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【结 构 式】 
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【分子编号】40575 【品名】N-[tert-butyl(dimethyl)silyl]-2,2,2-trifluoro-N-methylacetamide 【CA登记号】77377-52-7 |
【 分 子 式 】C9H18F3NOSi 【 分 子 量 】241.3287696 【元素组成】C 44.79% H 7.52% F 23.62% N 5.8% O 6.63% Si 11.64% |
与该中间体有关的原料药合成路线共 1 条
合成路线1
该中间体在本合成路线中的序号：(B)The cyclization of (XXII) by means of CsF in DMSO gives the tris macrocyclic compound (XXIII), which simultaneously eliminates the TEOC protecting group yielding (XXIV) with a free amino group. The silylation of the OH group of (XXIV) with CF3CO-N(Me)-TBDMS (B) affords the silyl ether (XXV), which is protected at its amino group with Troc-Cl (C) providing the fully protected compound (XXVI).
| 【1】 Boger, D.L.; et al.; First and second generation total synthesis of the teicoplanin aglycon. J Am Chem Soc 2001, 123, 9, 1862. |
| 【2】 Boger, D.L.; et al.; Total synthesis of the teicoplanin aglycon. J Am Chem Soc 2000, 122, 30, 7416. |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (B) | 40575 | N-[tert-butyl(dimethyl)silyl]-2,2,2-trifluoro-N-methylacetamide | 77377-52-7 | C9H18F3NOSi | 详情 | 详情 |
| (XXII) | 40572 | C83H90ClFN8O24 | 详情 | 详情 | ||
| (XXIII) | 40573 | C83H89ClN8O24 | 详情 | 详情 | ||
| (XXIV) | 40574 | C80H85ClN8O23 | 详情 | 详情 | ||
| (XXV) | 40576 | C86H99ClN8O23Si | 详情 | 详情 | ||
| (XXVI) | 40577 | C89H100Cl4N8O25Si | 详情 | 详情 | ||
| (C) | 13664 | 1,1,1-Trichloro-2-[(chlorocarbonyl)oxy]ethane; 2,2,2-Trichloroethyl chloroformate | 17341-93-4 | C3H2Cl4O2 | 详情 | 详情 |
Extended Information