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【结 构 式】 
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【分子编号】13664 【品名】1,1,1-Trichloro-2-[(chlorocarbonyl)oxy]ethane; 2,2,2-Trichloroethyl chloroformate 【CA登记号】17341-93-4 |
【 分 子 式 】C3H2Cl4O2 【 分 子 量 】211.85848 【元素组成】C 17.01% H 0.95% Cl 66.94% O 15.1% |
合成路线1
该中间体在本合成路线中的序号：(C)The cyclization of (XXII) by means of CsF in DMSO gives the tris macrocyclic compound (XXIII), which simultaneously eliminates the TEOC protecting group yielding (XXIV) with a free amino group. The silylation of the OH group of (XXIV) with CF3CO-N(Me)-TBDMS (B) affords the silyl ether (XXV), which is protected at its amino group with Troc-Cl (C) providing the fully protected compound (XXVI).
| 【1】 Boger, D.L.; et al.; First and second generation total synthesis of the teicoplanin aglycon. J Am Chem Soc 2001, 123, 9, 1862. |
| 【2】 Boger, D.L.; et al.; Total synthesis of the teicoplanin aglycon. J Am Chem Soc 2000, 122, 30, 7416. |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (B) | 40575 | N-[tert-butyl(dimethyl)silyl]-2,2,2-trifluoro-N-methylacetamide | 77377-52-7 | C9H18F3NOSi | 详情 | 详情 |
| (XXII) | 40572 | C83H90ClFN8O24 | 详情 | 详情 | ||
| (XXIII) | 40573 | C83H89ClN8O24 | 详情 | 详情 | ||
| (XXIV) | 40574 | C80H85ClN8O23 | 详情 | 详情 | ||
| (XXV) | 40576 | C86H99ClN8O23Si | 详情 | 详情 | ||
| (XXVI) | 40577 | C89H100Cl4N8O25Si | 详情 | 详情 | ||
| (C) | 13664 | 1,1,1-Trichloro-2-[(chlorocarbonyl)oxy]ethane; 2,2,2-Trichloroethyl chloroformate | 17341-93-4 | C3H2Cl4O2 | 详情 | 详情 |
合成路线2
该中间体在本合成路线中的序号：(II)The acylation of 5-(methylaminomethyl)furan-2-methanol (I) with 2,2,2-trichloroethyl chloroformate (II) and pyridine in dichloromethane gives the corresponding N-acyl derivative (III), which is condensed with 2-mercaptoethylamine (IV) by means of sodium methoxide in methanol to yield the thioether (V). The condensation of (V) with diphenyl methanesulfonimidocarbonate (VI) and 2-hydroxy-2-(4-hydroxyphenyl)ethylamine (VII) by means of potassium acetate and triethylamine in acetonitrile - propanol affords the protected final product (VIII), which is finally deprotected by treatment with activated Zn and potassium dihydrogen phosphate.
| 【1】 Hirai, S.; Hirano, H.; Arai, H.; Shibata, H.; Kusayanagi, Y.; Hashiba, K. (Toyama Chemical Co., Ltd.); Amine deriv. and its salts and antiulcer agent containing the same. CH 675244; DE 3828869; US 4871765 . |
| 【2】 Castaner, J.; Prous, J.; Mealy, N.; T-593. Drugs Fut 1993, 18, 9, 809. |
| 【3】 Shibata, H.; Hirai, N.; Kusayanagi, K.; Arai, H.; Hirano, H.; Synthesis of beta-hydroxyphenethyl-based compounds and their physico-chemical properties and structural features. 113th Annu Meet Pharmaceut Soc Jpn (March 29-31, Osaka) 1993, Abst 29PB 10-28. |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 13663 | [5-[(Methylamino)methyl]-2-furyl]methanol | C7H11NO2 | 详情 | 详情 | |
| (II) | 13664 | 1,1,1-Trichloro-2-[(chlorocarbonyl)oxy]ethane; 2,2,2-Trichloroethyl chloroformate | 17341-93-4 | C3H2Cl4O2 | 详情 | 详情 |
| (III) | 13665 | 2,2,2-trichloroethyl [5-(hydroxymethyl)-2-furyl]methyl(methyl)carbamate | C10H12Cl3NO4 | 详情 | 详情 | |
| (IV) | 13186 | 2-Aminoethanethiol; 2-Amino-1-ethanethiol; 2-Aminoethylhydrosulfide; Cysteamine | 60-23-1 | C2H7NS | 详情 | 详情 |
| (V) | 13667 | 2,2,2-trichloroethyl (5-[[(2-aminoethyl)sulfanyl]methyl]-2-furyl)methyl(methyl)carbamate | C12H17Cl3N2O3S | 详情 | 详情 | |
| (VI) | 13668 | N-(Diphenoxymethylene)methanesulfonamide | C14H13NO4S | 详情 | 详情 | |
| (VII) | 13669 | 4-(2-Amino-1-hydroxyethyl)phenol | 104-14-3 | C8H11NO2 | 详情 | 详情 |
| (VIII) | 13670 | 2,2,2-trichloroethyl [5-((E)-6-[[2-hydroxy-2-(4-hydroxyphenyl)ethyl]amino]-8,8-dioxo-2,8lambda(6)-dithia-5,7-diaza-6-nonen-1-yl)-2-furyl]methyl(methyl)carbamate | C22H29Cl3N4O7S2 | 详情 | 详情 |
