• English
  • 简体中文
Login Register
Current Location: Home > Feedback Help Print

【结 构 式】

【分子编号】17413

【品名】3-[(R)-[1-(4-fluorophenethyl)-4-piperidinyl](hydroxy)methyl]-2-methoxyphenol

【CA登记号】

【 分 子 式 】C21H26FNO3

【 分 子 量 】359.4407832

【元素组成】C 70.17% H 7.29% F 5.29% N 3.9% O 13.35%

与该中间体有关的原料药合成路线共 2 条

合成路线1

该中间体在本合成路线中的序号:(XXI)

3) Racemic MDL-100907 (VII) can also be obtained as follows: The reaction of piperidine-4-carboxylic acid ethyl ester (XVIII) with the previously mentioned bromide (II) by means of K2CO3 as before gives 1-[2-(4-fluorophenyl)ethyl]piperidine-4-carboxylic acid ethyl ester (XIX), which is treated with N,O-dimethylhydroxylamine (XIII) to afford carboxamide (XX). The condensation of (XX) with veratrole (VI) by means of BuLi as before yields the ketonic precursor (XVII), which is finally reduced as before. 4) [11C]-Radiolabeled MDL-100907 can be obtained as follows: Racemic MDL-100907 (VII) is treated with L-Selectride in THF, yielding racemic 1-[1-[2-(4-fluorophenyl)ethyl]piperidin-4-yl]-1-(3-hydroxy-2-methoxy-phenyl)methanol (rac-XXI), which is submitted to semi-preparative HPLC separation over Chiracel OD, affording pure (R-XXI). Finally, this compound is methylated with [11C]-methyl iodide and KOH in HMPA. If this methylation is performed with nonlabeled methyl iodide, MDL-100907 is obtained. 5) The radiolabeling of phenol (R-XXI) can also be performed with better yields using [11C]-methyl trifluoromethanesulfonate (XXII) as methylating agent. Triflate (XXII) is obtained by reaction of silver triflate with [11C]-methyl iodide.

1 Mathis, C.A.; Mahmood, K.; Price, J.C.; Huang, Y.; Gerdes, J.M.; Simpson, N.R.; Synthesis and preliminary in vivo evaluation of [11C]MDL 100907: A potent and selective radioligand for the 5-HT2A receptor system. Med Chem Res 1996, 6, 1, 1-10.
2 Castaner, J.; Sorbera, L.A.; Silvestre, J.S.; MDL-100907. Drugs Fut 1998, 23, 9, 955.
3 Hiyama, T.; Minami, T.; Hanamoto, T.; Reddy, G.B. (Sagami Chemical Research Center); Optically active esters of 7-substd. 3,5-difunctionalized 6-heptenoic acids. EP 0475627 .
中间体序号 中间体编号 品名 CAS号 分子式 供应商 用于合成
(II) 17394 1-(2-bromoethyl)-4-fluorobenzene C8H8BrF 详情 详情
(VI) 17398 2-methoxyphenyl methyl ether; Veratrole; 1,2-dimethoxybenzene 91-16-7 C8H10O2 详情 详情
(VII) 17399 (2,3-dimethoxyphenyl)[1-(4-fluorophenethyl)-4-piperidinyl]methanol C22H28FNO3 详情 详情
(XIII) 13361 (Methoxyamino)methane; N,O-Dimethylhydroxylamine 1117-97-1 C2H7NO 详情 详情
(XVII) 17409 (2,3-dimethoxyphenyl)[1-(4-fluorophenethyl)-4-piperidinyl]methanone C22H26FNO3 详情 详情
(XVIII) 17410 Ethyl isonipecotate; ethyl 4-piperidinecarboxylate 1126-09-6 C8H15NO2 详情 详情
(XIX) 17411 ethyl 1-(4-fluorophenethyl)-4-piperidinecarboxylate C16H22FNO2 详情 详情
(XX) 17412 1-(4-fluorophenethyl)-N-methoxy-N-methyl-4-piperidinecarboxamide C16H23FN2O2 详情 详情
(XXI) 17413 3-[(R)-[1-(4-fluorophenethyl)-4-piperidinyl](hydroxy)methyl]-2-methoxyphenol C21H26FNO3 详情 详情
(XXII) 17414 methyl trifluoromethane sulfonate; methyl trifluoromethanesulfonate 333-27-7 C2H3F3O3S 详情 详情
(XXII) 45233 methyl trifluoromethanesulfonate C2H3F3O3S 详情 详情

