【结 构 式】 |
【分子编号】67079 【品名】(2S,4S)-4-nitrobenzyl 4-(acetylthio)-2-(((tert-butoxycarbonyl)(sulfamoyl)amino)methyl)pyrrolidine-1-carboxylate 【CA登记号】491878-06-9 |
【 分 子 式 】C20H28N4O9S2 【 分 子 量 】532.596 【元素组成】C 45.10% H 5.30% N 10.52% O 27.04% S 12.04% |
与该中间体有关的原料药合成路线共 2 条
合成路线1
该中间体在本合成路线中的序号:(I)
【1】 Nishino Y, Kobayashi M, Shinno T.2003.Practical large-scale synthesis of doripenem: a novel 1β-methylcarbapenem antibiotic. Orangic Process Research & Development, 7:846. |
中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
---|---|---|---|---|---|---|
(I) | 67079 | (2S,4S)-4-nitrobenzyl 4-(acetylthio)-2-(((tert-butoxycarbonyl)(sulfamoyl)amino)methyl)pyrrolidine-1-carboxylate | 491878-06-9 | C20H28N4O9S2 | 详情 | 详情 |
(II) | 67080 | (2R,4R)-4-nitrobenzyl 4-(acetylthio)-2-((sulfamoylamino)methyl)pyrrolidine-1-carboxylate | C15H20N4O7S2 | 详情 | 详情 | |
(III) | 16075 | 4-methoxybenzyl (4R,5R,6S)-3-[(diphenoxyphosphoryl)oxy]-6-[(1R)-1-hydroxyethyl]-4-methyl-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylate | C30H30NO9P | 详情 | 详情 | |
(IV) | 67081 | nitro(phenyl)methyl 6-(1-hydroxyethyl)-4-methyl-3-((1-(((4-nitrobenzyl)oxy)carbonyl)-5-((sulfamoylamino)methyl)pyrrolidin-3-yl)thio)-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylate | C30H34N6O12S2 | 详情 | 详情 |
合成路线2
该中间体在本合成路线中的序号:(I)
【1】 Tewari N, George V, Mane AS, et al.2007. A process for the preparation of carbapenem compounds. WO 2007029084 A2. |
中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
---|---|---|---|---|---|---|
(II) | 67101 | 4-nitrobenzyl 2-(((tert-butoxycarbonyl)(sulfamoyl)amino)methyl)-4-mercaptopyrrolidine-1-carboxylate | C18H26N4O8S2 | 详情 | 详情 | |
(I) | 67079 | (2S,4S)-4-nitrobenzyl 4-(acetylthio)-2-(((tert-butoxycarbonyl)(sulfamoyl)amino)methyl)pyrrolidine-1-carboxylate | 491878-06-9 | C20H28N4O9S2 | 详情 | 详情 |
(III) | 16075 | 4-methoxybenzyl (4R,5R,6S)-3-[(diphenoxyphosphoryl)oxy]-6-[(1R)-1-hydroxyethyl]-4-methyl-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylate | C30H30NO9P | 详情 | 详情 | |
(IV) | 67090 | 4-nitrobenzyl 3-((5-(((tert-butoxycarbonyl)(sulfamoyl)amino)methyl)-1-(((4-nitrobenzyl)oxy)carbonyl)pyrrolidin-3-yl)thio)-6-(1-hydroxyethyl)-4-methyl-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylate | C35H42N6O14S2 | 详情 | 详情 |
Extended Information