[1-(4-fluorophenethyl)-4-piperidinyl](4-fluorophenyl)methanone -Drug Synthesis Database

【结构式】

【分子编号】64558

【品名】[1-(4-fluorophenethyl)-4-piperidinyl](4-fluorophenyl)methanone

【CA登记号】

【分子式】C₂₀H₂₁F₂NO

【分子量】329.3896864

【元素组成】C 72.93% H 6.43% F 11.54% N 4.25% O 4.86%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号：(III)

Alkylation of 4-(p-fluorobenzoyl)piperidine (I) with p-fluorophenethyl bromide (II) in hot methyl isobutyl ketone provides the disubstituted piperidine (III). Subsequent keto group reduction in (III) by means of NaBH4 furnishes the title carbinol compound.

参考文献中间体

合成目标

【1】 Fu, X.; Tan, P.-Z.; Kula, N.S.; Baldessarini, R.; Tamagnan, G.; Innis, R.B.; Baldwin, R.M.; Synthesis, receptor potency, and selectivity of halogenated diphenylpiperidines as serotonin 5-HT2A ligands for PET or SPECT brain imaging. J Med Chem 2002, 45, 11, 2319.

中间体序号	中间体编号	品名	CAS号	分子式	供应商	用于合成
(I)	21497	(4-Fluorophenyl)(4-piperidinyl)methanone; 4-(4-Fluorobenzoyl)piperidine; 4-(p-Fluorobenzoyl)piperidine	56346-57-7	C₁₂H₁₄FNO	详情	详情
(II)	17394	1-(2-bromoethyl)-4-fluorobenzene		C₈H₈BrF	详情	详情
(III)	64558	[1-(4-fluorophenethyl)-4-piperidinyl](4-fluorophenyl)methanone		C₂₀H₂₁F₂NO	详情	详情

Extended Information