(4aR,12aR,13R)-3,7-bis(benzyloxy)-13-(dimethylamino)-4a,6-dihydroxy-11-methyl-12a,13-dihydrotetraceno[2,3-d]isoxazole-4,5(4aH,12H)-dione -Drug Synthesis Database

【结构式】

【分子编号】66839

【品名】(4aR,12aR,13R)-3,7-bis(benzyloxy)-13-(dimethylamino)-4a,6-dihydroxy-11-methyl-12a,13-dihydrotetraceno[2,3-d]isoxazole-4,5(4aH,12H)-dione

【CA登记号】　

【分子式】C₃₆H₃₂N₂O₇

【分子量】604.659

【元素组成】C 71.51% H 5.33% N 4.63% O 18.52%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号：(VII)

【1】 Charest MG, Siegel DR, Myers AG. 2005. Synthesis of(-)-tetnccline. JAm Chem Soc, 127: 8292～8293

中间体序号	中间体编号	品名	CAS号	分子式	供应商	用于合成
(I)	10202	Benzoic acid	65-85-0	C₇H₆O₂	详情	详情
(II)	66834	(4aR,8aR,9R)-3-(benzyloxy)-9-(dimethylamino)-4a-hydroxy-8a,9-dihydronaphtho[2,3-d]isoxazole-4,5(4aH,8H)-dione		C₂₀H₂₀N₂O₅	详情	详情
(III)	66835	(4aS,8aR,9R)-3-(benzyloxy)-9-(dimethylamino)-4a-hydroxy-6-(phenylthio)-8a,9-dihydronaphtho[2,3-d]isoxazole-4,5(4aH,8H)-dione		C₂₆H₂₄N₂O₅S	详情	详情
(IV)	66836	(((7R,8R)-5-(benzyloxy)-8-methylbicyclo[4.2.0]octa-1,3,5-trien-7-yl)oxy)triethylsilane		C₂₂H₃₀O₂Si	详情	详情
(V)	66837	(4aS,5aS,6S,11S,11aR,12aR,13R)-3,7-bis(benzyloxy)-13-(dimethylamino)-4a-hydroxy-11-methyl-5a-(phenylthio)-6-((triethylsilyl)oxy)-5a,6,11a,12,12a,13-hexahydrotetraceno[2,3-d]isoxazole-4,5(4aH,11H)-dione		C₄₈H₅₄N₂O₇SSi	详情	详情
(VI)	66838	(4aS,5aS,11S,11aR,12aR,13R)-3,7-bis(benzyloxy)-13-(dimethylamino)-4a-hydroxy-11-methyl-5a-(phenylthio)-11a,12,12a,13-tetrahydrotetraceno[2,3-d]isoxazole-4,5,6(4aH,5aH,11H)-trione		C₄₂H₃₈N₂O₇S	详情	详情
(VII)	66839	(4aR,12aR,13R)-3,7-bis(benzyloxy)-13-(dimethylamino)-4a,6-dihydroxy-11-methyl-12a,13-dihydrotetraceno[2,3-d]isoxazole-4,5(4aH,12H)-dione		C₃₆H₃₂N₂O₇	详情	详情
(VIII)	66840	(4aR,11R,12aR,13R)-3,7-bis(benzyloxy)-13-(dimethylamino)-11-hydroperoxy-4a,6-dihydroxy-11-methyl-11,12,12a,13-tetrahydrotetraceno[2,3-d]isoxazole-4,5(4aH,6H)-dione		C₃₆H₃₄N₂O₉	详情	详情

Extended Information