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【结 构 式】

【分子编号】66683

【品名】(E)-N-(5-(3-cyanoprop-1-en-1-yl)-4-(4-fluorophenyl)-6-isopropylpyrimidin-2-yl)-N-methylmethanesulfonamide

【CA登记号】 

【 分 子 式 】C19H21FN4O2S

【 分 子 量 】388.466

【元素组成】C 58.75% H 5.45% F 4.89% N 14.42% O 8.24% S 8.25%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号:(II)

 

1 Crabb JM, Horbury JT, Nigel P. 2004. An improved production of calcium salt of rosuvastatin, useful in the treatment of hypercholesterolemia, hyperlipoproteinenua, and atherosclerosis. W0 2004108691(本专利属于Astrazeneca UK Limited, UK)
2 Huang QY. 2006. Process for preparation of Rovstatin calcium. W0 2006Q76845(本专利属于Anhui Qingrun Pharmaceutical and Chemical Co, Ltd, Peop,Rep China)
3 Kumar Y, Meeran HNPN, De S, et aL. 2004. Process for the preparation of rosuvastatin hemicalcium salt. W0 2004052867(本专利属于Ranbaxy Labontories Limited, India)
4 Sebek P, Radl S. Stach J. 2005. A trans-salification method for the preparation of the rosuvastatin calaum from its potassium or sodium salt. W0 2005068435(本专利属于Zentiva,A S.C,,ech Rep)
中间体序号 中间体编号 品名 CAS号 分子式 供应商 用于合成
(I) 23882 N-[4-(4-fluorophenyl)-5-formyl-6-isopropyl-2-pyrimidinyl]-N-methylmethanesulfonamide 147118-37-4 C16H18FN3O3S 详情 详情
(II) 66683 (E)-N-(5-(3-cyanoprop-1-en-1-yl)-4-(4-fluorophenyl)-6-isopropylpyrimidin-2-yl)-N-methylmethanesulfonamide   C19H21FN4O2S 详情 详情
(III) 66684 (E)-N-(4-(4-fluorophenyl)-6-isopropyl-5-(4-oxobut-1-en-1-yl)pyrimidin-2-yl)-N-methylmethanesulfonamide   C19H22FN3O3S 详情 详情
(IV) 66685 (S,E)-ethyl 7-(4-(4-fluorophenyl)-6-isopropyl-2-(N-methylmethylsulfonamido)pyrimidin-5-yl)-5-hydroxy-3-oxohept-6-enoate   C24H30FN3O6S 详情 详情
(V) 66686 (3R,5S,E)-ethyl 7-(4-(4-fluorophenyl)-6-isopropyl-2-(N-methylmethylsulfonamido)pyrimidin-5-yl)-3,5-dihydroxyhept-6-enoate   C24H32FN3O6S 详情 详情
Extended Information