合成路线3
该中间体在本合成路线中的序号：The isomerization of arecoline (I) with LDA gives 1-methyl-1,2,3,6-tetrahydropyridine-3-carboxylic acid methyl ester (II), which is reduced with LiAlH4 in THF yielding the carbinol (III). The protection of (III) with trichloroethyl chloroformate (Troc-Cl) and DIEA in toluene affords the demethylated compound (IV), which is treated with K2CO3 in methanol providing 3-(hydroxymethyl)-1,2,3,6-tetrahydropyridine-1-carboxylic acid 2,2,2-trichloroethyl ester (V). The silylation of (V) with TBDPSCl and imidazole in DMF gives the silyl ether (VI), which is epoxidized with MCPBA in dichloromethane yielding the epoxide (VII). Epoxide (VII) opening by means of HClO4 in refluxing water affords a diastereomeric mixture of racemates (VIII) and (IX) that could not be separated. The cleavage of the carbamate group of (VIII) and (IX) by means of HCl in water gives a new mixture that could be separated by flash chromatography to furnish the target compound as a racemate. Alternatively, intermediate (IV) is epoxidized with MCPBA in dichloromethane yielding the epoxide (X), which is treated as before.
| 【1】 Bols, M.; Hansen, S.U.; Synthesis of (±)-isofagomine and its stereoisomers from arecoline. J Chem Soc - Perkins Trans I 2000, 6, 911. |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| 13664 | 1,1,1-Trichloro-2-[(chlorocarbonyl)oxy]ethane; 2,2,2-Trichloroethyl chloroformate | 17341-93-4 | C3H2Cl4O2 | 详情 | 详情 | |
| (I) | 38648 | methyl 1-methyl-1,2,5,6-tetrahydro-3-pyridinecarboxylate | C8H13NO2 | 详情 | 详情 | |
| (II) | 38649 | methyl 1-methyl-1,2,3,6-tetrahydro-3-pyridinecarboxylate | C8H13NO2 | 详情 | 详情 | |
| (III) | 38650 | (1-methyl-1,2,3,6-tetrahydro-3-pyridinyl)methanol | C7H13NO | 详情 | 详情 | |
| (IV) | 38651 | 2,2,2-trichloroethyl 3-([[(2,2,2-trichloroethoxy)carbonyl]oxy]methyl)-3,6-dihydro-1(2H)-pyridinecarboxylate | C12H13Cl6NO5 | 详情 | 详情 | |
| (V) | 38652 | 2,2,2-trichloroethyl 3-(hydroxymethyl)-3,6-dihydro-1(2H)-pyridinecarboxylate | C9H12Cl3NO3 | 详情 | 详情 | |
| (VI) | 38653 | 2,2,2-trichloroethyl 3-([[tert-butyl(diphenyl)silyl]oxy]methyl)-3,6-dihydro-1(2H)-pyridinecarboxylate | C25H30Cl3NO3Si | 详情 | 详情 | |
| (VII) | 38654 | 2,2,2-trichloroethyl 5-([[tert-butyl(diphenyl)silyl]oxy]methyl)-7-oxa-3-azabicyclo[4.1.0]heptane-3-carboxylate | C25H30Cl3NO4Si | 详情 | 详情 | |
| (VIII) | 38655 | 2,2,2-trichloroethyl (3R,4R,5R)-3,4-dihydroxy-5-(hydroxymethyl)-1-piperidinecarboxylate | C9H14Cl3NO5 | 详情 | 详情 | |
| (IX) | 38656 | 2,2,2-trichloroethyl (3S,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)-1-piperidinecarboxylate | C9H14Cl3NO5 | 详情 | 详情 | |
| (X) | 38657 | 2,2,2-trichloroethyl 5-([[(2,2,2-trichloroethoxy)carbonyl]oxy]methyl)-7-oxa-3-azabicyclo[4.1.0]heptane-3-carboxylate | C12H13Cl6NO6 | 详情 | 详情 |
合成路线4
该中间体在本合成路线中的序号：Treatment of diketoester (I) with trimethylsilyl diazomethane and diisopropyl ethylamine produced enol ether (II). This was condensed with (S)-2-methyl-4-pentenal (III) in the presence of LDA at -120 C to afford the aldol condensation product (IV) as the major isomer. Protection of the 7-hydroxyl group of (IV) with trichloroethoxycarbonyl chloride gave carbonate (V). Enol ether of (V) was then hydrolyzed with p-TsOH in acetone to provide diketoester (VI). Hydroboration of the terminal olefin of (VI) with 9-borabicyclo[3.3.1]nonane gave organoborane (VII). Then, Suzuki coupling of (VII) with vinyl iodide (VIII), followed by acid hydrolysis of the silyl protecting group, provided the thiazolyl heptadecadienoate (IX). Asymmetric hydrogenation of 3-keto group of (IX) in the presence of the modified Noyori's catalyst [RuCl2(R)-BINAP)]2[Et3N] furnished the desired 3-(S) alcohol (X).
