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【结 构 式】 
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【分子编号】67470 【品名】(2S)-2-((7'S,8a'R,10a'S)-5'-(4-(dimethylamino)phenyl)-10a'-hydroxy-7'-methyl-3',4',5',6',7',8',8a',9',10',10a'-decahydro-1'H-spiro[[1,3]dioxolane-2,2'-phenanthren]-7'-yl)-2-((trimethylsilyl)oxy)propanenitrile 【CA登记号】 |
【 分 子 式 】C31H46N2O4Si 【 分 子 量 】538.803 【元素组成】C 69.10%% H 8.60% N 5.20% O 11.88% Si 5.21% |
与该中间体有关的原料药合成路线共 1 条
合成路线1
该中间体在本合成路线中的序号：(V)
| 【1】 BoDI Jozsef.2009.Industrial method for the synthesis of 17-acetoxy-11β-[4-(dimethylamino)-phenyl]-21-methoxy-19-norpregna-4,9-diene-3,20-dione and the key intermediates of the process. WO 2009001148 A2. |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 30502 | 3,3-Ethylenedioxyestra-5(10),9(11)-dien-17-one | 5571-36-8 | C20H26O3 | 详情 | 详情 |
| (II) | 67467 | 1-(7-methyl-3,4,6,7,8,8a,9,10-octahydro-1H-spiro[4a,10a-epoxyphenanthrene-2,2'-[1,3]dioxolan]-7-yl)ethanone | C19H26O4 | 详情 | 详情 | |
| (III) | 67468 | (2S)-2-hydroxy-2-((7R,8aR)-7-methyl-3,4,6,7,8,8a,9,10-octahydro-1H-spiro[4a,10a-epoxyphenanthrene-2,2'-[1,3]dioxolan]-7-yl)propanenitrile | C20H27NO4 | 详情 | 详情 | |
| (IV) | 67469 | (2S)-2-((7R,8aR)-7-methyl-3,4,6,7,8,8a,9,10-octahydro-1H-spiro[4a,10a-epoxyphenanthrene-2,2'-[1,3]dioxolan]-7-yl)-2-((trimethylsilyl)oxy)propanenitrile | C23H35NO4Si | 详情 | 详情 | |
| (V) | 67470 | (2S)-2-((7'S,8a'R,10a'S)-5'-(4-(dimethylamino)phenyl)-10a'-hydroxy-7'-methyl-3',4',5',6',7',8',8a',9',10',10a'-decahydro-1'H-spiro[[1,3]dioxolane-2,2'-phenanthren]-7'-yl)-2-((trimethylsilyl)oxy)propanenitrile | C31H46N2O4Si | 详情 | 详情 | |
| (VI) | 67471 | (2S)-2-((7'S,8a'R,10a'S)-5'-(4-(dimethylamino)phenyl)-10a'-hydroxy-7'-methyl-3',4',5',6',7',8',8a',9',10',10a'-decahydro-1'H-spiro[[1,3]dioxolane-2,2'-phenanthren]-7'-yl)-2-((trimethylsilyl)oxy)propanenitrile | C34H55NO5Si2 | 详情 | 详情 | |
| (VII) | 67472 | (7S)-7-((2S,3R)-2,3-dihydroxy-4-methoxybutan-2-yl)-5-(4-(dimethylamino)phenyl)-7-methyl-3,4,6,7,8,8a,9,10-octahydrophenanthren-2(5H)-one | C28H39NO4 | 详情 | 详情 | |
| (VIII) | 67473 | (7S)-5-(4-(dimethylamino)phenyl)-7-((S)-2-hydroxy-4-methoxy-3-oxobutan-2-yl)-7-methyl-3,4,6,7,8,8a,9,10-octahydrophenanthren-2(5H)-one | C28H37NO4 | 详情 | 详情 |
Extended Information