【结 构 式】 ![]() |
【分子编号】66884 【品名】(Z)-dimethyl (2-(2-carbamoylhydrazono)-3-(3-(trifluoromethyl)phenyl)propyl)phosphonate 【CA登记号】 |
【 分 子 式 】C13H17F3N3O4P 【 分 子 量 】367.265 【元素组成】C 42.52% H 4.67% F 15.52% N 11.44% O 17.42% P 8.43% |
与该中间体有关的原料药合成路线共 1 条
合成路线1
该中间体在本合成路线中的序号:(VI)
【1】 Gutman A, Nisnevich G, Etinger M, et aL. 2005. Process for the preparation of prostaglandin derivatives. U S Pat Appl Publ. Cont-in-part of U S Ser N0478 849. US 2005209337(本专利属于Finetech Laboratories Ltd, Israel) |
中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
---|---|---|---|---|---|---|
(I) | 10146 | Epichlorohydrin; 2-(Chloromethyl)oxirane | 106-89-8 | C3H5ClO | 详情 | 详情 |
(III) | 66881 | 1-chloro-3-(3-(trifluoromethyl)phenyl)propan-2-ol | 6310-15-2 | C10H10ClF3O | 详情 | 详情 |
(IV) | 66882 | 1-chloro-3-(3-(trifluoromethyl)phenyl)propan-2-one | C10H8ClF3O | 详情 | 详情 | |
(V) | 66883 | (Z)-2-(1-chloro-3-(3-(trifluoromethyl)phenyl)propan-2-ylidene)hydrazinecarboxamide | C11H11ClF3N3O | 详情 | 详情 | |
(VI) | 66884 | (Z)-dimethyl (2-(2-carbamoylhydrazono)-3-(3-(trifluoromethyl)phenyl)propyl)phosphonate | C13H17F3N3O4P | 详情 | 详情 | |
(VII) | 60587 | dimethyl 2-oxo-3-[3-(trifluoromethyl)phenyl]propylphosphonate | C12H14F3O4P | 详情 | 详情 | |
(VIII) | 43178 | (3aR,4S,5R,6aS)-4-(hydroxymethyl)-2-oxohexahydro-2H-cyclopenta[b]furan-5-yl [1,1'-biphenyl]-4-carboxylate | 31752-99-5 | C21H20O5 | 详情 | 详情 |
(IX) | 32122 | (3aR,4R,5R,6aS)-2-oxo-4-[(E)-3-oxo-4-[3-(trifluoromethyl)phenoxy]-1-butenyl]hexahydro-2H-cyclopenta[b]furan-5-yl [1,1'-biphenyl]-4-carboxylate | C31H25F3O6 | 详情 | 详情 | |
(X) | 66885 | C27H34O5Si | 详情 | 详情 | ||
(XI) | 66886 | (3aR,4R,5R,6aS)-5-hydroxy tert-butyldimethylsilyl-4-[(E,3R)-3-hydroxy-4-[3-(trifluoromethyl)phenoxy]-1-butenyl]hexahydro-2H-cyclopenta[b]furan-2-one | C24H37F3O5Si | 详情 | 详情 | |
(XII) | 66887 | (Z)-7-((1S,3S,5R)-2-((E)-3-((tert-butyldimethylsilyl)oxy)-4-(3-(trifluoromethyl)phenoxy)but-1-en-1-yl)-3,5-dihydroxycyclopentyl)hept-5-enoic acid | C29H43F3O5Si | 详情 | 详情 | |
(XIII) | 66888 | (Z)-7-((1S,3S,5R)-3,5-dihydroxy-2-((E)-3-hydroxy-4-(3-(trifluoromethyl)phenoxy)but-1-en-1-yl)cyclopentyl)hept-5-enoic acid | C23H29F3O6 | 详情 | 详情 | |
33504 (II) | 33504 | 3-(trifluoromethyl)phenol | 98-17-9 | C7H5F3O | 详情 | 详情 |
Extended Information