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【结 构 式】 
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【分子编号】69584 【品名】R-b-Hydroxyisobutyric acid;D-b-Hydroxyisobutyric acid;D-(-)-3-Hydroxyisobutyric acid;(R)-3-Hydroxyisobutyric acid;(R)-3-Hydroxy-2-methylpropionic acid;(R)-3-hydroxy-2-methylpropanoic acid 【CA登记号】1910-47-0 |
【 分 子 式 】C4H8O3 【 分 子 量 】104.10572 【元素组成】C 46.15% H 7.75% O 46.11% |
与该中间体有关的原料药合成路线共 2 条
合成路线1
该中间体在本合成路线中的序号：(I)
| 【1】 Shimazaki M,Hasegawa J,Kan K.Synthesis of captopril starting from potically active β-hydroxy acid.Chem Pharm Bull,1982,30:3139. |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 69584 | R-b-Hydroxyisobutyric acid;D-b-Hydroxyisobutyric acid;D-(-)-3-Hydroxyisobutyric acid;(R)-3-Hydroxyisobutyric acid;(R)-3-Hydroxy-2-methylpropionic acid;(R)-3-hydroxy-2-methylpropanoic acid | 1910-47-0 | C4H8O3 | 详情 | 详情 |
| (II) | 69585 | (R)-3-chloro-2-methylpropanoyl chloride | C4H6Cl2O | 详情 | 详情 | |
| (III) | 16731 | L-proline | 147-85-3 | C5H9NO2 | 详情 | 详情 |
| (IV) | 69583 | (S)-1-((S)-3-chloro-2-methylpropanoyl)pyrrolidine-2-carboxylic acid | C9H14ClNO3 | 详情 | 详情 |
合成路线2
该中间体在本合成路线中的序号：(II)
| 【1】 Locher T,Urban EM,Molinari F,et al.Method for praparaing 3-hydroxycarboxylic acids and captopril:WO,Patent 2,000,022,153,2000. |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 69602 | 2-Methyl-1,3-propanediol;1,3-Dihydroxy-2-methylpropane;1,3-Dihydroxyisobutane;2-Methyl-1,3-propanediol;2-Methylpropan-1,3-diol;MPDiol;Methylpropanediol;b-Hydroxyisobutanol | 2163-42-0 | C4H10O2 | 详情 | 详情 |
| (II) | 69584 | R-b-Hydroxyisobutyric acid;D-b-Hydroxyisobutyric acid;D-(-)-3-Hydroxyisobutyric acid;(R)-3-Hydroxyisobutyric acid;(R)-3-Hydroxy-2-methylpropionic acid;(R)-3-hydroxy-2-methylpropanoic acid | 1910-47-0 | C4H8O3 | 详情 | 详情 |
| (III) | 69603 | (R)-3-hydroxy-2-methylpropanoyl chloride | C4H7ClO2 | 详情 | 详情 | |
| (IV) | 16731 | L-proline | 147-85-3 | C5H9NO2 | 详情 | 详情 |
| (V) | 69583 | (S)-1-((S)-3-chloro-2-methylpropanoyl)pyrrolidine-2-carboxylic acid | C9H14ClNO3 | 详情 | 详情 |
Extended Information