(7S)-7-((2S,3R)-2,3-dihydroxy-4-methoxybutan-2-yl)-5-(4-(dimethylamino)phenyl)-7-methyl-3,4,6,7,8,8a,9,10-octahydrophenanthren-2(5H)-one -Drug Synthesis Database

【结构式】

【分子编号】67472

【品名】(7S)-7-((2S,3R)-2,3-dihydroxy-4-methoxybutan-2-yl)-5-(4-(dimethylamino)phenyl)-7-methyl-3,4,6,7,8,8a,9,10-octahydrophenanthren-2(5H)-one

【CA登记号】　

【分子式】C₂₈H₃₉NO₄

【分子量】453.622

【元素组成】C 74.14% H 8.67% N 3.09% O 14.11%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号：(VII)

参考文献中间体

合成目标

【1】 BoDI Jozsef.2009.Industrial method for the synthesis of 17-acetoxy-11β-[4-(dimethylamino)-phenyl]-21-methoxy-19-norpregna-4,9-diene-3,20-dione and the key intermediates of the process. WO 2009001148 A2.

中间体序号	中间体编号	品名	CAS号	分子式	供应商	用于合成
(I)	30502	3,3-Ethylenedioxyestra-5(10),9(11)-dien-17-one	5571-36-8	C₂₀H₂₆O₃	详情	详情
(II)	67467	1-(7-methyl-3,4,6,7,8,8a,9,10-octahydro-1H-spiro[4a,10a-epoxyphenanthrene-2,2'-[1,3]dioxolan]-7-yl)ethanone		C₁₉H₂₆O₄	详情	详情
(III)	67468	(2S)-2-hydroxy-2-((7R,8aR)-7-methyl-3,4,6,7,8,8a,9,10-octahydro-1H-spiro[4a,10a-epoxyphenanthrene-2,2'-[1,3]dioxolan]-7-yl)propanenitrile		C₂₀H₂₇NO₄	详情	详情
(IV)	67469	(2S)-2-((7R,8aR)-7-methyl-3,4,6,7,8,8a,9,10-octahydro-1H-spiro[4a,10a-epoxyphenanthrene-2,2'-[1,3]dioxolan]-7-yl)-2-((trimethylsilyl)oxy)propanenitrile		C₂₃H₃₅NO₄Si	详情	详情
(V)	67470	(2S)-2-((7'S,8a'R,10a'S)-5'-(4-(dimethylamino)phenyl)-10a'-hydroxy-7'-methyl-3',4',5',6',7',8',8a',9',10',10a'-decahydro-1'H-spiro[[1,3]dioxolane-2,2'-phenanthren]-7'-yl)-2-((trimethylsilyl)oxy)propanenitrile		C₃₁H₄₆N₂O₄Si	详情	详情
(VI)	67471	(2S)-2-((7'S,8a'R,10a'S)-5'-(4-(dimethylamino)phenyl)-10a'-hydroxy-7'-methyl-3',4',5',6',7',8',8a',9',10',10a'-decahydro-1'H-spiro[[1,3]dioxolane-2,2'-phenanthren]-7'-yl)-2-((trimethylsilyl)oxy)propanenitrile		C₃₄H₅₅NO₅Si₂	详情	详情
(VII)	67472	(7S)-7-((2S,3R)-2,3-dihydroxy-4-methoxybutan-2-yl)-5-(4-(dimethylamino)phenyl)-7-methyl-3,4,6,7,8,8a,9,10-octahydrophenanthren-2(5H)-one		C₂₈H₃₉NO₄	详情	详情
(VIII)	67473	(7S)-5-(4-(dimethylamino)phenyl)-7-((S)-2-hydroxy-4-methoxy-3-oxobutan-2-yl)-7-methyl-3,4,6,7,8,8a,9,10-octahydrophenanthren-2(5H)-one		C₂₈H₃₇NO₄	详情	详情

Extended Information