| 【1】 Harris, C.R.; et al.; New chemical synthesis of the promising cancer chemotherapeutic agent 12,13-desoxyepothilone B: Discovery of a surprising long-range effect on the diastereoselectivity of an aldol condensation. J Am Chem Soc 1999, 121, 30, 7050. |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| 13664 | 1,1,1-Trichloro-2-[(chlorocarbonyl)oxy]ethane; 2,2,2-Trichloroethyl chloroformate | 17341-93-4 | C3H2Cl4O2 | 详情 | 详情 | |
| (I) | 26239 | tert-butyl 4,4-dimethyl-3,5-dioxoheptanoate | C13H22O4 | 详情 | 详情 | |
| (II) | 26240 | tert-butyl (Z)-3-methoxy-4,4-dimethyl-5-oxo-2-heptenoate | C14H24O4 | 详情 | 详情 | |
| (III) | 26241 | (2S)-2-methyl-4-pentenal | C6H10O | 详情 | 详情 | |
| (IV) | 26242 | tert-butyl (2Z,6R,7S,8S)-7-hydroxy-3-methoxy-4,4,6,8-tetramethyl-5-oxo-2,10-undecadienoate | C20H34O5 | 详情 | 详情 | |
| (V) | 26243 | tert-butyl (2Z,6R,7S,8S)-3-methoxy-4,4,6,8-tetramethyl-5-oxo-7-[[(2,2,2-trichloroethoxy)carbonyl]oxy]-2,10-undecadienoate | C23H35Cl3O7 | 详情 | 详情 | |
| (VI) | 26244 | tert-butyl (6R,7S,8S)-4,4,6,8-tetramethyl-3,5-dioxo-7-[[(2,2,2-trichloroethoxy)carbonyl]oxy]-10-undecenoate | C22H33Cl3O7 | 详情 | 详情 | |
| (VII) | 26245 | tert-butyl (6R,7S,8S)-11-(9-borabicyclo[3.3.1]non-9-yl)-4,4,6,8-tetramethyl-3,5-dioxo-7-[[(2,2,2-trichloroethoxy)carbonyl]oxy]undecanoate | C30H48BCl3O7 | 详情 | 详情 | |
| (VIII) | 26246 | tert-butyl(dimethyl)silyl (1S,3Z)-4-iodo-1-[(E)-1-methyl-2-(2-methyl-1,3-thiazol-4-yl)ethenyl]-3-pentenyl ether; 4-((1E,3S,5Z)-3-[[tert-butyl(dimethyl)silyl]oxy]-6-iodo-2-methyl-1,5-heptadienyl)-2-methyl-1,3-thiazole | C18H30INOSSi | 详情 | 详情 | |
| (IX) | 26247 | tert-butyl (6R,7S,8S,12Z,15S,16E)-15-hydroxy-4,4,6,8,12,16-hexamethyl-17-(2-methyl-1,3-thiazol-4-yl)-3,5-dioxo-7-[[(2,2,2-trichloroethoxy)carbonyl]oxy]-12,16-heptadecadienoate | C34H50Cl3NO8S | 详情 | 详情 | |
| (X) | 26248 | tert-butyl (3S,6R,7S,8S,12Z,15S,16E)-3,15-dihydroxy-4,4,6,8,12,16-hexamethyl-17-(2-methyl-1,3-thiazol-4-yl)-5-oxo-7-[[(2,2,2-trichloroethoxy)carbonyl]oxy]-12,16-heptadecadienoate | C34H52Cl3NO8S | 详情 | 详情 |
合成路线5
该中间体在本合成路线中的序号：The reaction of succinic anhydride (I) with the lithium salt of the chiral oxazolidinone (II) in THF gives 3-(hydroxysucccinyl)-4(S)-isopropyloxazolidin-2-one (III), which is treated successively with oxalyl chloride, CH2N2 and HBr to yield the bromomethyl derivative (IV). The cyclization of (IV) with thiourea in refluxing isopropanol affords the 2-aminothiazol derivative (V), which is protected with 2,2,2-trichloroethyl chloroformate by means of DIEA and DMAP in dichloromethane giving the carbamate (VI). The reaction of (VI) with tert-butyl 2-bromoacetate (VII) by means of sodium hexamethyldisilazane (NaHMDS) in THF yields the chiral butyrate (VIII), which is hydrolyzed with TFA in dichloromethane to the chiral butyric acid (IX). The condensation of (IX) with the intermediate amine (X) by means of BOP-PF6 and DIEA in DMF affords the corresponding amide (XI), which is treated with magnesium methoxide in methanol to eliminate the oxazolidinone group (the chiral inductor) providing the methyl ester (XII). The hydrolysis of (XII) with NaOH, followed by condensation with amine (XIII) (J Org Chem 1988, 53: 6109; J Med Chem 1993, 36: 449) gives the protected intermediate (XIV), which is finally deprotected by reaction with Zn/HCl in aqueous dioxane.
