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【结 构 式】 
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【分子编号】67372 【品名】benzyl (2-cyanopropan-2-yl)carbamate 【CA登记号】100134-82-5 |
【 分 子 式 】C12H14N2O2 【 分 子 量 】218.25544 【元素组成】C 66.04% H 6.47% N 12.84% O 14.66% |
与该中间体有关的原料药合成路线共 1 条
合成路线1
该中间体在本合成路线中的序号：(III)
| 【1】 Belyk, K.M., Morrison, H.G., Jones, P., Summa, V. (Merck & Co., Inc.; Istituto di Ricerche di Biologia Molecolare P. Angeletti S.p.A.). Potassium salt of an HIV integrase inhibitor. US 2006122205, WO 2006060712, WO 2006060730. |
| 【2】 Drugs of the Future 2007, 32(2): 118-122 |
| 【1】 Belyk KM, Morrison HG, Jones P, et al. 2006. Potassium salt of an HIV integrase inhibitor. US 2006/0122205 A1 (Merck & Co Inc). |
| 【2】 Kassahum K. 2006. Use of atazanavir for improving the pharmacokinetics of drugs metabolized by UGT1A1. WO 2006/060731 A2 (Merck & Co Inc). |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 18029 | Acetone cyanohydrin; 2-Hydroxy-2-methylpropanenitrile; 2-Hydroxy-2-methylpropionitrile; 2-Hydroxyisobutyronitrile; 2-Methyllactonitrile; alpha-Hydroxyisobutyronitrile | 75-86-5 | C4H7NO | 详情 | 详情 |
| (II) | 18745 | 2-amino-2-methylpropanenitrile | 19355-69-2 | C4H8N2 | 详情 | 详情 |
| (III) | 67372 | benzyl (2-cyanopropan-2-yl)carbamate | 100134-82-5 | C12H14N2O2 | 详情 | 详情 |
| (IV) | 67373 | (Z)-benzyl (1-amino-1-(hydroxyimino)-2-methylpropan-2-yl)carbamate | C12H17N3O3 | 详情 | 详情 | |
| (V) | 67374 | dimethyl 2-((Z)-(1-amino-2-(((benzyloxy)carbonyl)amino)-2-methylpropylidene)amino)maleate | C18H23N3O6 | 详情 | 详情 | |
| (VI) | 67375 | methyl 2-(2-(((benzyloxy)carbonyl)amino)propan-2-yl)-5-hydroxy-6-oxo-1,6-dihydropyrimidine-4-carboxylate | C17H19N3O6 | 详情 | 详情 | |
| (VII) | 67376 | methyl 2-(2-(((benzyloxy)carbonyl)amino)propan-2-yl)-5-hydroxy-1-methyl-6-oxo-1,6-dihydropyrimidine-4-carboxylate | 888504-27-6 | C18H21N3O6 | 详情 | 详情 |
| (VIII) | 67377 | benzyl (2-(4-((4-fluorobenzyl)carbamoyl)-5-hydroxy-1-methyl-6-oxo-1,6-dihydropyrimidin-2-yl)propan-2-yl)carbamate | 518048-02-7 | C24H25FN4O5 | 详情 | 详情 |
| (IX) | 67378 | 2-(2-aminopropan-2-yl)-N-(4-fluorobenzyl)-5-hydroxy-1-methyl-6-oxo-1,6-dihydropyrimidine-4-carboxamide | 518048-03-8 | C16H19FN4O3 | 详情 | 详情 |
| (X) | 67379 | 5-methyl-1,3,4-oxadiazole-2-carbonyl chloride | C4H3ClN2O2 | 详情 | 详情 |
Extended Information