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【结 构 式】 
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【分子编号】17394 【品名】1-(2-bromoethyl)-4-fluorobenzene 【CA登记号】 |
【 分 子 式 】C8H8BrF 【 分 子 量 】203.0539232 【元素组成】C 47.32% H 3.97% Br 39.35% F 9.36% |
合成路线1
该中间体在本合成路线中的序号：(II)MDL-100907 can be obtained by several different ways: 1) The condensation of piperidine-4-carboxamide (I) with 2-(4-fluorophenyl)ethyl bromide (II) by means of K2CO3 in hot DMF gives 1-[2-(4-fluorophenyl)ethyl]piperidine-4-carboxamide (III), which by reaction with refluxing POCl3 is converted into the nitrile (IV). The reduction of (IV) with diisobutyl aluminum hydride (DIBAL) in THF affords the aldehyde (V), which by condensation with 1,2-dimethoxybenzene (veratrole) (VI) by means of BuLi in THF affords racemic MDL-100907 (VII). The esterification of (VII) with (S)-2-methoxy-2-phenylacetic acid (VIII) by means of dicyclohexylcarbodiimide (DCC) and dimethyl-aminopyridine (DMAP) in refluxing CHCl3 affords a mixture of diastereomers that is submitted to column chromatography over silica gel to afford the pure diastereomer (IX). Finally, (IX) is saponified with K2CO3 in methanol/ water
| 【1】 Castaner, J.; Sorbera, L.A.; Silvestre, J.S.; MDL-100907. Drugs Fut 1998, 23, 9, 955. |
| 【2】 Carr, A.A.; Kane, J.M.; Hay, D.A. (Merrell Pharmaceuticals, Inc.); (+)-*-(2,3-Dimethoxyphenyl)-1-[2-(4-fluorophenyl)ethyl]-4-piperidinemethanol. EP 0531410; JP 1993507482; US 5134149; WO 9118602 . |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 11762 | 4-Piperidinecarboxamide; Isonipecotamide | 39546-32-2 | C6H12N2O | 详情 | 详情 |
| (II) | 17394 | 1-(2-bromoethyl)-4-fluorobenzene | C8H8BrF | 详情 | 详情 | |
| (III) | 17395 | 1-(4-fluorophenethyl)-4-piperidinecarboxamide | C14H19FN2O | 详情 | 详情 | |
| (IV) | 17396 | 1-(4-fluorophenethyl)-4-piperidinecarbonitrile | C14H17FN2 | 详情 | 详情 | |
| (V) | 17397 | 1-(4-fluorophenethyl)-4-piperidinecarbaldehyde | C14H18FNO | 详情 | 详情 | |
| (VI) | 17398 | 2-methoxyphenyl methyl ether; Veratrole; 1,2-dimethoxybenzene | 91-16-7 | C8H10O2 | 详情 | 详情 |
| (VII) | 17399 | (2,3-dimethoxyphenyl)[1-(4-fluorophenethyl)-4-piperidinyl]methanol | C22H28FNO3 | 详情 | 详情 | |
| (VIII) | 17400 | (2S)-2-methoxy-2-phenylethanoic acid | C9H10O3 | 详情 | 详情 | |
| (IX) | 17401 | (R)-(2,3-dimethoxyphenyl)[1-(4-fluorophenethyl)-4-piperidinyl]methyl (2S)-2-methoxy-2-phenylethanoate | C31H36FNO5 | 详情 | 详情 |
合成路线2
该中间体在本合成路线中的序号：(II)2) Racemic MDL-100907 (VII) can also be obtained by reaction of piperidine-4-carboxylic acid (X) with di-tert-butyl dicarbonate (XI) by means of NaOH in tert-butanol/ water, giving piperidine-1,4-dicarboxylic acid 1-mono-tert-butyl ester (XII), which is treated with N,O-dimethylhydroxylamine (XIII) and carbonyldiimidazole (CDI) in dichloromethane to afford the methoxy(methyl)amide (XIV). The condensation of (XIV) with veratrole (VI) by means of BuLi in THF gives 4-(2,3-dimethoxybenzoyl)-piperidine-1-carboxylic acid tert-butyl ester (XV), which is decarboxylated by means of trifluoroacetic acid, yielding ketone (XVI). The condensation of (XVI) with 2-(4-fluorophenyl)ethyl bromide (II) by means of K2CO3 in DMF affords 1-(2,3-dimethoxyphenyl)-1-[1-[2-(4-fluorophenyl)-ethyl]piperidin-4-yl]methanone (XVII). Finally, this compound is reduced with NaBH4 in methanol