| 【1】 Simoneau, B.; Lavallee, P.; Anderson, P.C.; et al.; Discovery of non-peptidic P2-P3 butanediamide renin inhibitors with high oral efficacy. Bioorg Med Chem 1999, 7, 3, 489. |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| 10180 | Thiourea | 62-56-6 | CH4N2S | 详情 | 详情 | |
| 13664 | 1,1,1-Trichloro-2-[(chlorocarbonyl)oxy]ethane; 2,2,2-Trichloroethyl chloroformate | 17341-93-4 | C3H2Cl4O2 | 详情 | 详情 | |
| (I) | 11291 | Dihydro-2,5-furandione; Succinic anhydride | 108-30-5 | C4H4O3 | 详情 | 详情 |
| (II) | 29533 | [(4S)-4-isopropyl-2-oxo-1,3-oxazolidin-3-yl]lithium | C6H10LiNO2 | 详情 | 详情 | |
| (III) | 29534 | 4-[(4S)-4-isopropyl-2-oxo-1,3-oxazolidin-3-yl]-4-oxobutyric acid | C10H15NO5 | 详情 | 详情 | |
| (IV) | 29535 | 5-bromo-1-[(4S)-4-isopropyl-2-oxo-1,3-oxazolidin-3-yl]-1,4-pentanedione | C11H16BrNO4 | 详情 | 详情 | |
| (V) | 29536 | (4S)-3-[3-(2-amino-1,3-thiazol-4-yl)propanoyl]-4-isopropyl-1,3-oxazolidin-2-one | C12H17N3O3S | 详情 | 详情 | |
| (VI) | 29537 | 2,2,2-trichloroethyl 4-[3-[(4S)-4-isopropyl-2-oxo-1,3-oxazolidin-3-yl]-3-oxopropyl]-1,3-thiazol-2-ylcarbamate | C15H18Cl3N3O5S | 详情 | 详情 | |
| (VII) | 17430 | 2-Bromoacetic acid tert-butyl ester; tert-butyl 2-bromoacetate; tert-Butyl bromoacetate | 5292-43-3 | C6H11BrO2 | 详情 | 详情 |
| (VIII) | 29538 | tert-butyl (3R)-4-[(4S)-4-isopropyl-2-oxo-1,3-oxazolidin-3-yl]-4-oxo-3-[(2-[[(2,2,2-trichloroethoxy)carbonyl]amino]-1,3-thiazol-4-yl)methyl]butanoate | C21H28Cl3N3O7S | 详情 | 详情 | |
| (IX) | 29539 | (3R)-4-[(4S)-4-isopropyl-2-oxo-1,3-oxazolidin-3-yl]-4-oxo-3-[(2-[[(2,2,2-trichloroethoxy)carbonyl]amino]-1,3-thiazol-4-yl)methyl]butyric acid | C17H20Cl3N3O7S | 详情 | 详情 | |
| (X) | 29540 | 2-[(cyclohexylmethyl)amino]-N-methyl-N-[2-(2-pyridinyl)ethyl]acetamide | C17H27N3O | 详情 | 详情 | |
| (XI) | 29541 | 2,2,2-trichloroethyl 4-((2R)-4-[(cyclohexylmethyl)(2-[methyl[2-(2-pyridinyl)ethyl]amino]-2-oxoethyl)amino]-2-[[(4S)-4-isopropyl-2-oxo-1,3-oxazolidin-3-yl]carbonyl]-4-oxobutyl)-1,3-thiazol-2-ylcarbamate | C34H45Cl3N6O7S | 详情 | 详情 | |
| (XII) | 29542 | methyl (2R)-4-[(cyclohexylmethyl)(2-[methyl[2-(2-pyridinyl)ethyl]amino]-2-oxoethyl)amino]-4-oxo-2-[(2-[[(2,2,2-trichloroethoxy)carbonyl]amino]-1,3-thiazol-4-yl)methyl]butanoate | C29H38Cl3N5O6S | 详情 | 详情 | |
| (XIII) | 29543 | (2S,3R,4S)-2-amino-1-cyclohexyl-6-methyl-3,4-heptanediol | C14H29NO2 | 详情 | 详情 | |
| (XIV) | 29544 | 2,2,2-trichloroethyl 4-[(2R)-2-([[(1S,2R,3S)-1-(cyclohexylmethyl)-2,3-dihydroxy-5-methylhexyl]amino]carbonyl)-4-[(cyclohexylmethyl)(2-[methyl[2-(2-pyridinyl)ethyl]amino]-2-oxoethyl)amino]-4-oxobutyl]-1,3-thiazol-2-ylcarbamate | C42H63Cl3N6O7S | 详情 | 详情 |
合成路线6
该中间体在本合成路线中的序号：(IV)The reaction of anhydroecgonine methyl ester (I) with 4-methylphenylmagnesium bromide (II) in ethyl ether gives 3beta-(4-methylphenyl)tropane-2beta-carboxylic acid methyl ester (III), which is demethylated by reaction with 2,2,2-trichloroethyl chloroformate (IV) yielding the carbamate (V), followed by reduction with Zn/AcOH to afford the nortropane derivative (VI). The alkylation of (VI) with the tributylstannane (VII), TEA and iodine in ethanol provides the adduct (VIII), which is finally brominated with NBS in THF.
