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【结 构 式】

【分子编号】66723

【品名】1-(bromomethyl)-2,4,5-trifluorobenzene

【CA登记号】 

【 分 子 式 】C7H4BrF3

【 分 子 量 】225.00797

【元素组成】C 37.37% H 1.79% Br 35.51% F 25.33%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号: (II)

 

1 Kim D, Wang LP, Becoru M, et al. 2005. (2R)-4-Oxo-4-[3-(Trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl}l-(2,4,5-trifluorophenyl)butan-2-amine:a potent, orally active dipeptidyl peptidase IV inhibitor for the treatment of type 2 diabetes. J Med Chem, 48(1):141~151
中间体序号 中间体编号 品名 CAS号 分子式 供应商 用于合成
(II) 66723 1-(bromomethyl)-2,4,5-trifluorobenzene   C7H4BrF3 详情 详情
(I) 10296 (R)-2,5-Dihydro-3,6-dimethoxy-2-isopropylpyrazine; (3R)-3-Isopropyl-5-methoxy-3,6-dihydro-2-pyrazinyl methyl ether; (2R)-2-Isopropyl-3,6-dimethoxy-2,5-dihydropyrazine 109838-85-9 C9H16N2O2 详情 详情
(III) 66724 (2S,5R)-2-isopropyl-3,6-dimethoxy-5-(2,4,5-trifluorobenzyl)-2,5-dihydropyrazine   C16H19F3N2O2 详情 详情
(IV) 66725 (R)-methyl 2-amino-3-(2,4,5-trifluorophenyl)propanoate   C10H10F3NO2 详情 详情
(V) 66729 (R)-methyl 2-((tert-butoxycarbonyl)amino)-3-(2,4,5-trifluorophenyl)propanoate   C15H18F3NO4 详情 详情
(VI) 66728 (R)-2-((tert-butoxycarbonyl)amino)-3-(2,4,5-trifluorophenyl)propanoic acid   C14H16F3NO4 详情 详情
(VII) 66727 (R)-tert-butyl (4-diazo-3-oxo-1-(2,4,5-trifluorophenyl)butan-2-yl)carbamate   C15H16F3N3O3 详情 详情
(VIII) 66726 (R)-3-((tert-butoxycarbonyl)amino)-4-(2,4,5-trifluorophenyl)butanoic acid   C15H18F3NO4 详情 详情
(IX) 24075 2-chloropyrazine 14508-49-7 C4H3ClN2 详情 详情
(X) 66713 2-Hydrazinopyrazine 54608-52-5 C4H6N4 详情 详情
(XI) 66730 2,2,2-trifluoro-N'-(pyrazin-2-yl)acetohydrazide 2,2,2-trifluoroacetate   C6H5F3N4O.C2HF3O2 详情 详情
(XII) 66715 3-(trifluoromethyl)-[1,2,4]triazolo[4,3-a]pyrazine   C6H3F3N4 详情 详情
(XIII) 66731 3-(trifluoromethyl)-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazine   C6H7F3N4 详情 详情
(XIV) 66732 (R)-tert-butyl (4-oxo-4-(3-(trifluoromethyl)-5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl)-1-(2,4,5-trifluorophenyl)butan-2-yl)carbamate   C21H23F6N5O3 详情 详情
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