(2R,4R)-4-nitrobenzyl 4-(acetylthio)-2-((sulfamoylamino)methyl)pyrrolidine-1-carboxylate -Drug Synthesis Database

【结构式】

【分子编号】67080

【品名】(2R,4R)-4-nitrobenzyl 4-(acetylthio)-2-((sulfamoylamino)methyl)pyrrolidine-1-carboxylate

【CA登记号】　

【分子式】C₁₅H₂₀N₄O₇S₂

【分子量】432.479

【元素组成】C 41.66% H 4.66% N 12.95% O 25.90% S 14.83%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号：(II)

【1】 Nishino Y, Kobayashi M, Shinno T.2003.Practical large-scale synthesis of doripenem: a novel 1β-methylcarbapenem antibiotic. Orangic Process Research & Development, 7:846.

中间体序号	中间体编号	品名	CAS号	分子式	供应商	用于合成
(I)	67079	(2S,4S)-4-nitrobenzyl 4-(acetylthio)-2-(((tert-butoxycarbonyl)(sulfamoyl)amino)methyl)pyrrolidine-1-carboxylate	491878-06-9	C₂₀H₂₈N₄O₉S₂	详情	详情
(II)	67080	(2R,4R)-4-nitrobenzyl 4-(acetylthio)-2-((sulfamoylamino)methyl)pyrrolidine-1-carboxylate		C₁₅H₂₀N₄O₇S₂	详情	详情
(III)	16075	4-methoxybenzyl (4R,5R,6S)-3-[(diphenoxyphosphoryl)oxy]-6-[(1R)-1-hydroxyethyl]-4-methyl-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylate		C₃₀H₃₀NO₉P	详情	详情
(IV)	67081	nitro(phenyl)methyl 6-(1-hydroxyethyl)-4-methyl-3-((1-(((4-nitrobenzyl)oxy)carbonyl)-5-((sulfamoylamino)methyl)pyrrolidin-3-yl)thio)-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylate		C₃₀H₃₄N₆O₁₂S₂	详情	详情

Extended Information