| 【1】 Clarke, R.L.; et al.; Compounds affecting the central nervous system. 4. 3beta-Phenyltropane-2-carboxylic esters and analogs. J Med Chem 1973, 16, 1, 1260-67. |
| 【2】 Carroll, F.I.; Gao, Y.; Rahman, M.A.; Abraham, P.; Parham, K.; Lewin, A.H.; Boja, J.W.; Kuhar, M.J.; Synthesis, ligand binding, QSAR, and CoMFA study of 3beta-(p-substitutedphenyl)tropane-2beta-carboxylic acid methyl esters. J Med Chem 1991, 34, 9, 2719. |
| 【3】 Helfenbein, J.; et al.; Synthesis of (E)-N-(3-bromoprop-2-enyl)-2 beta-carbomethoxy-3 beta-(4 '-tolyl) nortropane (PE2Br) and radiolabelling of [Br-76]PE2Br: A potential ligand for exploration of the dopamine transporter by PET. J Label Compd Radiopharm 1999, 42, 6, 581. |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 40516 | methyl (1R,5R)-8-methyl-8-azabicyclo[3.2.1]oct-2-ene-2-carboxylate | C10H15NO2 | 详情 | 详情 | |
| (II) | 35657 | bromo(4-methylphenyl)magnesium | 4294-57-9 | C7H7BrMg | 详情 | 详情 |
| (III) | 40517 | methyl (1R,2S,3S,5R)-8-methyl-3-(4-methylphenyl)-8-azabicyclo[3.2.1]octane-2-carboxylate | C17H23NO2 | 详情 | 详情 | |
| (IV) | 13664 | 1,1,1-Trichloro-2-[(chlorocarbonyl)oxy]ethane; 2,2,2-Trichloroethyl chloroformate | 17341-93-4 | C3H2Cl4O2 | 详情 | 详情 |
| (V) | 40518 | 2-methyl 8-(2,2,2-trichloroethyl) (1R,2S,3S,5R)-3-(4-methylphenyl)-8-azabicyclo[3.2.1]octane-2,8-dicarboxylate | C19H22Cl3NO4 | 详情 | 详情 | |
| (VI) | 40519 | methyl (1R,2S,3S,5R)-3-(4-methylphenyl)-8-azabicyclo[3.2.1]octane-2-carboxylate | C16H21NO2 | 详情 | 详情 | |
| (VII) | 40520 | tributyl[(E)-3-chloro-2-propenyl]stannane | C15H31ClSn | 详情 | 详情 | |
| (VIII) | 40521 | methyl (1R,2S,3S,5R)-3-(4-methylphenyl)-8-[(E)-3-(tributylstannyl)-1-propenyl]-8-azabicyclo[3.2.1]octane-2-carboxylate | C31H51NO2Sn | 详情 | 详情 |
合成路线7
该中间体在本合成路线中的序号：(A)Acylation of amino alcohol (I) with (R)-3-(n-tetradecanoyloxy)tetradecanoic acid (II) employing 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide methiodide (EDC.MeI) provided amide (III). After hydroxyl group protection with 2,2,2-trichloroethyl chloroformate (A), the resulting acetonide (IV) was hydrolyzed with aqueous AcOH to give (V).
