2-chloroethyl 2',4'-difluoro[1,1'-biphenyl]-4-yl ether; 4-(2-chloroethoxy)-2',4'-difluoro-1,1'-biphenyl -Drug Synthesis Database

【结构式】

【分子编号】14633

【品名】2-chloroethyl 2',4'-difluoro[1,1'-biphenyl]-4-yl ether; 4-(2-chloroethoxy)-2',4'-difluoro-1,1'-biphenyl

【CA登记号】

【分子式】C₁₄H₁₁ClF₂O

【分子量】268.6902464

【元素组成】C 62.58% H 4.13% Cl 13.19% F 14.14% O 5.95%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号：(III)

Flubichin (V) is prepared by a reaction of 4(3H)-quinazolinone (IV) with 2',4'-difluoro-4-(2-chloroethoxy)biphenyl (III). Compound (III) can be prepared by reaction of 2',4'-difluoro-4-hydroxybiphenyl (I) with 2-chloroethyl p-toluene sulfonate (II). Methanesulfonate of flubichin is obtained by reaction of flubichin base (V) with methanesulfonic acid in chloroform.

参考文献中间体

合成目标

【1】 Fisnerová, L.; Brunová, B.; Maturová, E.; Grimová, J. (SPOFA - United Pharmaceutical Works); Ether deriv. of 4-[3H]-quinazoline, a process for the preparation thereof, and pharmaceutical compsns. AU 8942880; EP 0367944; JP 1990172977 .
【2】 Rejholec, V.; Flubichin Methanesulfonate. Drugs Fut 1991, 16, 8, 715.

中间体序号	中间体编号	品名	CAS号	分子式	供应商	用于合成
(I)	14631	2',4'-difluoro[1,1'-biphenyl]-4-ol		C₁₂H₈F₂O	详情	详情
(II)	14632	2-chloroethyl 4-methylbenzenesulfonate; 2-Chloroethyl-p-toluenesulfonate	80-41-1	C₉H₁₁ClO₃S	详情	详情
(III)	14633	2-chloroethyl 2',4'-difluoro[1,1'-biphenyl]-4-yl ether; 4-(2-chloroethoxy)-2',4'-difluoro-1,1'-biphenyl		C₁₄H₁₁ClF₂O	详情	详情
(IV)	14634	4(3H)-quinazolinone		C₈H₆N₂O	详情	详情
(V)	14635	3-[2-[(2',4'-difluoro[1,1'-biphenyl]-4-yl)oxy]ethyl]-4(3H)-quinazolinone		C₂₂H₁₆F₂N₂O₂	详情	详情

Extended Information