(1S,3S,5S)-2-Azabicyclo[3.1.0]hexane-3-carboxamide methanesulfonate -Drug Synthesis Database

【结构式】

【分子编号】67425

【品名】(1S,3S,5S)-2-Azabicyclo[3.1.0]hexane-3-carboxamide methanesulfonate

【CA登记号】　

【分子式】C₆H₁₀N₂O.CH₄O₃S

【分子量】222.265

【元素组成】C 37.83% H 6.35% N 12.60% O 28.79% S 14.43%

与该中间体有关的原料药合成路线共 2 条

该中间体在本合成路线中的序号：(II)

【1】 Hnanson RL, Goldberg SL, Brzozowski DB, et al. 2007. Preparation of an amino acid intermediate for the dipeptidyl peptidase IV inhibitor, saxagliptin, using a modified phenylalanine dehydrogenase. Adv Synth Catal, 349: 1369～1378.
【2】 Sharma PN, Galvin GM, Boettger SD, et al.2006. Ammonolysis process for the preparation of intermediates for DPP IV inhibitors. US 2006/0035954 A1.
【3】 Vu TC, Brzozowski DB, Fox R, et al.2004. Methods and compounds producing dipeptidyl peptidase IV inhibitors and intermediates thereof. WO 2004/052850 A2.

中间体序号	中间体编号	品名	分子式	供应商	用于合成
(I)	65680	N-Boc-(S)-(3-hydroxyadamantyl)glycine	C₁₇H₂₈NO₅	详情	详情
(II)	67425	(1S,3S,5S)-2-Azabicyclo[3.1.0]hexane-3-carboxamide methanesulfonate	C₆H₁₀N₂O.CH₄O₃S	详情	详情
(III)	65683		C₂₃H₃₆N₃O₅	详情	详情
(IV)	67426	3-((1R)-1-((tert-butoxycarbonyl)amino)-2-((1R,5R)-3-cyano-2-azabicyclo[3.1.0]hexan-2-yl)-2-oxoethyl)adamantan-1-yl 2,2,2-trifluoroacetate	C₂₅H₃₂F₃N₃O₅	详情	详情
(V)	65686		C₂₂H₃₄N₃O₅	详情	详情

该中间体在本合成路线中的序号：（VIII）

中间体序号	中间体编号	品名	CAS号	分子式	供应商	用于合成
(VI)	65708	(2S)-2-(Aminocarbonyl)-2,3-dihydro-1H-pyrrole-1-carboxylic acid 1,1-dimethylethyl ester	709031-38-9	C₁₀H₁₆N₂O₃	详情	详情
（VIII）	67425	(1S,3S,5S)-2-Azabicyclo[3.1.0]hexane-3-carboxamide methanesulfonate		C₆H₁₀N₂O.CH₄O₃S	详情	详情
(I)	32406	(2S)-5-oxo-2-pyrrolidinecarboxylic acid	98-79-3	C₅H₇NO₃	详情	详情
(II)	65704	Ethyl L-pyroglutamate; Ethyl 5-oxo-L-prolinate; Ethyl (S)-(+)-2-pyrrolidone-5-carboxylate; 5-Oxo-proline ethyl ester; L(+)-Pyroglutamic acid ethyl ester	7149-65-7	C₇H₁₁NO₃	详情	详情
(III)	43914	1-(tert-butyl) 2-ethyl (2S)-5-oxo-1,2-pyrrolidinedicarboxylate	144978-35-8	C₁₂H₁₉NO₅	详情	详情
(IV)	65706	(S)-1-Boc-2,3-dihydro-2-pyrrolecarboxylic acid ethyl ester; (S)-1-tert-Butyl 2-ethyl 2,3-dihydro-1H-pyrrole-1,2-dicarboxylate; Ethyl N-Boc-L-proline-4-ene	178172-26-4	C₁₂H₁₉NO₄	详情	详情
(V)	65707	(S)-1-(tert-Butoxycarbonyl)-2,5-dihydro-1H-pyrrole-2-carboxylic acid; Boc-3,4-Dehydro-Pro-OH	51154-06-4	C₁₀H₁₅NO₄	详情	详情

Extended Information