4-hydroxy-5-(hydroxymethyl)dihydrofuran-2(3H)-one -Drug Synthesis Database

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【结构式】

【分子编号】66772

【品名】4-hydroxy-5-(hydroxymethyl)dihydrofuran-2(3H)-one

【CA登记号】　

【分子式】C₅H₈O₄

【分子量】132.11612

【元素组成】C 45.46% H 6.1% O 48.44%

与该中间体有关的原料药合成路线共 3 条

合成路线1 合成路线2 合成路线3

合成路线1

该中间体在本合成路线中的序号： (VI)

　

参考文献中间体

【1】 Storer R. Moussa A. Wang JY. et al. 2005. Synthesis of β-L-2-deoxy-nucleosides from furanoses and pyranoses via a chloro-sugar and anhydro-l-furanosyl-nucleobase intennediatcs as potential antiviral and antineoplastic agents. W0 2005003374

中间体序号	中间体编号	品名	CAS号	分子式	供应商	用于合成
(II)	66768	(3S,5S)-3,4-dihydroxy-5-(hydroxymethyl)dihydrofuran-2(3H)-one		C₅H₈O₅	详情	详情
(VI)	66772	4-hydroxy-5-(hydroxymethyl)dihydrofuran-2(3H)-one		C₅H₈O₄	详情	详情
（X）	12204	5-Methyl-2,4(1H,3H)-pyrimidinedione; Thymine	65-71-4	C₅H₆N₂O₂	详情	详情
(I)	66767	(3S,4R,5S)tetrahydro-2H-pyran-2,3,4,5-tetrol		C₅H₁₀O₅	详情	详情
(III)	66769	3-bromo-5-(bromomethyl)-4-hydroxydihydrofuran-2(3H)-one		C₅H₆Br₂O₃	详情	详情
(IV)	66770	5-(bromomethyl)-4-hydroxydihydrofuran-2(3H)-one		C₅H₇BrO₃	详情	详情
(V)	66771	potassium 3-hydroxy-3-(oxiran-2-yl)propanoate		C₅H₇KO₄	详情	详情
(VII)	66773			C₂₁H₂₁O₆	详情	详情
(VIII)	62916	{(2S,3R)-5-hydroxy-3-[(4-methylbenzoyl)oxy]tetrahydro-2-furanyl}methyl 4-methylbenzoate		C₂₁H₂₂O₆	详情	详情
(IX)	37194	(2R,3S)-5-Chloro-2-[[(4-methylbenzoyl)oxy]methyl]tetrahydro-3-furanyl 4-methylbenzoate	4330-21-6	C₂₁H₂₁ClO₅	详情	详情
(XI)	12238	5-Methyl-1,3-bis(trimethylsilyl)-2,4(1H,3H)-pyrimidinedione	3444-09-5	C₁₁H₂₂N₂O₂Si₂	详情	详情
(XII)	62918	{(2S,3R,5S)-3-[(4-methylbenzoyl)oxy]-5-[5-methyl-2,4-dioxo-3,4-dihydro-1(2H)-pyrimidinyl]tetrahydro-2-furanyl}methyl 4-methylbenzoate		C₂₆H₂₆N₂O₇	详情	详情

合成路线2

该中间体在本合成路线中的序号：(VIII)

　

参考文献中间体

【1】 Storer R. Moussa A. Wang JY. Et al. 2005. Synthesis of β-L-2-deoxy-nucleosides from furanoses and pyranoses via a chloro-sugar and anhydro-l-furanosyl-nucleobase intennediatcs as potential antiviral and antineoplastic agents. W0 2005003374

中间体序号	中间体编号	品名	CAS号	分子式	供应商	用于合成
（X）	62916	{(2S,3R)-5-hydroxy-3-[(4-methylbenzoyl)oxy]tetrahydro-2-furanyl}methyl 4-methylbenzoate		C₂₁H₂₂O₆	详情	详情
(I)	66781	5-(1,2-dihydroxyethyl)-3,4-dihydroxydihydrofuran-2(3H)-one		C₆H₁₀O₆	详情	详情
(II)	66782	3-bromo-5-(2-bromo-1-hydroxyethyl)-4-hydroxydihydrofuran-2(3H)-one		C₆H₈Br₂O₄	详情	详情
(III)	66783	2,6-dibromo-3,4,5-trihydroxyhexanehydrazide		C₆H₁₂Br₂N₂O₄	详情	详情
(IV)	66784	5-(2-bromo-1-hydroxyethyl)-4-hydroxydihydrofuran-2(3H)-one		C₆H₉BrO₄	详情	详情
(V)	66785	potassium 3,4-dihydroxy-4-(oxiran-2-yl)butanoate		C₆H₉KO₅	详情	详情
(VI)	66786	potassium 3-hydroxy-3-(3-(hydroxymethyl)oxiran-2-yl)propanoate		C₆H₉KO₅	详情	详情
(VII)	66787	5-(1,2-dihydroxyethyl)-4-hydroxydihydrofuran-2(3H)-one		C₆H₁₀O₅	详情	详情
(VIII)	66772	4-hydroxy-5-(hydroxymethyl)dihydrofuran-2(3H)-one		C₅H₈O₄	详情	详情
(IX)	66773			C₂₁H₂₁O₆	详情	详情
(XI)	66788	3,5-bis(benzyloxy)-2-((benzyloxy)methyl)tetrahydrofuran		C₂₆H₂₈O₄	详情	详情

合成路线3

该中间体在本合成路线中的序号：(I)

　

参考文献中间体

【1】 Storer R. Moussa A. Wang JY. et al. 2005. Synthesis of β-L-2-deoxy-nucleosides from furanoses and pyranoses via a chloro-sugar and anhydro-l-furanosyl-nucleobase intennediatcs as potential antiviral and antineoplastic agents. W0 2005003374

中间体序号	中间体编号	品名	CAS号	分子式	供应商	用于合成
（III）	12204	5-Methyl-2,4(1H,3H)-pyrimidinedione; Thymine	65-71-4	C₅H₆N₂O₂	详情	详情
(I)	66772	4-hydroxy-5-(hydroxymethyl)dihydrofuran-2(3H)-one		C₅H₈O₄	详情	详情
(II)	37194	(2R,3S)-5-Chloro-2-[[(4-methylbenzoyl)oxy]methyl]tetrahydro-3-furanyl 4-methylbenzoate	4330-21-6	C₂₁H₂₁ClO₅	详情	详情
(IV)	62918	{(2S,3R,5S)-3-[(4-methylbenzoyl)oxy]-5-[5-methyl-2,4-dioxo-3,4-dihydro-1(2H)-pyrimidinyl]tetrahydro-2-furanyl}methyl 4-methylbenzoate		C₂₆H₂₆N₂O₇	详情	详情

Extended Information