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【结 构 式】 
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【分子编号】69054 【品名】6-fluoro-3-hydroxypyrazine-2-carbonitrile compound with dicyclohexylamine 【CA登记号】 |
【 分 子 式 】C5H2FN3O.C12H23N 【 分 子 量 】320.41 【元素组成】C 63.73% H 7.86% F 5.93% N 17.49% O 4.99% |
与该中间体有关的原料药合成路线共 1 条
合成路线1
该中间体在本合成路线中的序号：(VII)Alternatively, regioselective fluoride group substitution in 3,6-difluoropyrazine-2-carbonitrile (VI) using KOAc in the presence of NH4OH leads to the corresponding 3-hydroxypyrazine derivative (VII), isolated as the dicyclohexylamine salt by treatment with DCHA in DMF/H2O. Finally, nitrile (VII) is hydrolyzed using NaOH/H2O2 followed by treatment with HCl .
| 【1】 Furuta, Y., Egawa, H. (Toyama Chemical Co., Ltd.). Nitrogenous heterocyclic carboxamide derivatives or salts thereof and antiviral agents containing both. EP 1112743, US 2002013316, US 6787544, WO 2000010569. |
Extended Information