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【结 构 式】 
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【分子编号】67116 【品名】3'-hydroxy-4'-nitro-[1,1'-biphenyl]-4-carboxylic acid 【CA登记号】 |
【 分 子 式 】C13H9NO5 【 分 子 量 】259.2182 【元素组成】C 60.24% H 3.5% N 5.4% O 30.86% |
与该中间体有关的原料药合成路线共 1 条
合成路线1
该中间体在本合成路线中的序号：(III)
| 【1】 Duffy KJ, Erickson-Miller CL, Eppley DF, et al.2001. Thrombopoietin mimetics. WO 2001089457 |
| 【2】 Moore S. 2003. Preparation of (pyrazolidenehydrazino) [1,1'-biphenyl]-3-carboxylates as TPO receptor agonists for enhancing platelet prodn. WO 2003098992. |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 20704 | 3-bromophenol | 591-20-8 | C6H5BrO | 详情 | 详情 |
| (II) | 67115 | 2-Nitro-5-bromophenol;3-Bromo-6-nitrophenol;5-Bromo-2-nitrophenol | 27684-84-0 | C6H4BrNO3 | 详情 | 详情 |
| (III) | 67116 | 3'-hydroxy-4'-nitro-[1,1'-biphenyl]-4-carboxylic acid | C13H9NO5 | 详情 | 详情 | |
| (IV) | 67117 | 4'-amino-3'-hydroxy-[1,1'-biphenyl]-4-carboxylic acid | C13H11NO3 | 详情 | 详情 | |
| (V) | 67118 | 1-(3,4-dimethylphenyl)-3-methyl-1H-pyrazol-5(4H)-one | 18048-64-1 | C12H14N2O | 详情 | 详情 |
| (VI) | 67119 | 3'-(2-(1-(3,4-dimethylphenyl)-3-methyl-5-oxo-1H-pyrazol-4(5H)-ylidene)hydrazinyl)-2'-hydroxy-[1,1'-biphenyl]-3-carboxylic acid | 496775-61-2 | C25H22N4O4 | 详情 | 详情 |
| (VII) | 32841 | 4-(dihydroxyboryl)benzoic acid；4-Boronobenzoic acid；4-carboxyphenylboronic acid;4-(Dihydroxyboryl)benzoic acid | 14047-29-1 | C7H7BO4 | 详情 | 详情 |
Extended Information