| 【1】 Castaner, J.; Sorbera, L.A.; Silvestre, J.S.; MDL-100907. Drugs Fut 1998, 23, 9, 955. |
| 【2】 Carr, A.A.; Kane, J.M.; Hay, D.A. (Merrell Pharmaceuticals, Inc.); (+)-*-(2,3-Dimethoxyphenyl)-1-[2-(4-fluorophenyl)ethyl]-4-piperidinemethanol. EP 0531410; JP 1993507482; US 5134149; WO 9118602 . |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (II) | 17394 | 1-(2-bromoethyl)-4-fluorobenzene | C8H8BrF | 详情 | 详情 | |
| (VI) | 17398 | 2-methoxyphenyl methyl ether; Veratrole; 1,2-dimethoxybenzene | 91-16-7 | C8H10O2 | 详情 | 详情 |
| (VII) | 17399 | (2,3-dimethoxyphenyl)[1-(4-fluorophenethyl)-4-piperidinyl]methanol | C22H28FNO3 | 详情 | 详情 | |
| (X) | 17402 | 4-nipecotic acid;piperidine-4-carboxylic acid;p-nipecotic acid; Isonipecotic acid; Hexahydroisonicotinic acid; 4-Piperidinecarboxylic acid | 498-94-2 | C6H11NO2 | 详情 | 详情 |
| (XI) | 13214 | Di-tert-butyldicarbonate; Dicarbonic acid bis(1,1-dimethylethyl) ester; dicarbonic acid di-tert-butyl ester pyrocarbonic acid di-tert-butyl ester; bis(1,1-dimethylethyl) dicarbonate di-tert-butyl pyrocarbonate | 24424-99-5 | C10H18O5 | 详情 | 详情 |
| (XII) | 17404 | 1-(tert-butoxycarbonyl)-4-piperidinecarboxylic acid; 1-BOC-piperidine-4-carboxylic acid; N-Boc-isonipecotic acid | 84358-13-4 | C11H19NO4 | 详情 | 详情 |
| (XIII) | 13361 | (Methoxyamino)methane; N,O-Dimethylhydroxylamine | 1117-97-1 | C2H7NO | 详情 | 详情 |
| (XIV) | 17406 | tert-butyl 4-[[methoxy(methyl)amino]carbonyl]tetrahydro-1(2H)-pyridinecarboxylate | C13H24N2O4 | 详情 | 详情 | |
| (XV) | 17407 | tert-butyl 4-(2,3-dimethoxybenzoyl)tetrahydro-1(2H)-pyridinecarboxylate | C19H27NO5 | 详情 | 详情 | |
| (XVI) | 17408 | (2,3-dimethoxyphenyl)(4-piperidinyl)methanone | C14H19NO3 | 详情 | 详情 | |
| (XVII) | 17409 | (2,3-dimethoxyphenyl)[1-(4-fluorophenethyl)-4-piperidinyl]methanone | C22H26FNO3 | 详情 | 详情 |
合成路线3
该中间体在本合成路线中的序号：(II)3) Racemic MDL-100907 (VII) can also be obtained as follows: The reaction of piperidine-4-carboxylic acid ethyl ester (XVIII) with the previously mentioned bromide (II) by means of K2CO3 as before gives 1-[2-(4-fluorophenyl)ethyl]piperidine-4-carboxylic acid ethyl ester (XIX), which is treated with N,O-dimethylhydroxylamine (XIII) to afford carboxamide (XX). The condensation of (XX) with veratrole (VI) by means of BuLi as before yields the ketonic precursor (XVII), which is finally reduced as before. 4) [11C]-Radiolabeled MDL-100907 can be obtained as follows: Racemic MDL-100907 (VII) is treated with L-Selectride in THF, yielding racemic 1-[1-[2-(4-fluorophenyl)ethyl]piperidin-4-yl]-1-(3-hydroxy-2-methoxy-phenyl)methanol (rac-XXI), which is submitted to semi-preparative HPLC separation over Chiracel OD, affording pure (R-XXI). Finally, this compound is methylated with [11C]-methyl iodide and KOH in HMPA. If this methylation is performed with nonlabeled methyl iodide, MDL-100907 is obtained. 5) The radiolabeling of phenol (R-XXI) can also be performed with better yields using [11C]-methyl trifluoromethanesulfonate (XXII) as methylating agent. Triflate (XXII) is obtained by reaction of silver triflate with [11C]-methyl iodide.
