3-(2-chloroethyl)-9-hydroxy-2-methyl-6,7,8,9-tetrahydro-4H-pyrido[1,2-a]pyrimidin-4-one -Drug Synthesis Database

【结构式】

【分子编号】66561

【品名】3-(2-chloroethyl)-9-hydroxy-2-methyl-6,7,8,9-tetrahydro-4H-pyrido[1,2-a]pyrimidin-4-one

【CA登记号】130049-82-0

【分子式】C₁₁H₁₅ClN₂O₂

【分子量】242.70508

【元素组成】C 54.44% H 6.23% Cl 14.61% N 11.54% O 13.18%

与该中间体有关的原料药合成路线共 2 条

该中间体在本合成路线中的序号：(III)

【1】 Janssen CGM,Knaeps AG.Kennis LE.et aL 1989. Novel 3-piperidinyl-1,2-benzisoxazoles, EP 0368388

中间体序号	中间体编号	品名	CAS号	分子式	供应商	用于合成
(I)	37087	3-(benzyloxy)-2-pyridinylamine; 3-(benzyloxy)-2-pyridinamine	24016-03-3	C₁₂H₁₂N₂O	详情	详情
(II)	66560	3-(2-Chloroethyl)-2-methyl-9-benzyloxy-4H-pyrido[1,2-a]pyrimidin-4-one;9-Benzyloxy-3-(2-chloroethyl)-2-methyl-4H-pyrido[1,2-a]pyrimidin-4-one	147687-17-0	C₁₈H₁₇ClN₂O₂	详情	详情
(III)	66561	3-(2-chloroethyl)-9-hydroxy-2-methyl-6,7,8,9-tetrahydro-4H-pyrido[1,2-a]pyrimidin-4-one	130049-82-0	C₁₁H₁₅ClN₂O₂	详情	详情
(IV)	66562	6-fluoro-3-(piperidin-4-yl)-3a,4,5,6,7,7a-hexahydrobenzo[d]isoxazole		C₁₂H₁₉FN₂O	详情	详情

该中间体在本合成路线中的序号：(II)

【1】 Smet KD, Dun JV, Stokbroekx B.et aL 2005. Selectivity gontrol by use of near-IR for a hydrogenation process. Org Proc Res Dev,9: 344一347

中间体序号	中间体编号	品名	CAS号	分子式	供应商	用于合成
(I)	66563	3-(2-chloroethyl)-9-hydroxy-2-methyl-4H-pyrido[1,2-a]pyrimidin-4-one		C₁₁H₁₁ClN₂O₂	详情	详情
(II)	66561	3-(2-chloroethyl)-9-hydroxy-2-methyl-6,7,8,9-tetrahydro-4H-pyrido[1,2-a]pyrimidin-4-one	130049-82-0	C₁₁H₁₅ClN₂O₂	详情	详情
(III)	66564	9-hydroxy-2-methyl-3-propyl-6,7,8,9-tetrahydro-4H-pyrido[1,2-a]pyrimidin-4-one		C₁₂H₁₈N₂O₂	详情	详情
(IV)	23044	3-(2-chloroethyl)-2-methyl-6,7,8,9-tetrahydro-4H-pyrido[1,2-a]pyrimidin-4-one	63234-80-0	C₁₁H₁₅ClN₂O	详情	详情
(V)	66565	3-(2-chloroethyl)-2-methyl-6,7,8,9-tetrahydro-4H-pyrido[1,2-a]pyrimidin-4-one		C₁₁H₁₆N₂O₃	详情	详情
(VI)	66566	3-ethyl-9-hydroxy-2-methyl-4H-pyrido[1,2-a]pyrimidin-4-one		C₁₁H₁₂N₂O₂	详情	详情

Extended Information