3-((1R)-1-((tert-butoxycarbonyl)amino)-2-((1R,5R)-3-cyano-2-azabicyclo[3.1.0]hexan-2-yl)-2-oxoethyl)adamantan-1-yl 2,2,2-trifluoroacetate -Drug Synthesis Database

【结构式】

【分子编号】67426

【品名】3-((1R)-1-((tert-butoxycarbonyl)amino)-2-((1R,5R)-3-cyano-2-azabicyclo[3.1.0]hexan-2-yl)-2-oxoethyl)adamantan-1-yl 2,2,2-trifluoroacetate

【CA登记号】　

【分子式】C₂₅H₃₂F₃N₃O₅

【分子量】511.542

【元素组成】C 58.70% H 6.30% F 11.14% N 8.21% O 15.64%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号：(IV)

【1】 Hnanson RL, Goldberg SL, Brzozowski DB, et al. 2007. Preparation of an amino acid intermediate for the dipeptidyl peptidase IV inhibitor, saxagliptin, using a modified phenylalanine dehydrogenase. Adv Synth Catal, 349: 1369～1378.
【2】 Sharma PN, Galvin GM, Boettger SD, et al.2006. Ammonolysis process for the preparation of intermediates for DPP IV inhibitors. US 2006/0035954 A1.
【3】 Vu TC, Brzozowski DB, Fox R, et al.2004. Methods and compounds producing dipeptidyl peptidase IV inhibitors and intermediates thereof. WO 2004/052850 A2.

中间体序号	中间体编号	品名	分子式	供应商	用于合成
(I)	65680	N-Boc-(S)-(3-hydroxyadamantyl)glycine	C₁₇H₂₈NO₅	详情	详情
(II)	67425	(1S,3S,5S)-2-Azabicyclo[3.1.0]hexane-3-carboxamide methanesulfonate	C₆H₁₀N₂O.CH₄O₃S	详情	详情
(III)	65683		C₂₃H₃₆N₃O₅	详情	详情
(IV)	67426	3-((1R)-1-((tert-butoxycarbonyl)amino)-2-((1R,5R)-3-cyano-2-azabicyclo[3.1.0]hexan-2-yl)-2-oxoethyl)adamantan-1-yl 2,2,2-trifluoroacetate	C₂₅H₃₂F₃N₃O₅	详情	详情
(V)	65686		C₂₂H₃₄N₃O₅	详情	详情

Extended Information