【结 构 式】 |
【分子编号】67324 【品名】tert-butyl(((S)-1-((R)-6-fluoro-2H-chromen-2-yl)hex-5-en-1-yl)oxy)dimethylsilane 【CA登记号】 |
【 分 子 式 】C21H31FO2Si 【 分 子 量 】362.56 【元素组成】C 69.57% H 8.62% F 5.24% O 8.83% Si 7.75% |
与该中间体有关的原料药合成路线共 1 条
合成路线1
该中间体在本合成路线中的序号:(XVI)
【1】 陈鹏,吕春雷。2005.DL-奈比洛尔及盐酸盐的制备方法。发明专利申请公开说明书,1683355. |
【2】 Chandrasekhar S,Reddy MV.2000.Enantioselective total synthesis of the antihypertensive agent (S,R,R,R)-nebivolol. Tetrahedron, 56: 6339~6344. |
【3】 Charles W,Johannes MS, Visser GS, et al. 1998. Zr-catalyzed kinetic resolution of allylic ethers and mo-catalyzed chromene formation in synthesis. Enantioselective total synthesis of the antihypertensive agent (S,R,R,R)-nebivolol. J Am Chem Soc,120: 8340~8347. |
中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
---|---|---|---|---|---|---|
(IX) | 40855 | 4-fluoro-2-[(E)-5-hydroxy-3-pentenyl]phenol | C11H13FO2 | 详情 | 详情 | |
(I) | 19639 | 4-fluorophenol | 371-41-5 | C6H5FO | 详情 | 详情 |
(II) | 40848 | 1-(allyloxy)-4-fluorobenzene; allyl 4-fluorophenyl ether | C9H9FO | 详情 | 详情 | |
(III) | 40849 | 2-allyl-4-fluorophenol | C9H9FO | 详情 | 详情 | |
(IV) | 40850 | (2-allyl-4-fluorophenoxy)(tert-butyl)dimethylsilane; 2-allyl-4-fluorophenyl tert-butyl(dimethyl)silyl ether | C15H23FOSi | 详情 | 详情 | |
(V) | 40851 | 3-(2-[[tert-butyl(dimethyl)silyl]oxy]-5-fluorophenyl)-1-propanol | C15H25FO2Si | 详情 | 详情 | |
(VI) | 40852 | 3-(2-[[tert-butyl(dimethyl)silyl]oxy]-5-fluorophenyl)propanal | C15H23FO2Si | 详情 | 详情 | |
(VII) | 40853 | ethyl (E)-5-(2-[[tert-butyl(dimethyl)silyl]oxy]-5-fluorophenyl)-2-pentenoate | C19H29FO3Si | 详情 | 详情 | |
(VIII) | 40854 | (E)-5-(2-[[tert-butyl(dimethyl)silyl]oxy]-5-fluorophenyl)-2-penten-1-ol | C17H27FO2Si | 详情 | 详情 | |
(X) | 40856 | (1R)-1-[(2S)-6-fluoro-3,4-dihydro-2H-chromen-2-yl]-1,2-ethanediol | C11H13FO3 | 详情 | 详情 | |
(XI) | 40857 | (2R)-2-[(2S)-6-fluoro-3,4-dihydro-2H-chromen-2-yl]-2-hydroxyethyl 4-methylbenzenesulfonate | C18H19FO5S | 详情 | 详情 | |
(XII) | 40858 | (1R)-2-azido-1-[(2S)-6-fluoro-3,4-dihydro-2H-chromen-2-yl]-1-ethanol | C11H12FN3O2 | 详情 | 详情 | |
(XIII) | 40859 | (1R)-2-amino-1-[(2S)-6-fluoro-3,4-dihydro-2H-chromen-2-yl]-1-ethanol | C11H14FNO2 | 详情 | 详情 | |
(XIV) | 67322 | (1R,7S)-8-oxabicyclo[5.1.0]octane | C7H12O | 详情 | 详情 | |
(XV) | 67323 | tert-butyl(((1S,2R)-2-(4-fluoro-2-((Z)-prop-1-en-1-yl)phenoxy)cyclohept-3-en-1-yl)oxy)dimethylsilane | C22H33FO2Si | 详情 | 详情 | |
(XVI) | 67324 | tert-butyl(((S)-1-((R)-6-fluoro-2H-chromen-2-yl)hex-5-en-1-yl)oxy)dimethylsilane | C21H31FO2Si | 详情 | 详情 | |
(XVII) | 67325 | tert-butyl(((S)-1-((R)-6-fluoro-2H-chromen-2-yl)allyl)oxy)dimethylsilane | C18H25FO2Si | 详情 | 详情 | |
(XVIII) | 67326 | (R)-2-((tert-butyldimethylsilyl)oxy)-2-((S)-6-fluorochroman-2-yl)acetaldehyde | C17H25FO3Si | 详情 | 详情 | |
(XIX) | 67328 | (R)-2-(((S)-2-((tert-butyldimethylsilyl)oxy)-2-((S)-6-fluorochroman-2-yl)ethyl)amino)-1-((R)-6-fluorochroman-2-yl)ethanol | C28H39F2NO4Si | 详情 | 详情 | |
(XX) | 67327 | (R)-2-(((S)-2-((tert-butyldimethylsilyl)oxy)-2-((S)-6-fluorochroman-2-yl)ethyl)amino)-1-((R)-6-fluorochroman-2-yl)ethanol hydrochloride | C28H39F2NO4Si.HCl | 详情 | 详情 |
Extended Information