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【结 构 式】

【分子编号】68862

【品名】5-amino-2-(4-amino-1,3-dioxoisoindolin-2-yl)-5-oxopentanoic acid

【CA登记号】 

【 分 子 式 】C13H13N3O5

【 分 子 量 】291.26344

【元素组成】C 53.61% H 4.5% N 14.43% O 27.47%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号:(XIII)

Treatment of 3-nitrophthalimide (I) with ethyl chloroformate in the presence of Et3N in DMF produces the N-(ethoxycarbonyl)phthalimide derivative (II), which is condensed with glutamine tert-butyl ester (III) by means of Et3N in refluxing THF to afford the phthaloylglutamine derivative (IV). Hydrolysis of the tert-butyl ester group of compound (IV) with HCl in CH2Cl2 yields the corresponding carboxylic acid (V), which is cyclized by means of SOCl2 in the presence of pyridine and Et3N in CH2Cl2, resulting in the corresponding glutarimide (VI) . Finally, the nitro group of glutarimide (VI) is reduced by catalytic hydrogenation over Pd/C in acetone or with Sn/HCl .
Pure enantiomers of pomalidomide can been prepared using the corresponding enantiomers of glutamine tert-butyl ester (III), as the cyclization of phthaloyl-glutamine (V) takes place without racemization, resulting in the corresponding enantiomeric glutarimides. The nitrophthalimide precursor (VI) can be alternatively obtained by cyclization of N-(benzyloxycarbonyl)glutamine (VII) by means of CDI in refluxing THF to afford the glutarimide derivative (VIII), which is then N-deprotected to 2-aminoglutarimide (IX) by either hydrogenolysis over Pd/C or by treatment with HBr in AcOH. Finally, aminoglutarimide (IX) is condensed with 3-nitrophthalic anhydride (X) using AcOH at reflux .
Cyclization of 3-aminophthalic acid hydrochloride (XI) with 2-aminoglutarimide (IX) using Et3N or imidazole, optionally in the presence of AcOH in acetonitrile .
Condensation of 3-nitrophthalic anhydride (X) with glutamine (XII) in DMF yields N-(3-nitrophthaloyl)glutamine (V), which is reduced with H2 over Pd/C to give the corresponding amine (XIII). Finally, this compound undergoes cyclization by means of CDI .

1 Muller, G.W., Chen, R., Huang, S.-Y. et al. Amino-substituted thalidomide analogs: Potent inhibitors of TNF-alpha production. Bioorg Med Chem Lett 1999, 9(11): 1625-30.
2 Stirling, D.I., Chen, R.S.-C., Muller, G.W. (Celgene Corp.). Substituted 2-(2,6-dioxopiperidin-3-yl)-phthalimides and -1-oxoisoindolines and method of reducing TNFalpha levels. EP 0925294, EP 1285916, EP 2070920, EP 2177517, EP 2305663, JP 2008050368, US 5635517, WO 1998003502.
3 Muller, G.W., Saindane, M.T., Ge, C., Chen, R. (Celgene Corp.). Processes for the preparation of 4-amino-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione compounds. EP 1907373, JP 2008544993, US 2007004920, US 7994327, WO 2007005972.
4 Shah, J.H., Hunsucker, K.A., Conner, B.P. et al. (Children’s Medical Center Corp.). Synthesis of 3-amino-thalidomide and its enantiomers. CA 2430669, EP 1353672, JP 2004536784, JP 2009108077, US 2004147558, US 7812169, WO 2002064083.
中间体序号 中间体编号 品名 CAS号 分子式 供应商 用于合成
(I) 34424 4-nitro-1H-isoindole-1,3(2H)-dione;3-nitrophthalimide 603-62-3 C8H4N2O4 详情 详情
(II) 34425 ethyl 4-nitro-1,3-dioxo-1,3-dihydro-2H-isoindole-2-carboxylate C11H8N2O6 详情 详情
(III) 68855 tert-butyl 2,5-diamino-5-oxopentanoate hydrochloride   C9H18N2O3.HCl 详情 详情
(IV) 68856 tert-butyl 5-amino-2-(4-nitro-1,3-dioxoisoindolin-2-yl)-5-oxopentanoate   C17H19N3O7 详情 详情
(V) 68857 5-amino-2-(4-nitro-1,3-dioxoisoindolin-2-yl)-5-oxopentanoic acid   C13H11N3O7 详情 详情
(VI) 68858 2-(2,6-dioxopiperidin-3-yl)-4-nitroisoindoline-1,3-dione   C13H9N3O6 详情 详情
(VII) 68859 5-amino-2-((benzoyloxy)amino)-5-oxopentanoic acid   C12H14N2O5 详情 详情
(VIII) 68860 3-((benzoyloxy)amino)piperidine-2,6-dione   C12H12N2O4 详情 详情
(IX) 37576 3-amino-2,6-piperidinedione;3-aminopiperidine-2,6-dione;2-amino-Glutarimide;Glutamimide;a-Aminoglutarimide 2353-44-8 C5H8N2O2 详情 详情
(X) 46407 4-nitro-2-benzofuran-1,3-dione;3-nitrophthalic anhydride 641-70-3 C8H3NO5 详情 详情
(XI) 68861 3-aminophthalic acid hydrochloride;3-amino-1,2-Benzenedicarboxylicacid hydrochloride;3-amino-Phthalic acid hydrochloride 6946-22-1 C8H7NO4.HCl 详情 详情
(XII) 24666 glutamine;2,5-diamino-5-oxopentanoic acid C5H10N2O3 详情 详情
(XIII) 68862 5-amino-2-(4-amino-1,3-dioxoisoindolin-2-yl)-5-oxopentanoic acid   C13H13N3O5 详情 详情
Extended Information