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【结 构 式】 
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【分子编号】67018 【品名】benzyl (3-amino-2,2-dimethyl-3-oxopropyl)carbamate 【CA登记号】 |
【 分 子 式 】C13H18N2O3 【 分 子 量 】250.2976 【元素组成】C 62.38% H 7.25% N 11.19% O 19.18% |
与该中间体有关的原料药合成路线共 1 条
合成路线1
该中间体在本合成路线中的序号：(XXVI)
| 【1】 Dorg H, Zhang ZL, Huang JH, et al. 2005. Practical synthesisi of an orally active renin inhibitory aliskiren. Tetrahedron Lett, 46(37): 6337～6340 |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (XXV) | 67017 | 2-cyano-2-methylpropanamide | 7505-93-3 | C5H8N2O | 详情 | 详情 |
| (I) | 18455 | 3-hydroxy-4-methoxybenzaldehyde; Isovanillin | 621-59-0 | C8H8O3 | 详情 | 详情 |
| (II) | 67010 | 3-methoxypropyl methanesulfonate | C5H12O4S | 详情 | 详情 | |
| (III) | 61620 | 4-Methoxy-3-(3-methoxypropoxy)benzaldehyde | 172900-75-3 | C12H16O4 | 详情 | 详情 |
| (IV) | 28116 | [4-methoxy-3-(3-methoxypropoxy)phenyl]methanol | 172900-74-2 | C12H18O4 | 详情 | 详情 |
| (V) | 28117 | 3-[5-(bromomethyl)-2-methoxyphenoxy]propyl methyl ether | 172900-73-1 | C12H17BrO3 | 详情 | 详情 |
| (VI) | 28131 | (4S)-4-benzyl-3-(3-methylbutanoyl)-1,3-oxazolidin-2-one | C15H19NO3 | 详情 | 详情 | |
| (VII) | 28118 | (4S)-4-benzyl-3-[(2R)-2-[4-methoxy-3-(3-methoxypropoxy)benzyl]-3-methylbutanoyl]-1,3-oxazolidin-2-one | C27H35NO6 | 详情 | 详情 | |
| (VIII) | 28119 | (2R)-2-[4-methoxy-3-(3-methoxypropoxy)benzyl]-3-methylbutyric acid | C17H26O5 | 详情 | 详情 | |
| (IX) | 50573 | (2R)-2-[4-methoxy-3-(3-methoxypropoxy)benzyl]-3-methyl-1-butanol | C17H28O4 | 详情 | 详情 | |
| (X) | 28120 | 3-[5-[(2R)-2-(bromomethyl)-3-methylbutyl]-2-methoxyphenoxy]propyl methyl ether | 172900-69-5 | C17H27BrO3 | 详情 | 详情 |
| (XI) | 67009 | (S)-3,6-diethoxy-2-isopropyl-2,5-dihydropyrazine | 134870-62-5 | C11H20N2O2 | 详情 | 详情 |
| (XII) | 67011 | 3,6-diethoxy-2-isopropyl-5-(2-(4-methoxy-3-(3-methoxypropoxy)benzyl)-3-methylbutyl)-2,5-dihydropyrazine | C28H46N2O5 | 详情 | 详情 | |
| (XIII) | 67012 | ethyl 2-amino-4-(4-methoxy-3-(3-methoxypropoxy)benzyl)-5-methylhexanoate | C21H35NO5 | 详情 | 详情 | |
| (XIV) | 28122 | methyl (2S,4S)-2-[(tert-butoxycarbonyl)amino]-4-[4-methoxy-3-(3-methoxypropoxy)benzyl]-5-methylhexanoate | C25H41NO7 | 详情 | 详情 | |
| (XV) | 67013 | tert-butyl (1-hydroxy-4-(4-methoxy-3-(3-methoxypropoxy)benzyl)-5-methylhexan-2-yl)carbamate | C24H41NO6 | 详情 | 详情 | |
| (XVI) | 28123 | tert-butyl (1S,3S)-1-formyl-3-[4-methoxy-3-(3-methoxypropoxy)benzyl]-4-methylpentylcarbamate | C24H39NO6 | 详情 | 详情 | |
| (XVII) | 18710 | Benzyl alcohol; Phenylmethanol | 100-51-6 | C7H8O | 详情 | 详情 |
| (XVIII) | 14560 | Benzyl chloromethyl ether; 1-[(chloromethoxy)methyl]benzene | 3587-60-8 | C8H9ClO | 详情 | 详情 |
| (XIX) | 23285 | (4R)-4-benzyl-3-(3-methylbutanoyl)-1,3-oxazolidin-2-one | C15H19NO3 | 详情 | 详情 | |
| (XX) | 67014 | 4-benzyl-3-(2-((benzyloxy)methyl)-3-methylbutanoyl)oxazolidin-2-one | C23H27NO4 | 详情 | 详情 | |
| (XXI) | 67015 | (R)-2-((benzyloxy)methyl)-3-methylbutanoic acid | C13H18O3 | 详情 | 详情 | |
| (XXII) | 67016 | 2-((benzyloxy)methyl)-3-methylbutan-1-ol | C13H20O2 | 详情 | 详情 | |
| (XXIII) | 66991 | (R)-((2-(bromomethyl)-3-methylbutoxy)methyl)benzene | C13H19BrO | 详情 | 详情 | |
| (XXIV) | 12122 | Cyanoacetamide; 2-Cyanoacetamide | 107-91-5 | C3H4N2O | 详情 | 详情 |
| (XXVI) | 67018 | benzyl (3-amino-2,2-dimethyl-3-oxopropyl)carbamate | C13H18N2O3 | 详情 | 详情 | |
| (XXVII) | 28129 | 3-amino-2,2-dimethylpropanamide | 324763-51-1 | C5H12N2O | 详情 | 详情 |
| (XXVIII) | 28125 | tert-butyl (1S,4S)-4-[(benzyloxy)methyl]-2-hydroxy-1-[(2S)-2-[4-methoxy-3-(3-methoxypropoxy)benzyl]-3-methylbutyl]-5-methylhexylcarbamate | C37H59NO7 | 详情 | 详情 | |
| (XXIX) | 67019 | tert-butyl (6-hydroxy-8-(hydroxymethyl)-3-(4-methoxy-3-(3-methoxypropoxy)benzyl)-2,9-dimethyldecan-5-yl)carbamate | C30H53NO7 | 详情 | 详情 | |
| (XXX) | 67004 | tert-butyl (1-(4-isopropyl-5-oxotetrahydrofuran-2-yl)-3-(4-methoxy-3-(3-methoxypropoxy)benzyl)-4-methylpentyl)carbamate | C30H49NO7 | 详情 | 详情 | |
| (XXXI) | 67020 | tert-butyl (8-((1-amino-2-methyl-1-oxopropan-2-yl)carbamoyl)-6-hydroxy-3-(4-methoxy-3-(3-methoxypropoxy)benzyl)-2,9-dimethyldecan-5-yl)carbamate | C34H59N3O8 | 详情 | 详情 |
Extended Information