Eltrombopag, SB-497115-GR (as olamine), SB-497115, Promacta, -Drug Synthesis Database

【结构式】

【药物名称】Eltrombopag, SB-497115-GR (as olamine), SB-497115, Promacta

【化学名称】3'-[2(Z)-[1-(3,4-Dimethylphenyl)-3-methyl-5-oxo-4,5-dihydro-1H-pyrazol-4-ylidene]hydrazino]-2'-hydroxybiphenyl-3-carboxylic acid

【CA登记号】496775-61-2, 376591-99-0 (as undefined isomer), 443130-00-5 (as undefined isomer hydrate), 496775-62-3 (as olamine)

【分子式】C₂₅H₂₂N₄O₄

【分子量】442.4667

【开发单位】GlaxoSmithKline (US); developed in collaboration with Ligand Pharmaceuticals, Inc. (US).

【药理作用】Antithrombocytopenic, Thrombopoietin receptor agonist

【1】 Duffy KJ, Erickson-Miller CL, Eppley DF, et al.2001. Thrombopoietin mimetics. WO 2001089457
【2】 Moore S. 2003. Preparation of (pyrazolidenehydrazino) [1,1'-biphenyl]-3-carboxylates as TPO receptor agonists for enhancing platelet prodn. WO 2003098992.

中间体序号	中间体编号	品名	CAS号	分子式	供应商	用于合成
(I)	20704	3-bromophenol	591-20-8	C₆H₅BrO	详情	详情
(II)	67115	2-Nitro-5-bromophenol;3-Bromo-6-nitrophenol;5-Bromo-2-nitrophenol	27684-84-0	C₆H₄BrNO₃	详情	详情
(III)	67116	3'-hydroxy-4'-nitro-[1,1'-biphenyl]-4-carboxylic acid		C₁₃H₉NO₅	详情	详情
(IV)	67117	4'-amino-3'-hydroxy-[1,1'-biphenyl]-4-carboxylic acid		C₁₃H₁₁NO₃	详情	详情
(V)	67118	1-(3,4-dimethylphenyl)-3-methyl-1H-pyrazol-5(4H)-one	18048-64-1	C₁₂H₁₄N₂O	详情	详情
(VI)	67119	3'-(2-(1-(3,4-dimethylphenyl)-3-methyl-5-oxo-1H-pyrazol-4(5H)-ylidene)hydrazinyl)-2'-hydroxy-[1,1'-biphenyl]-3-carboxylic acid	496775-61-2	C₂₅H₂₂N₄O₄	详情	详情
(VII)	32841	4-(dihydroxyboryl)benzoic acid；4-Boronobenzoic acid；4-carboxyphenylboronic acid;4-(Dihydroxyboryl)benzoic acid	14047-29-1	C₇H₇BO₄	详情	详情

【1】 Duffy KJ, Erickson-Miller CL, Eppley DF, et al.2001. Thrombopoietin mimetics. WO 2001089457
【2】 Moore S. 2003. Preparation of (pyrazolidenehydrazino) [1,1'-biphenyl]-3-carboxylates as TPO receptor agonists for enhancing platelet prodn. WO 2003098992.

中间体序号	中间体编号	品名	CAS号	分子式	供应商	用于合成
(I)	67120	2-Bromophenol;o-bromophenol	95-56-7	C₆H₅BrO	详情	详情
(II)	67121	2-bromo-6-nitrophenol	13073-25-1	C₆H₄BrNO₃	详情	详情
(III)	67122	1-bromo-2-methoxy-3-nitrobenzene；1-bromo-2-methoxy-3-nitrobenzene	98775-19-0	C₇H₆BrNO₃	详情	详情
(IV)	67124	2'-methoxy-3'-nitro-[1,1'-biphenyl]-3-carboxylic acid		C₁₄H₁₁NO₅	详情	详情
(V)	67125	2'-hydroxy-3'-nitro-[1,1'-biphenyl]-3-carboxylic acid		C₁₃H₉NO₅	详情	详情
(VI)	67126	3'-amino-2'-hydroxy-[1,1'-biphenyl]-3-carboxylic acid	376592-93-7	C₁₃H₁₁NO₃	详情	详情
(VII)	67118	1-(3,4-dimethylphenyl)-3-methyl-1H-pyrazol-5(4H)-one	18048-64-1	C₁₂H₁₄N₂O	详情	详情
(VIII)	67119	3'-(2-(1-(3,4-dimethylphenyl)-3-methyl-5-oxo-1H-pyrazol-4(5H)-ylidene)hydrazinyl)-2'-hydroxy-[1,1'-biphenyl]-3-carboxylic acid	496775-61-2	C₂₅H₂₂N₄O₄	详情	详情
(IX)	67123	3-boronobenzoic acid		C₇H₇BO₄	详情	详情

Extended Information