(1R,2S)-2-((1,3-dioxoisoindolin-2-yl)methyl)-N,N-diethyl-1-phenylcyclopropanecarboxamide -Drug Synthesis Database

【结构式】

【分子编号】67288

【品名】(1R,2S)-2-((1,3-dioxoisoindolin-2-yl)methyl)-N,N-diethyl-1-phenylcyclopropanecarboxamide

【CA登记号】　

【分子式】C₂₃H₂₄N₂O₃

【分子量】376.45524

【元素组成】C 73.38% H 6.43% N 7.44% O 12.75%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号：(VII)

【1】王晓琴，徐鹏，顾君琳，等.2004.盐酸米那普仑右旋异构体的合成。中国医药工业杂志，35（5）：259～260.
【2】 Bonnaud B, Cousse H, Mouzin G, et al. 1987. 1-Aryl-2-(aminomethyl) cyclopropanecarboxylic acid derivatives. A new series of potential antidepressants. J Med Chem, 30: 318～325.

中间体序号	中间体编号	品名	CAS号	分子式	供应商	用于合成
(I)	17046	Phenylacetonitrile; 2-phenylacetonitrile; Benzyl cyanide	140-29-4	C₈H₇N	详情	详情
(I)	17046	Phenylacetonitrile; 2-phenylacetonitrile; Benzyl cyanide	140-29-4	C₈H₇N	详情	详情
(II)	38067	(2R)-2-(Chloromethyl)oxirane; (R)-Epichlorohydrin	51594-55-9	C₃H₅ClO	详情	详情
(II)	61470	(1S,5R)-1-phenyl-3-oxabicyclo[3.1.0]hexan-2-one	63106-93-4	C₁₁H₁₀O₂	详情	详情
(III)	67285	(1R,2S)-2-(hydroxymethyl)-1-phenylcyclopropanecarbonitrile		C₁₁H₁₁NO	详情	详情
(III)	67290	(1S,2R)-N,N-diethyl-2-(hydroxymethyl)-1-phenylcyclopropanecarboxamide		C₁₅H₂₁NO₂	详情	详情
(IV)	61470	(1S,5R)-1-phenyl-3-oxabicyclo[3.1.0]hexan-2-one	63106-93-4	C₁₁H₁₀O₂	详情	详情
(IV)	67291	(1R,2S)-2-(azidomethyl)-N,N-diethyl-1-phenylcyclopropanecarboxamide		C₁₅H₂₀N₄O	详情	详情
(V)	67287	(1S,2R)-2-((1,3-dioxoisoindolin-2-yl)methyl)-1-phenylcyclopropanecarboxylic acid		C₁₉H₁₅NO₄	详情	详情
(VI)	67286	(1R,2S)-2-((1,3-dioxoisoindolin-2-yl)methyl)-1-phenylcyclopropanecarbonyl chloride		C₁₉H₁₄ClNO₃	详情	详情
(VII)	67288	(1R,2S)-2-((1,3-dioxoisoindolin-2-yl)methyl)-N,N-diethyl-1-phenylcyclopropanecarboxamide		C₂₃H₂₄N₂O₃	详情	详情
(VIII)	67289	(1R,2S)-2-(aminomethyl)-N,N-diethyl-1-phenylcyclopropanecarboxamide	92623-85-3	C₁₅H₂₂N₂O	详情	详情

Extended Information