(3R,5S,E)-(R)-2-(benzyloxy)-2-oxo-1-phenylethyl 7-(4-(4-fluorophenyl)-6-isopropyl-2-(N-methylmethylsulfonamido)pyrimidin-5-yl)-3,5-dihydroxyhept-6-enoate -Drug Synthesis Database

【结构式】

【分子编号】66678

【品名】(3R,5S,E)-(R)-2-(benzyloxy)-2-oxo-1-phenylethyl 7-(4-(4-fluorophenyl)-6-isopropyl-2-(N-methylmethylsulfonamido)pyrimidin-5-yl)-3,5-dihydroxyhept-6-enoate

【CA登记号】　

【分子式】C₃₇H₄₀FN₃O₈S

【分子量】705.804

【元素组成】C 62.96% H 5.71% F 2.69% N 5.95% O 18.13% S 4.54%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号：(III)

参考文献中间体

合成目标

【1】 Zhao ZQ，Peng LZ 2006．Preparation of Rosuvastatin and its salt. 发明专利申请公开说明书，CN(本专利属于Lunan Pharmaceutical Group Co，Ltd．Peop Rep China)

中间体序号	中间体编号	品名	分子式	供应商	用于合成
(I)	66676	(R,E)-(R)-2-(benzyloxy)-2-oxo-1-phenylethyl 3-((tert-butyldimethylsilyl)oxy)-7-(4-(4-fluorophenyl)-6-isopropyl-2-(N-methylmethylsulfonamido)pyrimidin-5-yl)-5-oxohept-6-enoate	C₄₃H₅₂FN₃O₈SSi	详情	详情
(II)	66677	(3R,5S,E)-(R)-2-(benzyloxy)-2-oxo-1-phenylethyl 3-((tert-butyldimethylsilyl)oxy)-7-(4-(4-fluorophenyl)-6-isopropyl-2-(N-methylmethylsulfonamido)pyrimidin-5-yl)-5-hydroxyhept-6-enoate	C₄₃H₅₄FN₃O₈SSi	详情	详情
(III)	66678	(3R,5S,E)-(R)-2-(benzyloxy)-2-oxo-1-phenylethyl 7-(4-(4-fluorophenyl)-6-isopropyl-2-(N-methylmethylsulfonamido)pyrimidin-5-yl)-3,5-dihydroxyhept-6-enoate	C₃₇H₄₀FN₃O₈S	详情	详情
(IV)	66679	(3R,5S,E)-7-(4-(4-fluorophenyl)-6-isopropyl-2-(N-methylmethylsulfonamido)pyrimidin-5-yl)-3,5-dihydroxyhept-6-enoic acid	C₂₂H₂₈FN₃O₆S	详情	详情

Extended Information