• English
  • 简体中文
Login Register
Current Location: Home > Feedback Help Print

【结 构 式】

【分子编号】67324

【品名】tert-butyl(((S)-1-((R)-6-fluoro-2H-chromen-2-yl)hex-5-en-1-yl)oxy)dimethylsilane

【CA登记号】 

【 分 子 式 】C21H31FO2Si

【 分 子 量 】362.56

【元素组成】C 69.57% H 8.62% F 5.24% O 8.83% Si 7.75%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号:(XVI)

 

1 陈鹏,吕春雷。2005.DL-奈比洛尔及盐酸盐的制备方法。发明专利申请公开说明书,1683355.
2 Chandrasekhar S,Reddy MV.2000.Enantioselective total synthesis of the antihypertensive agent (S,R,R,R)-nebivolol. Tetrahedron, 56: 6339~6344.
3 Charles W,Johannes MS, Visser GS, et al. 1998. Zr-catalyzed kinetic resolution of allylic ethers and mo-catalyzed chromene formation in synthesis. Enantioselective total synthesis of the antihypertensive agent (S,R,R,R)-nebivolol. J Am Chem Soc,120: 8340~8347.
中间体序号 中间体编号 品名 CAS号 分子式 供应商 用于合成
(IX) 40855 4-fluoro-2-[(E)-5-hydroxy-3-pentenyl]phenol C11H13FO2 详情 详情
(I) 19639 4-fluorophenol 371-41-5 C6H5FO 详情 详情
(II) 40848 1-(allyloxy)-4-fluorobenzene; allyl 4-fluorophenyl ether C9H9FO 详情 详情
(III) 40849 2-allyl-4-fluorophenol C9H9FO 详情 详情
(IV) 40850 (2-allyl-4-fluorophenoxy)(tert-butyl)dimethylsilane; 2-allyl-4-fluorophenyl tert-butyl(dimethyl)silyl ether C15H23FOSi 详情 详情
(V) 40851 3-(2-[[tert-butyl(dimethyl)silyl]oxy]-5-fluorophenyl)-1-propanol C15H25FO2Si 详情 详情
(VI) 40852 3-(2-[[tert-butyl(dimethyl)silyl]oxy]-5-fluorophenyl)propanal C15H23FO2Si 详情 详情
(VII) 40853 ethyl (E)-5-(2-[[tert-butyl(dimethyl)silyl]oxy]-5-fluorophenyl)-2-pentenoate C19H29FO3Si 详情 详情
(VIII) 40854 (E)-5-(2-[[tert-butyl(dimethyl)silyl]oxy]-5-fluorophenyl)-2-penten-1-ol C17H27FO2Si 详情 详情
(X) 40856 (1R)-1-[(2S)-6-fluoro-3,4-dihydro-2H-chromen-2-yl]-1,2-ethanediol C11H13FO3 详情 详情
(XI) 40857 (2R)-2-[(2S)-6-fluoro-3,4-dihydro-2H-chromen-2-yl]-2-hydroxyethyl 4-methylbenzenesulfonate C18H19FO5S 详情 详情
(XII) 40858 (1R)-2-azido-1-[(2S)-6-fluoro-3,4-dihydro-2H-chromen-2-yl]-1-ethanol C11H12FN3O2 详情 详情
(XIII) 40859 (1R)-2-amino-1-[(2S)-6-fluoro-3,4-dihydro-2H-chromen-2-yl]-1-ethanol C11H14FNO2 详情 详情
(XIV) 67322 (1R,7S)-8-oxabicyclo[5.1.0]octane   C7H12O 详情 详情
(XV) 67323 tert-butyl(((1S,2R)-2-(4-fluoro-2-((Z)-prop-1-en-1-yl)phenoxy)cyclohept-3-en-1-yl)oxy)dimethylsilane   C22H33FO2Si 详情 详情
(XVI) 67324 tert-butyl(((S)-1-((R)-6-fluoro-2H-chromen-2-yl)hex-5-en-1-yl)oxy)dimethylsilane   C21H31FO2Si 详情 详情
(XVII) 67325 tert-butyl(((S)-1-((R)-6-fluoro-2H-chromen-2-yl)allyl)oxy)dimethylsilane   C18H25FO2Si 详情 详情
(XVIII) 67326 (R)-2-((tert-butyldimethylsilyl)oxy)-2-((S)-6-fluorochroman-2-yl)acetaldehyde   C17H25FO3Si 详情 详情
(XIX) 67328 (R)-2-(((S)-2-((tert-butyldimethylsilyl)oxy)-2-((S)-6-fluorochroman-2-yl)ethyl)amino)-1-((R)-6-fluorochroman-2-yl)ethanol   C28H39F2NO4Si 详情 详情
(XX) 67327 (R)-2-(((S)-2-((tert-butyldimethylsilyl)oxy)-2-((S)-6-fluorochroman-2-yl)ethyl)amino)-1-((R)-6-fluorochroman-2-yl)ethanol hydrochloride   C28H39F2NO4Si.HCl 详情 详情
Extended Information