5-(difluoromethoxy)-1H-benzo[d]imidazole-2(3H)-thione -Drug Synthesis Database

【结构式】

【分子编号】66569

【品名】5-(difluoromethoxy)-1H-benzo[d]imidazole-2(3H)-thione

【CA登记号】97963-62-7

【分子式】C₈H₆F₂N₂OS

【分子量】216.21133

【元素组成】C 44.44% H 2.8% F 17.57% N 12.96% O 7.4% S 14.83%

与该中间体有关的原料药合成路线共 3 条

该中间体在本合成路线中的序号：(I)

【1】 Modi PA, Motiwala JK, Durlabhaji C. 1997. A process for the manufacture of 5-(difluorometboxy)-2- [[ (3,4-dimethoxy-2-pyridinyl methyl] sulfinyl] -lH-benzimidazole, i, e, the antiulcer agent pantoprazole, via oxidation of its thio analog. IN 179805(本专利属于Unichem Laboratories Ltd．India)

中间体序号	中间体编号	品名	CAS号	分子式	供应商	用于合成
(I)	66569	5-(difluoromethoxy)-1H-benzo[d]imidazole-2(3H)-thione	97963-62-7	C₈H₆F₂N₂OS	详情	详情
(II)	14035	2-(Chloromethyl)-3,4-dimethoxypyridine; 2-(Chloromethyl)-3-methoxy-4-pyridinyl methyl ether	72830-09-2	C₈H₁₀ClNO₂	详情	详情
(III)	14036	5-(Difluoromethoxy)-2-[[(3,4-dimethoxy-2-pyridinyl)methyl]sulfanyl]-1H-benzimidazole; 2-([[5-(Difluoromethoxy)-1H-benzimidazol-2-yl]sulfanyl]methyl)-3-methoxy-4-pyridinyl methyl ether	102625-64-9	C₁₆H₁₅F₂N₃O₃S	详情	详情

该中间体在本合成路线中的序号：(IV)

【1】 Palomo Coll A. 2002. A process for the preparation of pantoprazole and intermediates thereof. WO 2002028852(本专利属于Dmamite Dipharma, Italy)

中间体序号	中间体编号	品名	CAS号	分子式	供应商	用于合成
(I)	56506	4-chloro-3-methoxy-2-methyl-1-pyridiniumolate		C₇H₈ClNO₂	详情	详情
(II)	56510	(4-chloro-3-methoxy-2-pyridinyl)methanol		C₇H₈ClNO₂	详情	详情
(III)	56511	4-chloro-2-(chloromethyl)-3-methoxypyridine; 4-chloro-2-(chloromethyl)-3-pyridinyl methyl ether		C₇H₇Cl₂NO	详情	详情
(IV)	66569	5-(difluoromethoxy)-1H-benzo[d]imidazole-2(3H)-thione	97963-62-7	C₈H₆F₂N₂OS	详情	详情
(V)	56508	4-chloro-2-({[5-(difluoromethoxy)-1H-benzimidazol-2-yl]sulfanyl}methyl)-3-pyridinyl methyl ether; 2-{[(4-chloro-3-methoxy-2-pyridinyl)methyl]sulfanyl}-5-(difluoromethoxy)-1H-benzimidazole		C₁₅H₁₂ClF₂N₃O₂S	详情	详情
(VI)	56508	4-chloro-2-({[5-(difluoromethoxy)-1H-benzimidazol-2-yl]sulfanyl}methyl)-3-pyridinyl methyl ether; 2-{[(4-chloro-3-methoxy-2-pyridinyl)methyl]sulfanyl}-5-(difluoromethoxy)-1H-benzimidazole		C₁₅H₁₂ClF₂N₃O₂S	详情	详情

该中间体在本合成路线中的序号：(III)

【1】 Coppi L,Berenguer Maimo R. 2001. Method for obtaining derivatives of[[(substituted-pyridyl) methyl] thio] benzimidazole, useful as intermediates for omeprazole and related antiulcer agents. W0 2001079194 (本专利属于Esteve Quimica,S A, Spain)

中间体序号	中间体编号	品名	CAS号	分子式	供应商	用于合成
(I)	56506	4-chloro-3-methoxy-2-methyl-1-pyridiniumolate		C₇H₈ClNO₂	详情	详情
(II)	56507	(4-chloro-3-methoxy-2-pyridinyl)methyl methanesulfonate		C₈H₁₀ClNO₄S	详情	详情
(III)	66569	5-(difluoromethoxy)-1H-benzo[d]imidazole-2(3H)-thione	97963-62-7	C₈H₆F₂N₂OS	详情	详情
(IV)	56508	4-chloro-2-({[5-(difluoromethoxy)-1H-benzimidazol-2-yl]sulfanyl}methyl)-3-pyridinyl methyl ether; 2-{[(4-chloro-3-methoxy-2-pyridinyl)methyl]sulfanyl}-5-(difluoromethoxy)-1H-benzimidazole		C₁₅H₁₂ClF₂N₃O₂S	详情	详情

Extended Information