(3aR,4R,5R,6aS)-5-hydroxy tert-butyldimethylsilyl-4-[(E,3R)-3-hydroxy-4-[3-(trifluoromethyl)phenoxy]-1-butenyl]hexahydro-2H-cyclopenta[b]furan-2-one -Drug Synthesis Database

【结构式】

【分子编号】66886

【品名】(3aR,4R,5R,6aS)-5-hydroxy tert-butyldimethylsilyl-4-[(E,3R)-3-hydroxy-4-[3-(trifluoromethyl)phenoxy]-1-butenyl]hexahydro-2H-cyclopenta[b]furan-2-one

【CA登记号】　

【分子式】C₂₄H₃₇F₃O₅Si

【分子量】490.635

【元素组成】C 58.75% H 7.60% F 11.62% O 16.30% Si 5.72%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号：(XI)

参考文献中间体

合成目标

【1】 Gutman A, Nisnevich G, Etinger M, et aL. 2005. Process for the preparation of prostaglandin derivatives. U S Pat Appl Publ. Cont-in-part of U S Ser N0478 849. US 2005209337(本专利属于Finetech Laboratories Ltd, Israel)

中间体序号	中间体编号	品名	CAS号	分子式	供应商	用于合成
(I)	10146	Epichlorohydrin; 2-(Chloromethyl)oxirane	106-89-8	C₃H₅ClO	详情	详情
(III)	66881	1-chloro-3-(3-(trifluoromethyl)phenyl)propan-2-ol	6310-15-2	C₁₀H₁₀ClF₃O	详情	详情
(IV)	66882	1-chloro-3-(3-(trifluoromethyl)phenyl)propan-2-one		C₁₀H₈ClF₃O	详情	详情
(V)	66883	(Z)-2-(1-chloro-3-(3-(trifluoromethyl)phenyl)propan-2-ylidene)hydrazinecarboxamide		C₁₁H₁₁ClF₃N₃O	详情	详情
(VI)	66884	(Z)-dimethyl (2-(2-carbamoylhydrazono)-3-(3-(trifluoromethyl)phenyl)propyl)phosphonate		C₁₃H₁₇F₃N₃O₄P	详情	详情
(VII)	60587	dimethyl 2-oxo-3-[3-(trifluoromethyl)phenyl]propylphosphonate		C₁₂H₁₄F₃O₄P	详情	详情
(VIII)	43178	(3aR,4S,5R,6aS)-4-(hydroxymethyl)-2-oxohexahydro-2H-cyclopenta[b]furan-5-yl [1,1'-biphenyl]-4-carboxylate	31752-99-5	C₂₁H₂₀O₅	详情	详情
(IX)	32122	(3aR,4R,5R,6aS)-2-oxo-4-[(E)-3-oxo-4-[3-(trifluoromethyl)phenoxy]-1-butenyl]hexahydro-2H-cyclopenta[b]furan-5-yl [1,1'-biphenyl]-4-carboxylate		C₃₁H₂₅F₃O₆	详情	详情
(X)	66885			C₂₇H₃₄O₅Si	详情	详情
(XI)	66886	(3aR,4R,5R,6aS)-5-hydroxy tert-butyldimethylsilyl-4-[(E,3R)-3-hydroxy-4-[3-(trifluoromethyl)phenoxy]-1-butenyl]hexahydro-2H-cyclopenta[b]furan-2-one		C₂₄H₃₇F₃O₅Si	详情	详情
(XII)	66887	(Z)-7-((1S,3S,5R)-2-((E)-3-((tert-butyldimethylsilyl)oxy)-4-(3-(trifluoromethyl)phenoxy)but-1-en-1-yl)-3,5-dihydroxycyclopentyl)hept-5-enoic acid		C₂₉H₄₃F₃O₅Si	详情	详情
(XIII)	66888	(Z)-7-((1S,3S,5R)-3,5-dihydroxy-2-((E)-3-hydroxy-4-(3-(trifluoromethyl)phenoxy)but-1-en-1-yl)cyclopentyl)hept-5-enoic acid		C₂₃H₂₉F₃O₆	详情	详情
33504 (II)	33504	3-(trifluoromethyl)phenol	98-17-9	C₇H₅F₃O	详情	详情

Extended Information