| 【1】 Mathis, C.A.; Mahmood, K.; Price, J.C.; Huang, Y.; Gerdes, J.M.; Simpson, N.R.; Synthesis and preliminary in vivo evaluation of [11C]MDL 100907: A potent and selective radioligand for the 5-HT2A receptor system. Med Chem Res 1996, 6, 1, 1-10. |
| 【2】 Castaner, J.; Sorbera, L.A.; Silvestre, J.S.; MDL-100907. Drugs Fut 1998, 23, 9, 955. |
| 【3】 Hiyama, T.; Minami, T.; Hanamoto, T.; Reddy, G.B. (Sagami Chemical Research Center); Optically active esters of 7-substd. 3,5-difunctionalized 6-heptenoic acids. EP 0475627 . |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (II) | 17394 | 1-(2-bromoethyl)-4-fluorobenzene | C8H8BrF | 详情 | 详情 | |
| (VI) | 17398 | 2-methoxyphenyl methyl ether; Veratrole; 1,2-dimethoxybenzene | 91-16-7 | C8H10O2 | 详情 | 详情 |
| (VII) | 17399 | (2,3-dimethoxyphenyl)[1-(4-fluorophenethyl)-4-piperidinyl]methanol | C22H28FNO3 | 详情 | 详情 | |
| (XIII) | 13361 | (Methoxyamino)methane; N,O-Dimethylhydroxylamine | 1117-97-1 | C2H7NO | 详情 | 详情 |
| (XVII) | 17409 | (2,3-dimethoxyphenyl)[1-(4-fluorophenethyl)-4-piperidinyl]methanone | C22H26FNO3 | 详情 | 详情 | |
| (XVIII) | 17410 | Ethyl isonipecotate; ethyl 4-piperidinecarboxylate | 1126-09-6 | C8H15NO2 | 详情 | 详情 |
| (XIX) | 17411 | ethyl 1-(4-fluorophenethyl)-4-piperidinecarboxylate | C16H22FNO2 | 详情 | 详情 | |
| (XX) | 17412 | 1-(4-fluorophenethyl)-N-methoxy-N-methyl-4-piperidinecarboxamide | C16H23FN2O2 | 详情 | 详情 | |
| (XXI) | 17413 | 3-[(R)-[1-(4-fluorophenethyl)-4-piperidinyl](hydroxy)methyl]-2-methoxyphenol | C21H26FNO3 | 详情 | 详情 | |
| (XXII) | 17414 | methyl trifluoromethane sulfonate; methyl trifluoromethanesulfonate | 333-27-7 | C2H3F3O3S | 详情 | 详情 |
| (XXII) | 45233 | methyl trifluoromethanesulfonate | C2H3F3O3S | 详情 | 详情 |
合成路线4
该中间体在本合成路线中的序号：(I)The synthesis of MDL-100907 [11C]-labeled at the 2'-methoxy group has been reported: Condensation of 2-(4-fluorophenyl)ethyl bromide (I) with piperidine-4-carboxylic acid ethyl ester (II) by means of K2CO3 in DMF gives 1-[2-(4-fluorophenyl)ethyl]piperidine-4-carboxylic acid ethyl ester (III), which is treated with N,O-dimethylhydroxylamine and ethylmagnesium bromide in THF to yield compound (IV). Condensation of (IV) with veratrole (V) by means of BuLi in THF affords the 4-benzoylpiperidine derivative (VI), which is reduced with NaBH4 in methanol to give the racemic carbinol (VII). Optical resolution of (VII) by esterification with (S)-2-methoxy-2-phenylacetic acid (VIII) by means of DCC and DMAP in chloroform followed by column chromatography yields the diastereomer (IX), which is hydrolyzed with K2CO3 in methanol to afford MDL-100907 (X). Selective demethylation of (X) with L-selectride in THF gives the 2'-hydroxy derivative (XI), which is finally remethylated with [11C]-methyl iodide and K2CO3 in methanol.