| 【1】 Sowell, C.G.; Johnson, D.A.; Keegan, D.S.; et al.; 3-O-Desacyl monophosphoryl lipid A derivatives: Synthesis and immunostimulant activities. J Med Chem 1999, 42, 22, 4640. |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (A) | 13664 | 1,1,1-Trichloro-2-[(chlorocarbonyl)oxy]ethane; 2,2,2-Trichloroethyl chloroformate | 17341-93-4 | C3H2Cl4O2 | 详情 | 详情 |
| (I) | 16046 | (4aR,6R,7R,8R,8aS)-7-amino-6-(benzyloxy)-2,2-dimethylhexahydropyrano[3,2-d][1,3]dioxin-8-ol | C16H23NO5 | 详情 | 详情 | |
| (II) | 40612 | (3R)-3-(tetradecanoyloxy)tetradecanoic acid | C28H54O4 | 详情 | 详情 | |
| (III) | 40613 | (1R)-1-(2-[[(4aR,6R,7R,8R,8aS)-6-(benzyloxy)-8-hydroxy-2,2-dimethylhexahydropyrano[3,2-d][1,3]dioxin-7-yl]amino]-2-oxoethyl)dodecyl myristate | C44H75NO8 | 详情 | 详情 | |
| (IV) | 40614 | (1R)-1-[2-[((4aR,6R,7R,8R,8aR)-6-(benzyloxy)-2,2-dimethyl-8-[[(2,2,2-trichloroethoxy)carbonyl]oxy]hexahydropyrano[3,2-d][1,3]dioxin-7-yl)amino]-2-oxoethyl]dodecyl myristate | C47H76Cl3NO10 | 详情 | 详情 | |
| (V) | 40615 | (1R)-1-[2-[((2R,3R,4R,5R,6R)-2-(benzyloxy)-5-hydroxy-6-(hydroxymethyl)-4-[[(2,2,2-trichloroethoxy)carbonyl]oxy]tetrahydro-2H-pyran-3-yl)amino]-2-oxoethyl]dodecyl myristate | C44H72Cl3NO10 | 详情 | 详情 |
合成路线8
该中间体在本合成路线中的序号：(B)N-Protection of amino alcohol (VI) under Schotten-Baumann conditions with 2,2,2-trichloroethyl chloroformate (B) aforded carbamate (VII). Subsequent esterification of (VII) with acid (II) provided (VIII), which was followed by acetonide hydrolysis to give diol (IX). Selective protection of the primary hydroxyl of (IX) with 1,1-dimethyl-2,2,2-trichloroethyl chloroformate (C) furnished carbonate (X). Further phosphorylation of the free secondary hydroxyl of (X) with diphenylphosphoryl chloride (D) produced phosphate ester (XI). Conversion of the trimethylsily-ethyl glycoside (XI) into the desired glycosyl chloride (XII) was then accomplished by treatment with alpha,alpha-dichloromethyl methyl ether and ZnCl2.
| 【1】 Sowell, C.G.; Johnson, D.A.; Keegan, D.S.; et al.; 3-O-Desacyl monophosphoryl lipid A derivatives: Synthesis and immunostimulant activities. J Med Chem 1999, 42, 22, 4640. |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (B) | 13664 | 1,1,1-Trichloro-2-[(chlorocarbonyl)oxy]ethane; 2,2,2-Trichloroethyl chloroformate | 17341-93-4 | C3H2Cl4O2 | 详情 | 详情 |
| (D) | 16074 | Diphenyl phosphoryl chloride; 1,1'-Diphenylphosphoryl chloride; Chlorodiphenyl Phosphate; Diphenyl chlorophosphate; Diphenylchlorophosphate | 2524-64-3 | C12H10ClO3P | 详情 | 详情 |
| (II) | 40612 | (3R)-3-(tetradecanoyloxy)tetradecanoic acid | C28H54O4 | 详情 | 详情 | |
| (VI) | 39769 | (4aR,6R,7R,8R,8aS)-7-amino-2,2-dimethyl-6-[2-(trimethylsilyl)ethoxy]hexahydropyrano[3,2-d][1,3]dioxin-8-ol | C14H29NO5Si | 详情 | 详情 | |
| (VII) | 39770 | 2,2,2-trichloroethyl (4aR,6R,7R,8R,8aS)-8-hydroxy-2,2-dimethyl-6-[2-(trimethylsilyl)ethoxy]hexahydropyrano[3,2-d][1,3]dioxin-7-ylcarbamate | C17H30Cl3NO7Si | 详情 | 详情 | |
| (VIII) | 39772 | (4aR,6R,7R,8R,8aR)-2,2-dimethyl-7-[[(2,2,2-trichloroethoxy)carbonyl]amino]-6-[2-(trimethylsilyl)ethoxy]hexahydropyrano[3,2-d][1,3]dioxin-8-yl (3R)-3-(tetradecanoyloxy)tetradecanoate | C45H82Cl3NO10Si | 详情 | 详情 | |
| (IX) | 39773 | (2R,3R,4R,5R,6R)-3-hydroxy-2-(hydroxymethyl)-5-[[(2,2,2-trichloroethoxy)carbonyl]amino]-6-[2-(trimethylsilyl)ethoxy]tetrahydro-2H-pyran-4-yl (3R)-3-(tetradecanoyloxy)tetradecanoate | C42H78Cl3NO10Si | 详情 | 详情 | |
