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【结 构 式】

【分子编号】40575

【品名】N-[tert-butyl(dimethyl)silyl]-2,2,2-trifluoro-N-methylacetamide

【CA登记号】77377-52-7

【 分 子 式 】C9H18F3NOSi

【 分 子 量 】241.3287696

【元素组成】C 44.79% H 7.52% F 23.62% N 5.8% O 6.63% Si 11.64%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号:(B)

The cyclization of (XXII) by means of CsF in DMSO gives the tris macrocyclic compound (XXIII), which simultaneously eliminates the TEOC protecting group yielding (XXIV) with a free amino group. The silylation of the OH group of (XXIV) with CF3CO-N(Me)-TBDMS (B) affords the silyl ether (XXV), which is protected at its amino group with Troc-Cl (C) providing the fully protected compound (XXVI).

1 Boger, D.L.; et al.; First and second generation total synthesis of the teicoplanin aglycon. J Am Chem Soc 2001, 123, 9, 1862.
2 Boger, D.L.; et al.; Total synthesis of the teicoplanin aglycon. J Am Chem Soc 2000, 122, 30, 7416.
中间体序号 中间体编号 品名 CAS号 分子式 供应商 用于合成
(B) 40575 N-[tert-butyl(dimethyl)silyl]-2,2,2-trifluoro-N-methylacetamide 77377-52-7 C9H18F3NOSi 详情 详情
(XXII) 40572   C83H90ClFN8O24 详情 详情
(XXIII) 40573   C83H89ClN8O24 详情 详情
(XXIV) 40574   C80H85ClN8O23 详情 详情
(XXV) 40576   C86H99ClN8O23Si 详情 详情
(XXVI) 40577   C89H100Cl4N8O25Si 详情 详情
(C) 13664 1,1,1-Trichloro-2-[(chlorocarbonyl)oxy]ethane; 2,2,2-Trichloroethyl chloroformate 17341-93-4 C3H2Cl4O2 详情 详情
Extended Information