26% F 10.04% N 7.4% O 8.46% |
与该中间体有关的原料药合成路线共 1 条
合成路线1
该中间体在本合成路线中的序号：(V)Flubichin (V) is prepared by a reaction of 4(3H)-quinazolinone (IV) with 2',4'-difluoro-4-(2-chloroethoxy)biphenyl (III). Compound (III) can be prepared by reaction of 2',4'-difluoro-4-hydroxybiphenyl (I) with 2-chloroethyl p-toluene sulfonate (II). Methanesulfonate of flubichin is obtained by reaction of flubichin base (V) with methanesulfonic acid in chloroform.
| 【1】 Fisnerová, L.; Brunová, B.; Maturová, E.; Grimová, J. (SPOFA - United Pharmaceutical Works); Ether deriv. of 4-[3H]-quinazoline, a process for the preparation thereof, and pharmaceutical compsns. AU 8942880; EP 0367944; JP 1990172977 . |
| 【2】 Rejholec, V.; Flubichin Methanesulfonate. Drugs Fut 1991, 16, 8, 715. |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 14631 | 2',4'-difluoro[1,1'-biphenyl]-4-ol | C12H8F2O | 详情 | 详情 | |
| (II) | 14632 | 2-chloroethyl 4-methylbenzenesulfonate; 2-Chloroethyl-p-toluenesulfonate | 80-41-1 | C9H11ClO3S | 详情 | 详情 |
| (III) | 14633 | 2-chloroethyl 2',4'-difluoro[1,1'-biphenyl]-4-yl ether; 4-(2-chloroethoxy)-2',4'-difluoro-1,1'-biphenyl | C14H11ClF2O | 详情 | 详情 | |
| (IV) | 14634 | 4(3H)-quinazolinone | C8H6N2O | 详情 | 详情 | |
| (V) | 14635 | 3-[2-[(2',4'-difluoro[1,1'-biphenyl]-4-yl)oxy]ethyl]-4(3H)-quinazolinone | C22H16F2N2O2 | 详情 | 详情 |
Extended Information