| (X) | 39774 | (2R,3R,4R,5R,6R)-3-hydroxy-2-([[(2,2,2-trichloro-1,1-dimethylethoxy)carbonyl]oxy]methyl)-5-[[(2,2,2-trichloroethoxy)carbonyl]amino]-6-[2-(trimethylsilyl)ethoxy]tetrahydro-2H-pyran-4-yl (3R)-3-(tetradecanoyloxy)tetradecanoate | C47H83Cl6NO12Si | 详情 | 详情 | |
| (XI) | 39775 | (2R,3R,4R,5R,6R)-3-[(diphenoxyphosphoryl)oxy]-2-([[(2,2,2-trichloro-1,1-dimethylethoxy)carbonyl]oxy]methyl)-5-[[(2,2,2-trichloroethoxy)carbonyl]amino]-6-[2-(trimethylsilyl)ethoxy]tetrahydro-2H-pyran-4-yl (3R)-3-(tetradecanoyloxy)tetradecanoate | C59H92Cl6NO15PSi | 详情 | 详情 | |
| (XII) | 40616 | (2R,3R,4R,5S,6R)-2-chloro-5-[(diphenoxyphosphoryl)oxy]-6-([[(2,2,2-trichloro-1,1-dimethylethoxy)carbonyl]oxy]methyl)-3-[[(2,2,2-trichloroethoxy)carbonyl]amino]tetrahydro-2H-pyran-4-yl (3R)-3-(tetradecanoyloxy)tetradecanoate | C54H79Cl7NO14P | 详情 | 详情 | |
| (C) | 38221 | 1,1,1-trichloro-2-[(chlorocarbonyl)oxy]-2-methylpropane | C5H6Cl4O2 | 详情 | 详情 |
合成路线9
该中间体在本合成路线中的序号：(IV)D,L-Glutamic acid (I) was sequentially protected as the gamma-allyl ester (III), upon treatment with allyl alcohol (II) and chlorotrimethylsilane, followed by conversion to the trichloroethyl carbamate (V) by means of chloroformate (IV), and then reaction of (V) with benzyl bromide to afford the alpha-benzyl ester (VI). Deprotection of the trichloroethyl carbamate of (VI) by treatment with zinc dust and HOAc and subsequent condensation of the resulting amine with decanoyl chloride (VII) furnished amide (VIII). The allyl ester of (VIII) was then selectively cleaved by using tetrakistriphenylphosphine palladium(0) and morpholine to give carboxylic acid (IX). trans-1,2-Diaminocyclohexane (X) was protected as the mono tert-butyl carbamate (XI) and then coupled with acid (IX) in the presence of diethylphosphoryl cyanide to yield amide (XII). After acidic Boc cleavage of (XII), coupling of the resulting amine with 2,5-diphenyloxazole-4-carboxylic acid (XIII) by means of bromo-tris(pyrrolidino)phosphonium hexafluorophosphate (PyBroP) afforded (XIV). Finally, hydrolysis of the benzyl ester of (XIV) with LiOH provided the corresponding carboxylic acid.
| 【1】 Ducruet, A.P.; Yokokawa, F.; Rice, R.L.; tamura, K.; Lazo, J.S.; Wipf, P.; Yokokama, S.; Identification of new Cdc25 dual specificity phosphatase inhibitors in a targeted small molecule array. Bioorg Med Chem 2000, 8, 6, 1451. |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 28752 | DL-2-Amino propane dicarboxylic acid; DL-2-Aminopentanoic acid; glutamic acid; DL-glutamic acid; (+/-)-2-Aminoglutaric acid | 617-65-2 | C5H9NO4 | 详情 | 详情 |
| (II) | 12234 | 2-Propen-1-ol; Allyl alcohol | 107-18-6 | C3H6O | 详情 | 详情 |
| (III) | 43406 | 5-(allyloxy)-5-oxonorvaline | C8H13NO4 | 详情 | 详情 | |
| (IV) | 13664 | 1,1,1-Trichloro-2-[(chlorocarbonyl)oxy]ethane; 2,2,2-Trichloroethyl chloroformate | 17341-93-4 | C3H2Cl4O2 | 详情 | 详情 |
| (V) | 43399 | 5-(allyloxy)-5-oxo-N-[(2,2,2-trichloroethoxy)carbonyl]norvaline | C11H14Cl3NO6 | 详情 | 详情 | |
| (VI) | 43400 | 5-allyl 1-benzyl 2-[[(2,2,2-trichloroethoxy)carbonyl]amino]pentanedioate | C18H20Cl3NO6 | 详情 | 详情 | |
| (VII) | 28271 | decanoyl chloride | 112-13-0 | C10H19ClO | 详情 | 详情 |
| (VIII) | 43401 | 5-allyl 1-benzyl 2-(decanoylamino)pentanedioate | C25H37NO5 | 详情 | 详情 | |
| (IX) | 43402 | 5-(benzyloxy)-4-(decanoylamino)-5-oxopentanoic acid | C22H33NO5 | 详情 | 详情 | |
| (X) | 11300 | 2-hydroxyethyl 4-hydroxy-1,1-dioxo-1,2-dihydro-1lambda(6),2-benzothiazine-3-carboxylate | C11H11NO6S | 详情 | 详情 | |
