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【结 构 式】 
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【分子编号】66837 【品名】(4aS,5aS,6S,11S,11aR,12aR,13R)-3,7-bis(benzyloxy)-13-(dimethylamino)-4a-hydroxy-11-methyl-5a-(phenylthio)-6-((triethylsilyl)oxy)-5a,6,11a,12,12a,13-hexahydrotetraceno[2,3-d]isoxazole-4,5(4aH,11H)-dione 【CA登记号】 |
【 分 子 式 】C48H54N2O7SSi 【 分 子 量 】831.118 【元素组成】C 69.37% H 6.55% N 3.37% O 13.48% S 3.86% Si 3.38% |
与该中间体有关的原料药合成路线共 1 条
合成路线1
该中间体在本合成路线中的序号：(V)
| 【1】 Charest MG, Siegel DR, Myers AG. 2005. Synthesis of(-)-tetnccline. JAm Chem Soc, 127: 8292～8293 |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 10202 | Benzoic acid | 65-85-0 | C7H6O2 | 详情 | 详情 |
| (II) | 66834 | (4aR,8aR,9R)-3-(benzyloxy)-9-(dimethylamino)-4a-hydroxy-8a,9-dihydronaphtho[2,3-d]isoxazole-4,5(4aH,8H)-dione | C20H20N2O5 | 详情 | 详情 | |
| (III) | 66835 | (4aS,8aR,9R)-3-(benzyloxy)-9-(dimethylamino)-4a-hydroxy-6-(phenylthio)-8a,9-dihydronaphtho[2,3-d]isoxazole-4,5(4aH,8H)-dione | C26H24N2O5S | 详情 | 详情 | |
| (IV) | 66836 | (((7R,8R)-5-(benzyloxy)-8-methylbicyclo[4.2.0]octa-1,3,5-trien-7-yl)oxy)triethylsilane | C22H30O2Si | 详情 | 详情 | |
| (V) | 66837 | (4aS,5aS,6S,11S,11aR,12aR,13R)-3,7-bis(benzyloxy)-13-(dimethylamino)-4a-hydroxy-11-methyl-5a-(phenylthio)-6-((triethylsilyl)oxy)-5a,6,11a,12,12a,13-hexahydrotetraceno[2,3-d]isoxazole-4,5(4aH,11H)-dione | C48H54N2O7SSi | 详情 | 详情 | |
| (VI) | 66838 | (4aS,5aS,11S,11aR,12aR,13R)-3,7-bis(benzyloxy)-13-(dimethylamino)-4a-hydroxy-11-methyl-5a-(phenylthio)-11a,12,12a,13-tetrahydrotetraceno[2,3-d]isoxazole-4,5,6(4aH,5aH,11H)-trione | C42H38N2O7S | 详情 | 详情 | |
| (VII) | 66839 | (4aR,12aR,13R)-3,7-bis(benzyloxy)-13-(dimethylamino)-4a,6-dihydroxy-11-methyl-12a,13-dihydrotetraceno[2,3-d]isoxazole-4,5(4aH,12H)-dione | C36H32N2O7 | 详情 | 详情 | |
| (VIII) | 66840 | (4aR,11R,12aR,13R)-3,7-bis(benzyloxy)-13-(dimethylamino)-11-hydroperoxy-4a,6-dihydroxy-11-methyl-11,12,12a,13-tetrahydrotetraceno[2,3-d]isoxazole-4,5(4aH,6H)-dione | C36H34N2O9 | 详情 | 详情 |
Extended Information