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【结 构 式】 
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【分子编号】66684 【品名】(E)-N-(4-(4-fluorophenyl)-6-isopropyl-5-(4-oxobut-1-en-1-yl)pyrimidin-2-yl)-N-methylmethanesulfonamide 【CA登记号】 |
【 分 子 式 】C19H22FN3O3S 【 分 子 量 】391.467 【元素组成】C 58.30% H 5.66% F 4.85% N 10.73% O 12.26% S 8.19% |
与该中间体有关的原料药合成路线共 1 条
合成路线1
该中间体在本合成路线中的序号：(III)
| 【1】 Crabb JM, Horbury JT, Nigel P. 2004. An improved production of calcium salt of rosuvastatin, useful in the treatment of hypercholesterolemia, hyperlipoproteinenua, and atherosclerosis. W0 2004108691(本专利属于Astrazeneca UK Limited, UK) |
| 【2】 Huang QY. 2006. Process for preparation of Rovstatin calcium. W0 2006Q76845(本专利属于Anhui Qingrun Pharmaceutical and Chemical Co, Ltd, Peop,Rep China) |
| 【3】 Kumar Y, Meeran HNPN, De S, et aL. 2004. Process for the preparation of rosuvastatin hemicalcium salt. W0 2004052867(本专利属于Ranbaxy Labontories Limited, India) |
| 【4】 Sebek P, Radl S. Stach J. 2005. A trans-salification method for the preparation of the rosuvastatin calaum from its potassium or sodium salt. W0 2005068435(本专利属于Zentiva,A S．C,,ech Rep) |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 23882 | N-[4-(4-fluorophenyl)-5-formyl-6-isopropyl-2-pyrimidinyl]-N-methylmethanesulfonamide | 147118-37-4 | C16H18FN3O3S | 详情 | 详情 |
| (II) | 66683 | (E)-N-(5-(3-cyanoprop-1-en-1-yl)-4-(4-fluorophenyl)-6-isopropylpyrimidin-2-yl)-N-methylmethanesulfonamide | C19H21FN4O2S | 详情 | 详情 | |
| (III) | 66684 | (E)-N-(4-(4-fluorophenyl)-6-isopropyl-5-(4-oxobut-1-en-1-yl)pyrimidin-2-yl)-N-methylmethanesulfonamide | C19H22FN3O3S | 详情 | 详情 | |
| (IV) | 66685 | (S,E)-ethyl 7-(4-(4-fluorophenyl)-6-isopropyl-2-(N-methylmethylsulfonamido)pyrimidin-5-yl)-5-hydroxy-3-oxohept-6-enoate | C24H30FN3O6S | 详情 | 详情 | |
| (V) | 66686 | (3R,5S,E)-ethyl 7-(4-(4-fluorophenyl)-6-isopropyl-2-(N-methylmethylsulfonamido)pyrimidin-5-yl)-3,5-dihydroxyhept-6-enoate | C24H32FN3O6S | 详情 | 详情 |
Extended Information