| (XI) | 43403 | tert-butyl (1R,2R)-2-aminocyclohexylcarbamate | C11H22N2O2 | 详情 | 详情 | |
| (XII) | 43404 | benzyl 5-([(1R,2R)-2-[(tert-butoxycarbonyl)amino]cyclohexyl]amino)-2-(decanoylamino)-5-oxopentanoate | C33H53N3O6 | 详情 | 详情 | |
| (XIII) | 28277 | 2,5-diphenyl-1,3-oxazole-4-carboxylic acid | C16H11NO3 | 详情 | 详情 | |
| (XIV) | 43405 | benzyl 2-(decanoylamino)-5-[((1R,2R)-2-[[(2,5-diphenyl-1,3-oxazol-4-yl)carbonyl]amino]cyclohexyl)amino]-5-oxopentanoate | C44H54N4O6 | 详情 | 详情 |
合成路线10
该中间体在本合成路线中的序号：(IV)D,L-Glutamic acid (I) was sequentially protected as the gamma-allyl ester (III), upon treatment with allyl alcohol (II) and chlorotrimethylsilane, followed by conversion to the trichloroethyl carbamate (V) by means of chloroformate (IV), and then reaction of (V) with benzyl bromide to afford the alpha-benzyl ester (VI). Deprotection of the trichloroethyl carbamate of (VI) by treatment with zinc dust and HOAc and subsequent condensation of the resulting amine with decanoyl chloride (VII) furnished amide (VIII). The allyl ester of (VIII) was then selectively cleaved by using tetrakistriphenylphosphine palladium(0) and morpholine to give carboxylic acid (IX). trans-1,4-Diaminocyclohexane (X) was protected as the mono tert-butyl carbamate (XI) and then coupled with acid (IX) in the presence of diethylphosphoryl cyanide to yield amide (XII). After acidic Boc cleavage of (XII), coupling of the resulting amine with 2,5-diphenyloxazole-4-carboxylic acid (XIII) by means of bromo-tris(pyrrolidino)phosphonium hexafluorophosphate (PyBroP) afforded (XIV). Finally, hydrolysis of the benzyl ester of (XIV) with LiOH provided the corresponding carboxylic acid.
| 【1】 Ducruet, A.P.; Yokokawa, F.; Rice, R.L.; tamura, K.; Lazo, J.S.; Wipf, P.; Yokokama, S.; Identification of new Cdc25 dual specificity phosphatase inhibitors in a targeted small molecule array. Bioorg Med Chem 2000, 8, 6, 1451. |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 28752 | DL-2-Amino propane dicarboxylic acid; DL-2-Aminopentanoic acid; glutamic acid; DL-glutamic acid; (+/-)-2-Aminoglutaric acid | 617-65-2 | C5H9NO4 | 详情 | 详情 |
| (II) | 12234 | 2-Propen-1-ol; Allyl alcohol | 107-18-6 | C3H6O | 详情 | 详情 |
| (III) | 43406 | 5-(allyloxy)-5-oxonorvaline | C8H13NO4 | 详情 | 详情 | |
| (IV) | 13664 | 1,1,1-Trichloro-2-[(chlorocarbonyl)oxy]ethane; 2,2,2-Trichloroethyl chloroformate | 17341-93-4 | C3H2Cl4O2 | 详情 | 详情 |
| (V) | 43399 | 5-(allyloxy)-5-oxo-N-[(2,2,2-trichloroethoxy)carbonyl]norvaline | C11H14Cl3NO6 | 详情 | 详情 | |
| (VI) | 43400 | 5-allyl 1-benzyl 2-[[(2,2,2-trichloroethoxy)carbonyl]amino]pentanedioate | C18H20Cl3NO6 | 详情 | 详情 | |
| (VII) | 28271 | decanoyl chloride | 112-13-0 | C10H19ClO | 详情 | 详情 |
| (VIII) | 43401 | 5-allyl 1-benzyl 2-(decanoylamino)pentanedioate | C25H37NO5 | 详情 | 详情 | |
| (IX) | 43402 | 5-(benzyloxy)-4-(decanoylamino)-5-oxopentanoic acid | C22H33NO5 | 详情 | 详情 | |
| (X) | 43407 | 4-aminocyclohexylamine; 1,4-cyclohexanediamine | 3114-70-3 | C6H14N2 | 详情 | 详情 |
| (XI) | 43408 | tert-butyl 4-aminocyclohexylcarbamate | C11H22N2O2 | 详情 | 详情 | |
| (XII) | 43409 | benzyl 5-([4-[(tert-butoxycarbonyl)amino]cyclohexyl]amino)-2-(decanoylamino)-5-oxopentanoate | C33H53N3O6 | 详情 | 详情 | |
| (XIII) | 28277 | 2,5-diphenyl-1,3-oxazole-4-carboxylic acid | C16H11NO3 | 详情 | 详情 | |
| (XIV) | 43410 | benzyl 2-(decanoylamino)-5-[(4-[[(2,5-diphenyl-1,3-oxazol-4-yl)carbonyl]amino]cyclohexyl)amino]-5-oxopentanoate | C44H54N4O6 | 详情 | 详情 |