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【结 构 式】 
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【分子编号】67287 【品名】(1S,2R)-2-((1,3-dioxoisoindolin-2-yl)methyl)-1-phenylcyclopropanecarboxylic acid 【CA登记号】 |
【 分 子 式 】C19H15NO4 【 分 子 量 】321.33244 【元素组成】C 71.02% H 4.71% N 4.36% O 19.92% |
与该中间体有关的原料药合成路线共 1 条
合成路线1
该中间体在本合成路线中的序号：(V)
| 【1】 王晓琴，徐鹏，顾君琳，等.2004.盐酸米那普仑右旋异构体的合成。中国医药工业杂志，35（5）：259～260. |
| 【2】 Bonnaud B, Cousse H, Mouzin G, et al. 1987. 1-Aryl-2-(aminomethyl) cyclopropanecarboxylic acid derivatives. A new series of potential antidepressants. J Med Chem, 30: 318～325. |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 17046 | Phenylacetonitrile; 2-phenylacetonitrile; Benzyl cyanide | 140-29-4 | C8H7N | 详情 | 详情 |
| (I) | 17046 | Phenylacetonitrile; 2-phenylacetonitrile; Benzyl cyanide | 140-29-4 | C8H7N | 详情 | 详情 |
| (II) | 38067 | (2R)-2-(Chloromethyl)oxirane; (R)-Epichlorohydrin | 51594-55-9 | C3H5ClO | 详情 | 详情 |
| (II) | 61470 | (1S,5R)-1-phenyl-3-oxabicyclo[3.1.0]hexan-2-one | 63106-93-4 | C11H10O2 | 详情 | 详情 |
| (III) | 67285 | (1R,2S)-2-(hydroxymethyl)-1-phenylcyclopropanecarbonitrile | C11H11NO | 详情 | 详情 | |
| (III) | 67290 | (1S,2R)-N,N-diethyl-2-(hydroxymethyl)-1-phenylcyclopropanecarboxamide | C15H21NO2 | 详情 | 详情 | |
| (IV) | 61470 | (1S,5R)-1-phenyl-3-oxabicyclo[3.1.0]hexan-2-one | 63106-93-4 | C11H10O2 | 详情 | 详情 |
| (IV) | 67291 | (1R,2S)-2-(azidomethyl)-N,N-diethyl-1-phenylcyclopropanecarboxamide | C15H20N4O | 详情 | 详情 | |
| (V) | 67287 | (1S,2R)-2-((1,3-dioxoisoindolin-2-yl)methyl)-1-phenylcyclopropanecarboxylic acid | C19H15NO4 | 详情 | 详情 | |
| (VI) | 67286 | (1R,2S)-2-((1,3-dioxoisoindolin-2-yl)methyl)-1-phenylcyclopropanecarbonyl chloride | C19H14ClNO3 | 详情 | 详情 | |
| (VII) | 67288 | (1R,2S)-2-((1,3-dioxoisoindolin-2-yl)methyl)-N,N-diethyl-1-phenylcyclopropanecarboxamide | C23H24N2O3 | 详情 | 详情 | |
| (VIII) | 67289 | (1R,2S)-2-(aminomethyl)-N,N-diethyl-1-phenylcyclopropanecarboxamide | 92623-85-3 | C15H22N2O | 详情 | 详情 |
Extended Information