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【结 构 式】

【分子编号】13578

【品名】2-bromoethyl 2-amino-6-[(4-fluorobenzyl)amino]-3-pyridinylcarbamate

【CA登记号】

【 分 子 式 】C15H16BrFN4O2

【 分 子 量 】383.2202032

【元素组成】C 47.01% H 4.21% Br 20.85% F 4.96% N 14.62% O 8.35%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号:(VI)

D-19274 can be obtained in a 6-step synthesis starting from 2,6-dichloropyridine (I). Compound (I) is nitrated with HNO3/H2SO4 yielding 2,6-dichloro-3-nitropyridine (II). Subsequent reaction with ammonia and 4-fluorobenzylamine leads to 2-amino-3-nitro-6-(4-fluorobenzylamino)pyridine (IV), which is hydrogenated using Raney Nickel as catalyst to the corresponding 3-amino derivative (V), which reacts with 2-bromoethyl chloroformate to 2-bromoethyl [N-(2-amino-6-(4-fluorobenzylamino)pyridin-3-yl)]carbamate hydrochloride (VI). (VI) is then treated with excess NaOH at 35 C, followed by treatment with isopropanol HCl to give the desired D-19274.

1 Engel, J.; Emig, P.; Nickel, B.; Szelenyi, I. (Asta Medica AG); 3-(N-heterocyclyl)-2,6-diaminopyridines and N-oxides, their preparation and their use as medicines. DE 3915184; EP 0343429; JP 1990017186; US 4923858 .
2 Emig, P.; Engel, J.; Nickel, B.; Szelenyi, I.; Werner, U.; D-19274. Drugs Fut 1990, 15, 3, 223.
中间体序号 中间体编号 品名 CAS号 分子式 供应商 用于合成
31095 4-fluorobenzylamine; (4-fluorophenyl)methanamine 140-75-0 C7H8FN 详情 详情
63775 1-bromo-2-[(chlorocarbonyl)oxy]ethane C3H4BrClO2 详情 详情
(I) 13573 2,6-Dichloropyridine 2402-78-0 C5H3Cl2N 详情 详情
(II) 13574 2,6-Dichloro-3-nitropyridine 16013-85-7 C5H2Cl2N2O2 详情 详情
(III) 13575 6-Chloro-3-nitro-2-pyridinamine; 2-Amino-6-chloro-3-nitropyridine; 6-Chloro-3-nitro-2-pyridinylamine 27048-04-0 C5H4ClN3O2 详情 详情
(IV) 13576 N(6)-(4-Fluorobenzyl)-3-nitro-2,6-pyridinediamine; N-(6-Amino-5-nitro-2-pyridinyl)-N-(4-fluorobenzyl)amine C12H11FN4O2 详情 详情
(V) 13577 N(6)-(4-Fluorobenzyl)-2,3,6-pyridinetriamine; 2-Amino-6-[(4-fluorobenzyl)amino]-3-pyridinylamine C12H13FN4 详情 详情
(VI) 13578 2-bromoethyl 2-amino-6-[(4-fluorobenzyl)amino]-3-pyridinylcarbamate C15H16BrFN4O2 详情 详情
Extended Information