合成路线2

该中间体在本合成路线中的序号:(X)

The synthesis of MDL-100907 [11C]-labeled at the 3'-methoxy group has been described: Condensation of 2-(4-fluorophenyl)ethyl bromide (I) with piperidine-4-carboxylic acid ethyl ester (II) by means of K2CO3 in DMF gives 1-[2-(4-fluorophenyl)ethyl]piperidine-4-carboxylic acid ethyl ester (III), which is treated with N,O-dimethylhydroxylamine and ethylmagnesium bromide in THF yielding the carbohydroxamic ester (IV). The condensation of (IV) with the silylated guaiacole (V) by means of n-BuLi in THF affords the 4-benzoylpiperidine (VI), which is reduced with NaBH4 in methanol giving the racemic carbinol (VII). Optical resolution of (VII) by esterification with (S)-2-methoxy-2-phenylacetic acid (VIII) by means of DCC and DMAP in chloroform followed by column chromatography yields the diastereomer (IX), which is simultaneously hydrolyzed and desilylated with K2CO3 in methanol affording the chiral carbinol (X). Finally, (X) is methylated with [11C]-methyl iodide and K2CO3 in methanol.

1 Mathis, C.A.; Huang, Y.Y.; Mahmood, K.; An efficient synthesis of the precursors of [11C]MDL 100907 labeled in two specific positions. J Label Compd Radiopharm 1999, 42, 10, 949.
中间体序号 中间体编号 品名 CAS号 分子式 供应商 用于合成
(I) 17394 1-(2-bromoethyl)-4-fluorobenzene C8H8BrF 详情 详情
(II) 17410 Ethyl isonipecotate; ethyl 4-piperidinecarboxylate 1126-09-6 C8H15NO2 详情 详情
(III) 17411 ethyl 1-(4-fluorophenethyl)-4-piperidinecarboxylate C16H22FNO2 详情 详情
(IV) 17412 1-(4-fluorophenethyl)-N-methoxy-N-methyl-4-piperidinecarboxamide C16H23FN2O2 详情 详情
(V) 40496 tert-butyl(2-methoxyphenoxy)diphenylsilane; tert-butyl(diphenyl)silyl 2-methoxyphenyl ether C23H26O2Si 详情 详情
(VI) 40497 (3-[[tert-butyl(diphenyl)silyl]oxy]-2-methoxyphenyl)[1-(4-fluorophenethyl)-4-piperidinyl]methanone C37H42FNO3Si 详情 详情
(VII) 40498 (3-[[tert-butyl(diphenyl)silyl]oxy]-2-methoxyphenyl)[1-(4-fluorophenethyl)-4-piperidinyl]methanol C37H44FNO3Si 详情 详情
(VIII) 17401 (R)-(2,3-dimethoxyphenyl)[1-(4-fluorophenethyl)-4-piperidinyl]methyl (2S)-2-methoxy-2-phenylethanoate C31H36FNO5 详情 详情
(IX) 40499 (R)-(3-[[tert-butyl(diphenyl)silyl]oxy]-2-methoxyphenyl)[1-(4-fluorophenethyl)-4-piperidinyl]methyl (2S)-2-methoxy-2-phenylethanoate C46H52FNO5Si 详情 详情
(X) 17413 3-[(R)-[1-(4-fluorophenethyl)-4-piperidinyl](hydroxy)methyl]-2-methoxyphenol C21H26FNO3 详情 详情
Extended Information