| 【1】 Mathis, C.A.; Huang, Y.Y.; Mahmood, K.; An efficient synthesis of the precursors of [11C]MDL 100907 labeled in two specific positions. J Label Compd Radiopharm 1999, 42, 10, 949. |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 17394 | 1-(2-bromoethyl)-4-fluorobenzene | C8H8BrF | 详情 | 详情 | |
| (II) | 17410 | Ethyl isonipecotate; ethyl 4-piperidinecarboxylate | 1126-09-6 | C8H15NO2 | 详情 | 详情 |
| (III) | 17411 | ethyl 1-(4-fluorophenethyl)-4-piperidinecarboxylate | C16H22FNO2 | 详情 | 详情 | |
| (IV) | 17412 | 1-(4-fluorophenethyl)-N-methoxy-N-methyl-4-piperidinecarboxamide | C16H23FN2O2 | 详情 | 详情 | |
| (V) | 40496 | tert-butyl(2-methoxyphenoxy)diphenylsilane; tert-butyl(diphenyl)silyl 2-methoxyphenyl ether | C23H26O2Si | 详情 | 详情 | |
| (VI) | 17409 | (2,3-dimethoxyphenyl)[1-(4-fluorophenethyl)-4-piperidinyl]methanone | C22H26FNO3 | 详情 | 详情 | |
| (VII) | 17399 | (2,3-dimethoxyphenyl)[1-(4-fluorophenethyl)-4-piperidinyl]methanol | C22H28FNO3 | 详情 | 详情 | |
| (VIII) | 17400 | (2S)-2-methoxy-2-phenylethanoic acid | C9H10O3 | 详情 | 详情 | |
| (IX) | 17401 | (R)-(2,3-dimethoxyphenyl)[1-(4-fluorophenethyl)-4-piperidinyl]methyl (2S)-2-methoxy-2-phenylethanoate | C31H36FNO5 | 详情 | 详情 | |
| (X) | 40494 | (R)-(2,3-dimethoxyphenyl)[1-(4-fluorophenethyl)-4-piperidinyl]methanol | C22H28FNO3 | 详情 | 详情 | |
| (XI) | 40495 | 2-[(R)-[1-(4-fluorophenethyl)-4-piperidinyl](hydroxy)methyl]-6-methoxyphenol | C21H26FNO3 | 详情 | 详情 |
合成路线5
该中间体在本合成路线中的序号：(I)The synthesis of MDL-100907 [11C]-labeled at the 3'-methoxy group has been described: Condensation of 2-(4-fluorophenyl)ethyl bromide (I) with piperidine-4-carboxylic acid ethyl ester (II) by means of K2CO3 in DMF gives 1-[2-(4-fluorophenyl)ethyl]piperidine-4-carboxylic acid ethyl ester (III), which is treated with N,O-dimethylhydroxylamine and ethylmagnesium bromide in THF yielding the carbohydroxamic ester (IV). The condensation of (IV) with the silylated guaiacole (V) by means of n-BuLi in THF affords the 4-benzoylpiperidine (VI), which is reduced with NaBH4 in methanol giving the racemic carbinol (VII). Optical resolution of (VII) by esterification with (S)-2-methoxy-2-phenylacetic acid (VIII) by means of DCC and DMAP in chloroform followed by column chromatography yields the diastereomer (IX), which is simultaneously hydrolyzed and desilylated with K2CO3 in methanol affording the chiral carbinol (X). Finally, (X) is methylated with [11C]-methyl iodide and K2CO3 in methanol.
