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【结 构 式】 
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【分子编号】66474 【品名】tert-butyl(((E)-5-((3aR,4S,5S,6aR)-5-((tert-butyldimethylsilyl)oxy)-4-((3R,4S,E)-3-((tert-butyldimethylsilyl)oxy)-4-methyloct-1-en-6-yn-1-yl)hexahydropentalen-2(1H)-ylidene)pentyl)oxy)dimethylsilane 【CA登记号】 |
【 分 子 式 】C40H76O3Si3 【 分 子 量 】689.298 【元素组成】C 69.70% H 11.11% O 6.96% Si 12.22% |
与该中间体有关的原料药合成路线共 1 条
合成路线1
该中间体在本合成路线中的序号：(XIII)
| 【1】 Kramp GJ, Kim M, Gail. H-J, et aL 2005. Fully stereocontrolled total syntheses of the proetacyclin analogues 16S-iloprost and 16S-3-oxa-iloprost by a common route, using alkenylcopper-aroalke conjugate addition, asymmetric olefiMoon, and allylic alkylation. J Am Chem Soc, 127(50): 17910~17920 |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 66462 | tert-butyldimethyl(((3R,4R,E)-4-methyl-1-(tri-tert-butylstannyl)oct-1-en-6-yn-3-yl)oxy)silane | C27H54OSiSn | 详情 | 详情 | |
| (II) | 66463 | (Z)-1-((3a'S,6a'R)-5,5-dimethyl-3',3a',4',6a'-tetrahydro-1'H-spiro[[1,3]dioxane-2,2'-pentalen]-5'-yl)-2-tosyldiazene | C20H26N2O4S | 详情 | 详情 | |
| (III) | 66464 | (E)-N'-((3a'R,4'S,6a'S)-4'-((3R,4S,E)-3-((tert-butyldimethylsilyl)oxy)-4-methyloct-1-en-6-yn-1-yl)-5,5-dimethyltetrahydro-1'H-spiro[[1,3]dioxane-2,2'-pentalen]-5'(3'H)-ylidene)-4-methylbenzenesulfonohydrazide | C35H54N2O5SSi | 详情 | 详情 | |
| (IV) | 66465 | (E)-N'-((3a'R,4'S,6a'S)-4'-((3R,4S,E)-3-((tert-butyldimethylsilyl)oxy)-4-methyloct-1-en-6-yn-1-yl)-5,5-dimethyltetrahydro-1'H-spiro[[1,3]dioxane-2,2'-pentalen]-5'(3'H)-ylidene)-4-methylbenzenesulfonohydrazide | C35H52O4Si | 详情 | 详情 | |
| (V) | 66466 | (3a'R,4'S,6a'S)-4'-((3R,4S,E)-3-((tert-butyldimethylsilyl)oxy)-4-methyloct-1-en-6-yn-1-yl)-5,5-dimethyltetrahydro-1'H-spiro[[1,3]dioxane-2,2'-pentalen]-5'(3'H)-one | C28H46O4Si | 详情 | 详情 | |
| (VI) | 66467 | (3a'R,4'S,5'S,6a'S)-4'-((3R,4S,E)-3-((tert-butyldimethylsilyl)oxy)-4-methyloct-1-en-6-yn-1-yl)-5,5-dimethylhexahydro-1'H-spiro[[1,3]dioxane-2,2'-pentalen]-5'-ol | C28H48O4Si | 详情 | 详情 | |
| (VII) | 66468 | tert-butyl(((3a'R,4'S,6a'S)-4'-((3R,4S,E)-3-((tert-butyldimethylsilyl)oxy)-4-methyloct-1-en-6-yn-1-yl)-5,5-dimethylhexahydro-1'H-spiro[[1,3]dioxane-2,2'-pentalen]-5'-yl)oxy)dimethylsilane | C34H62O4Si2 | 详情 | 详情 | |
| (VIII) | 66469 | (3aR,4S,5S,6aS)-5-((tert-butyldimethylsilyl)oxy)-4-((3R,4S,E)-3-((tert-butyldimethylsilyl)oxy)-4-methyloct-1-en-6-yn-1-yl)hexahydropentalen-2(1H)-one | C29H52O3Si2 | 详情 | 详情 | |
| (IX) | 66470 | (1R)-2-(2-phenylpropan-2-yl)cyclohexyl 2-(dimethoxyphosphoryl)acetate | C19H29O5P | 详情 | 详情 | |
| (X) | 66471 | (E)-(1R)-2-(2-phenylpropan-2-yl)cyclohexyl 2-((3aR,4S,5S,6aR)-5-((tert-butyldimethylsilyl)oxy)-4-((3R,4S,E)-3-((tert-butyldimethylsilyl)oxy)-4-methyloct-1-en-6-yn-1-yl)hexahydropentalen-2(1H)-ylidene)acetate | C46H74OSi2 | 详情 | 详情 | |
| (XI) | 66472 | (E)-2-((3aR,4S,5S,6aR)-5-((tert-butyldimethylsilyl)oxy)-4-((3R,4S,E)-3-((tert-butyldimethylsilyl)oxy)-4-methyloct-1-en-6-yn-1-yl)hexahydropentalen-2(1H)-ylidene)ethanol | C31H56O3Si2 | 详情 | 详情 | |
| (XII) | 66473 | (E)-2-((3aR,4S,5S,6aR)-5-((tert-butyldimethylsilyl)oxy)-4-((3R,4S,E)-3-((tert-butyldimethylsilyl)oxy)-4-methyloct-1-en-6-yn-1-yl)hexahydropentalen-2(1H)-ylidene)ethyl acetate | C33H58O4Si2 | 详情 | 详情 | |
| (XIII) | 66474 | tert-butyl(((E)-5-((3aR,4S,5S,6aR)-5-((tert-butyldimethylsilyl)oxy)-4-((3R,4S,E)-3-((tert-butyldimethylsilyl)oxy)-4-methyloct-1-en-6-yn-1-yl)hexahydropentalen-2(1H)-ylidene)pentyl)oxy)dimethylsilane | C40H76O3Si3 | 详情 | 详情 | |
| (XIV) | 66475 | (E)-5-((3aR,4S,5S,6aR)-5-((tert-butyldimethylsilyl)oxy)-4-((3R,4S,E)-3-((tert-butyldimethylsilyl)oxy)-4-methyloct-1-en-6-yn-1-yl)hexahydropentalen-2(1H)-ylidene)pentan-1-ol | C34H62O3Si2 | 详情 | 详情 |
Extended Information