【结 构 式】 |
【分子编号】69053 【品名】3,6-difluoropyrazine-2-carbonitrile 【CA登记号】 |
【 分 子 式 】C5HF2N3 【 分 子 量 】141.08 【元素组成】C 42.57% H 0.71% F 26.93% N 29.78% |
与该中间体有关的原料药合成路线共 1 条
合成路线1
该中间体在本合成路线中的序号:(VI)Alternatively, regioselective fluoride group substitution in 3,6-difluoropyrazine-2-carbonitrile (VI) using KOAc in the presence of NH4OH leads to the corresponding 3-hydroxypyrazine derivative (VII), isolated as the dicyclohexylamine salt by treatment with DCHA in DMF/H2O. Finally, nitrile (VII) is hydrolyzed using NaOH/H2O2 followed by treatment with HCl .
【1】 Furuta, Y., Egawa, H. (Toyama Chemical Co., Ltd.). Nitrogenous heterocyclic carboxamide derivatives or salts thereof and antiviral agents containing both. EP 1112743, US 2002013316, US 6787544, WO 2000010569. |
Extended Information