| 【1】 Mathis, C.A.; Huang, Y.Y.; Mahmood, K.; An efficient synthesis of the precursors of [11C]MDL 100907 labeled in two specific positions. J Label Compd Radiopharm 1999, 42, 10, 949. |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 17394 | 1-(2-bromoethyl)-4-fluorobenzene | C8H8BrF | 详情 | 详情 | |
| (II) | 17410 | Ethyl isonipecotate; ethyl 4-piperidinecarboxylate | 1126-09-6 | C8H15NO2 | 详情 | 详情 |
| (III) | 17411 | ethyl 1-(4-fluorophenethyl)-4-piperidinecarboxylate | C16H22FNO2 | 详情 | 详情 | |
| (IV) | 17412 | 1-(4-fluorophenethyl)-N-methoxy-N-methyl-4-piperidinecarboxamide | C16H23FN2O2 | 详情 | 详情 | |
| (V) | 40496 | tert-butyl(2-methoxyphenoxy)diphenylsilane; tert-butyl(diphenyl)silyl 2-methoxyphenyl ether | C23H26O2Si | 详情 | 详情 | |
| (VI) | 40497 | (3-[[tert-butyl(diphenyl)silyl]oxy]-2-methoxyphenyl)[1-(4-fluorophenethyl)-4-piperidinyl]methanone | C37H42FNO3Si | 详情 | 详情 | |
| (VII) | 40498 | (3-[[tert-butyl(diphenyl)silyl]oxy]-2-methoxyphenyl)[1-(4-fluorophenethyl)-4-piperidinyl]methanol | C37H44FNO3Si | 详情 | 详情 | |
| (VIII) | 17401 | (R)-(2,3-dimethoxyphenyl)[1-(4-fluorophenethyl)-4-piperidinyl]methyl (2S)-2-methoxy-2-phenylethanoate | C31H36FNO5 | 详情 | 详情 | |
| (IX) | 40499 | (R)-(3-[[tert-butyl(diphenyl)silyl]oxy]-2-methoxyphenyl)[1-(4-fluorophenethyl)-4-piperidinyl]methyl (2S)-2-methoxy-2-phenylethanoate | C46H52FNO5Si | 详情 | 详情 | |
| (X) | 17413 | 3-[(R)-[1-(4-fluorophenethyl)-4-piperidinyl](hydroxy)methyl]-2-methoxyphenol | C21H26FNO3 | 详情 | 详情 |
合成路线6
该中间体在本合成路线中的序号：(VII)The condensation of 1,2-dimethoxybenzene (I) with 1-(tert-butoxcarbonyl)-N-methoxy-N-methylpiperidine-4-carboxamide (II) by means of BuLi in THF gives the protected benzoylpiperidine (III), which is deprotected by means of TFA to yield the deprotected piperidine (IV). The reduction of the carbonyl group of (IV) by means of NaBH4 in methanol affords the racemic carbinol (V), which is submitted to optical resolution with (+)-di-O,O'-p-toluyltartaric acid, providing the (+)-(R)-carbinol (VI). Finally, this compound is condensed with 2-(4-fluorophenyl)ethyl bromide (VIII) by means of NaHCO3 in hot DMF.
| 【1】 Ullrich, T.; Rice, K.C.; A practical synthesis of the serotonin 5-HT2A receptor antagonist MDL-100907, its enantiomer and their 3-phenolic derivatives as precursors for [11C]labeled PET ligands. Bioorg Med Chem 2000, 8, 10, 2427. |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 17398 | 2-methoxyphenyl methyl ether; Veratrole; 1,2-dimethoxybenzene | 91-16-7 | C8H10O2 | 详情 | 详情 |
| (II) | 17406 | tert-butyl 4-[[methoxy(methyl)amino]carbonyl]tetrahydro-1(2H)-pyridinecarboxylate | C13H24N2O4 | 详情 | 详情 | |
| (III) | 17407 | tert-butyl 4-(2,3-dimethoxybenzoyl)tetrahydro-1(2H)-pyridinecarboxylate | C19H27NO5 | 详情 | 详情 | |
| (IV) | 17408 | (2,3-dimethoxyphenyl)(4-piperidinyl)methanone | C14H19NO3 | 详情 | 详情 | |
| (V) | 52803 | (2,3-dimethoxyphenyl)(4-piperidinyl)methanol | C14H21NO3 | 详情 | 详情 | |
| (VI) | 52804 | (R)-(2,3-dimethoxyphenyl)(4-piperidinyl)methanol | C14H21NO3 | 详情 | 详情 | |
| (VII) | 17394 | 1-(2-bromoethyl)-4-fluorobenzene | C8H8BrF | 详情 | 详情 |
合成路线7
该中间体在本合成路线中的序号：(VI)Condensation of 1-benzyl-4-(3-methoxyphenyl)aminopiperidine (I) with oxalyl chloride, followed by Friedel-Crafts cyclization in the presence of AlCl3, furnished the isatin (II), which was reduced to indole (III) by means of borane-dimethyl sulfide complex. Removal of the N-benzyl protecting group of (III) to afford piperidine (IV) was achieved by treatment with chloroethyl chloroformate, followed by methanolysis of the intermediate chloroethyl carbamate. 4-Fluorophenethyl bromide (VI) was prepared from the corresponding alcohol (V) by means of the reagent generated from N-bromosuccinimide and triphenyl phosphine. Piperidine (IV) was then condensed with bromide (VI) to provide adduct (VII). Finally, the indole ring of (VII) was reduced to the required indoline using borane in THF.
