tert-butyl(((S)-1-((R)-6-fluoro-2H-chromen-2-yl)allyl)oxy)dimethylsilane -Drug Synthesis Database

【结构式】

【分子编号】67325

【品名】tert-butyl(((S)-1-((R)-6-fluoro-2H-chromen-2-yl)allyl)oxy)dimethylsilane

【CA登记号】　

【分子式】C₁₈H₂₅FO₂Si

【分子量】320.479

【元素组成】C 67.46% H 7.86% F 5.93% O 9.98% Si 8.76%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号：(XVII)

参考文献中间体

合成目标

【1】陈鹏，吕春雷。2005.DL-奈比洛尔及盐酸盐的制备方法。发明专利申请公开说明书，1683355.
【2】 Chandrasekhar S,Reddy MV.2000.Enantioselective total synthesis of the antihypertensive agent (S,R,R,R)-nebivolol. Tetrahedron, 56: 6339～6344.
【3】 Charles W,Johannes MS, Visser GS, et al. 1998. Zr-catalyzed kinetic resolution of allylic ethers and mo-catalyzed chromene formation in synthesis. Enantioselective total synthesis of the antihypertensive agent (S,R,R,R)-nebivolol. J Am Chem Soc,120: 8340～8347.

中间体序号	中间体编号	品名	CAS号	分子式	供应商	用于合成
(IX）	40855	4-fluoro-2-[(E)-5-hydroxy-3-pentenyl]phenol		C₁₁H₁₃FO₂	详情	详情
(I)	19639	4-fluorophenol	371-41-5	C₆H₅FO	详情	详情
(II)	40848	1-(allyloxy)-4-fluorobenzene; allyl 4-fluorophenyl ether		C₉H₉FO	详情	详情
(III)	40849	2-allyl-4-fluorophenol		C₉H₉FO	详情	详情
(IV)	40850	(2-allyl-4-fluorophenoxy)(tert-butyl)dimethylsilane; 2-allyl-4-fluorophenyl tert-butyl(dimethyl)silyl ether		C₁₅H₂₃FOSi	详情	详情
(V)	40851	3-(2-[[tert-butyl(dimethyl)silyl]oxy]-5-fluorophenyl)-1-propanol		C₁₅H₂₅FO₂Si	详情	详情
(VI)	40852	3-(2-[[tert-butyl(dimethyl)silyl]oxy]-5-fluorophenyl)propanal		C₁₅H₂₃FO₂Si	详情	详情
(VII)	40853	ethyl (E)-5-(2-[[tert-butyl(dimethyl)silyl]oxy]-5-fluorophenyl)-2-pentenoate		C₁₉H₂₉FO₃Si	详情	详情
(VIII)	40854	(E)-5-(2-[[tert-butyl(dimethyl)silyl]oxy]-5-fluorophenyl)-2-penten-1-ol		C₁₇H₂₇FO₂Si	详情	详情
(X)	40856	(1R)-1-[(2S)-6-fluoro-3,4-dihydro-2H-chromen-2-yl]-1,2-ethanediol		C₁₁H₁₃FO₃	详情	详情
(XI)	40857	(2R)-2-[(2S)-6-fluoro-3,4-dihydro-2H-chromen-2-yl]-2-hydroxyethyl 4-methylbenzenesulfonate		C₁₈H₁₉FO₅S	详情	详情
(XII)	40858	(1R)-2-azido-1-[(2S)-6-fluoro-3,4-dihydro-2H-chromen-2-yl]-1-ethanol		C₁₁H₁₂FN₃O₂	详情	详情
(XIII)	40859	(1R)-2-amino-1-[(2S)-6-fluoro-3,4-dihydro-2H-chromen-2-yl]-1-ethanol		C₁₁H₁₄FNO₂	详情	详情
(XIV)	67322	(1R,7S)-8-oxabicyclo[5.1.0]octane		C₇H₁₂O	详情	详情
(XV)	67323	tert-butyl(((1S,2R)-2-(4-fluoro-2-((Z)-prop-1-en-1-yl)phenoxy)cyclohept-3-en-1-yl)oxy)dimethylsilane		C₂₂H₃₃FO₂Si	详情	详情
(XVI)	67324	tert-butyl(((S)-1-((R)-6-fluoro-2H-chromen-2-yl)hex-5-en-1-yl)oxy)dimethylsilane		C₂₁H₃₁FO₂Si	详情	详情
(XVII)	67325	tert-butyl(((S)-1-((R)-6-fluoro-2H-chromen-2-yl)allyl)oxy)dimethylsilane		C₁₈H₂₅FO₂Si	详情	详情
(XVIII)	67326	(R)-2-((tert-butyldimethylsilyl)oxy)-2-((S)-6-fluorochroman-2-yl)acetaldehyde		C₁₇H₂₅FO₃Si	详情	详情
(XIX)	67328	(R)-2-(((S)-2-((tert-butyldimethylsilyl)oxy)-2-((S)-6-fluorochroman-2-yl)ethyl)amino)-1-((R)-6-fluorochroman-2-yl)ethanol		C₂₈H₃₉F₂NO₄Si	详情	详情
(XX)	67327	(R)-2-(((S)-2-((tert-butyldimethylsilyl)oxy)-2-((S)-6-fluorochroman-2-yl)ethyl)amino)-1-((R)-6-fluorochroman-2-yl)ethanol hydrochloride		C₂₈H₃₉F₂NO₄Si.HCl	详情	详情

Extended Information