(R)-tert-butyl (4-diazo-3-oxo-1-(2,4,5-trifluorophenyl)butan-2-yl)carbamate -Drug Synthesis Database

【结构式】

【分子编号】66727

【品名】(R)-tert-butyl (4-diazo-3-oxo-1-(2,4,5-trifluorophenyl)butan-2-yl)carbamate

【CA登记号】　

【分子式】C₁₅H₁₆F₃N₃O₃

【分子量】343.306

【元素组成】C 52.48% H 4.70% F 16.60% N 12.24% O 13.98%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号：(VII)

参考文献中间体

合成目标

【1】 Kim D, Wang LP, Becoru M, et al. 2005. (2R)-4-Oxo-4-[3-(Trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl}l-(2,4,5-trifluorophenyl)butan-2-amine:a potent, orally active dipeptidyl peptidase IV inhibitor for the treatment of type 2 diabetes. J Med Chem, 48(1):141～151

中间体序号	中间体编号	品名	CAS号	分子式	供应商	用于合成
(II)	66723	1-(bromomethyl)-2,4,5-trifluorobenzene		C₇H₄BrF₃	详情	详情
(I)	10296	(R)-2,5-Dihydro-3,6-dimethoxy-2-isopropylpyrazine; (3R)-3-Isopropyl-5-methoxy-3,6-dihydro-2-pyrazinyl methyl ether; (2R)-2-Isopropyl-3,6-dimethoxy-2,5-dihydropyrazine	109838-85-9	C₉H₁₆N₂O₂	详情	详情
(III)	66724	(2S,5R)-2-isopropyl-3,6-dimethoxy-5-(2,4,5-trifluorobenzyl)-2,5-dihydropyrazine		C₁₆H₁₉F₃N₂O₂	详情	详情
(IV)	66725	(R)-methyl 2-amino-3-(2,4,5-trifluorophenyl)propanoate		C₁₀H₁₀F₃NO₂	详情	详情
(V)	66729	(R)-methyl 2-((tert-butoxycarbonyl)amino)-3-(2,4,5-trifluorophenyl)propanoate		C₁₅H₁₈F₃NO₄	详情	详情
(VI)	66728	(R)-2-((tert-butoxycarbonyl)amino)-3-(2,4,5-trifluorophenyl)propanoic acid		C₁₄H₁₆F₃NO₄	详情	详情
(VII)	66727	(R)-tert-butyl (4-diazo-3-oxo-1-(2,4,5-trifluorophenyl)butan-2-yl)carbamate		C₁₅H₁₆F₃N₃O₃	详情	详情
(VIII)	66726	(R)-3-((tert-butoxycarbonyl)amino)-4-(2,4,5-trifluorophenyl)butanoic acid		C₁₅H₁₈F₃NO₄	详情	详情
(IX)	24075	2-chloropyrazine	14508-49-7	C₄H₃ClN₂	详情	详情
(X)	66713	2-Hydrazinopyrazine	54608-52-5	C₄H₆N₄	详情	详情
(XI)	66730	2,2,2-trifluoro-N'-(pyrazin-2-yl)acetohydrazide 2,2,2-trifluoroacetate		C₆H₅F₃N₄O.C₂HF₃O₂	详情	详情
(XII)	66715	3-(trifluoromethyl)-[1,2,4]triazolo[4,3-a]pyrazine		C₆H₃F₃N₄	详情	详情
(XIII)	66731	3-(trifluoromethyl)-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazine		C₆H₇F₃N₄	详情	详情
(XIV)	66732	(R)-tert-butyl (4-oxo-4-(3-(trifluoromethyl)-5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl)-1-(2,4,5-trifluorophenyl)butan-2-yl)carbamate		C₂₁H₂₃F₆N₅O₃	详情	详情

Extended Information