| 【1】 Kimura, T.; Takahashi, K.; Matsunaga, M.; Kawano, K.; Kubota, A.; Kitazawa, N.; Okabe, T.; Ueno, K.; Komatsu, M.; Sasaki, A. (Eisai Co., Ltd.); 1,4-Substd. cyclic amine derivs.. EP 0976732; WO 9843956 . |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 47441 | 1-benzyl-N-(3-methoxyphenyl)-4-piperidinamine; N-(1-benzyl-4-piperidinyl)-N-(3-methoxyphenyl)amine | C19H24N2O | 详情 | 详情 | |
| (II) | 47442 | 1-(1-benzyl-4-piperidinyl)-6-methoxy-1H-indole-2,3-dione | C21H22N2O3 | 详情 | 详情 | |
| (III) | 47443 | 1-(1-benzyl-4-piperidinyl)-1H-indol-6-yl methyl ether; 1-(1-benzyl-4-piperidinyl)-6-methoxy-1H-indole | C21H24N2O | 详情 | 详情 | |
| (IV) | 47444 | 6-methoxy-1-(4-piperidinyl)-1H-indole; methyl 1-(4-piperidinyl)-1H-indol-6-yl ether | C14H18N2O | 详情 | 详情 | |
| (V) | 47445 | 2-(4-fluorophenyl)-1-ethanol | 7589-27-7 | C8H9FO | 详情 | 详情 |
| (VI) | 17394 | 1-(2-bromoethyl)-4-fluorobenzene | C8H8BrF | 详情 | 详情 | |
| (VII) | 47446 | 1-[1-(4-fluorophenethyl)-4-piperidinyl]-6-methoxy-1H-indole; 1-[1-(4-fluorophenethyl)-4-piperidinyl]-1H-indol-6-yl methyl ether | C22H25FN2O | 详情 | 详情 |
合成路线8
该中间体在本合成路线中的序号：(II)Alkylation of 4-(p-fluorobenzoyl)piperidine (I) with p-fluorophenethyl bromide (II) in hot methyl isobutyl ketone provides the disubstituted piperidine (III). Subsequent keto group reduction in (III) by means of NaBH4 furnishes the title carbinol compound.
| 【1】 Fu, X.; Tan, P.-Z.; Kula, N.S.; Baldessarini, R.; Tamagnan, G.; Innis, R.B.; Baldwin, R.M.; Synthesis, receptor potency, and selectivity of halogenated diphenylpiperidines as serotonin 5-HT2A ligands for PET or SPECT brain imaging. J Med Chem 2002, 45, 11, 2319. |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 21497 | (4-Fluorophenyl)(4-piperidinyl)methanone; 4-(4-Fluorobenzoyl)piperidine; 4-(p-Fluorobenzoyl)piperidine | 56346-57-7 | C12H14FNO | 详情 | 详情 |
| (II) | 17394 | 1-(2-bromoethyl)-4-fluorobenzene | C8H8BrF | 详情 | 详情 | |
| (III) | 64558 | [1-(4-fluorophenethyl)-4-piperidinyl](4-fluorophenyl)methanone | C20H21F2NO | 详情 | 详情 |