(3aR,4S,5S,6aS)-5-((tert-butyldimethylsilyl)oxy)-4-((3R,4S,E)-3-((tert-butyldimethylsilyl)oxy)-4-methyloct-1-en-6-yn-1-yl)hexahydropentalen-2(1H)-one -Drug Synthesis Database

【结构式】

【分子编号】66469

【品名】(3aR,4S,5S,6aS)-5-((tert-butyldimethylsilyl)oxy)-4-((3R,4S,E)-3-((tert-butyldimethylsilyl)oxy)-4-methyloct-1-en-6-yn-1-yl)hexahydropentalen-2(1H)-one

【CA登记号】　

【分子式】C₂₉H₅₂O₃Si₂

【分子量】504.901

【元素组成】C 68.99% H 10.38% O 9.51% Si 11.13%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号：(VIII)

参考文献中间体

合成目标

【1】 Kramp GJ, Kim M, Gail. H-J, et aL 2005. Fully stereocontrolled total syntheses of the proetacyclin analogues 16S-iloprost and 16S-3-oxa-iloprost by a common route, using alkenylcopper-aroalke conjugate addition, asymmetric olefiMoon, and allylic alkylation. J Am Chem Soc, 127(50): 17910~17920

中间体序号	中间体编号	品名	分子式	供应商	用于合成
(I)	66462	tert-butyldimethyl(((3R,4R,E)-4-methyl-1-(tri-tert-butylstannyl)oct-1-en-6-yn-3-yl)oxy)silane	C₂₇H₅₄OSiSn	详情	详情
(II)	66463	(Z)-1-((3a'S,6a'R)-5,5-dimethyl-3',3a',4',6a'-tetrahydro-1'H-spiro[[1,3]dioxane-2,2'-pentalen]-5'-yl)-2-tosyldiazene	C₂₀H₂₆N₂O₄S	详情	详情
(III)	66464	(E)-N'-((3a'R,4'S,6a'S)-4'-((3R,4S,E)-3-((tert-butyldimethylsilyl)oxy)-4-methyloct-1-en-6-yn-1-yl)-5,5-dimethyltetrahydro-1'H-spiro[[1,3]dioxane-2,2'-pentalen]-5'(3'H)-ylidene)-4-methylbenzenesulfonohydrazide	C₃₅H₅₄N₂O₅SSi	详情	详情
(IV)	66465	(E)-N'-((3a'R,4'S,6a'S)-4'-((3R,4S,E)-3-((tert-butyldimethylsilyl)oxy)-4-methyloct-1-en-6-yn-1-yl)-5,5-dimethyltetrahydro-1'H-spiro[[1,3]dioxane-2,2'-pentalen]-5'(3'H)-ylidene)-4-methylbenzenesulfonohydrazide	C₃₅H₅₂O₄Si	详情	详情
(V)	66466	(3a'R,4'S,6a'S)-4'-((3R,4S,E)-3-((tert-butyldimethylsilyl)oxy)-4-methyloct-1-en-6-yn-1-yl)-5,5-dimethyltetrahydro-1'H-spiro[[1,3]dioxane-2,2'-pentalen]-5'(3'H)-one	C₂₈H₄₆O₄Si	详情	详情
(VI)	66467	(3a'R,4'S,5'S,6a'S)-4'-((3R,4S,E)-3-((tert-butyldimethylsilyl)oxy)-4-methyloct-1-en-6-yn-1-yl)-5,5-dimethylhexahydro-1'H-spiro[[1,3]dioxane-2,2'-pentalen]-5'-ol	C₂₈H₄₈O₄Si	详情	详情
(VII)	66468	tert-butyl(((3a'R,4'S,6a'S)-4'-((3R,4S,E)-3-((tert-butyldimethylsilyl)oxy)-4-methyloct-1-en-6-yn-1-yl)-5,5-dimethylhexahydro-1'H-spiro[[1,3]dioxane-2,2'-pentalen]-5'-yl)oxy)dimethylsilane	C₃₄H₆₂O₄Si₂	详情	详情
(VIII)	66469	(3aR,4S,5S,6aS)-5-((tert-butyldimethylsilyl)oxy)-4-((3R,4S,E)-3-((tert-butyldimethylsilyl)oxy)-4-methyloct-1-en-6-yn-1-yl)hexahydropentalen-2(1H)-one	C₂₉H₅₂O₃Si₂	详情	详情
(IX)	66470	(1R)-2-(2-phenylpropan-2-yl)cyclohexyl 2-(dimethoxyphosphoryl)acetate	C₁₉H₂₉O₅P	详情	详情
(X)	66471	(E)-(1R)-2-(2-phenylpropan-2-yl)cyclohexyl 2-((3aR,4S,5S,6aR)-5-((tert-butyldimethylsilyl)oxy)-4-((3R,4S,E)-3-((tert-butyldimethylsilyl)oxy)-4-methyloct-1-en-6-yn-1-yl)hexahydropentalen-2(1H)-ylidene)acetate	C₄₆H₇₄OSi₂	详情	详情
(XI)	66472	(E)-2-((3aR,4S,5S,6aR)-5-((tert-butyldimethylsilyl)oxy)-4-((3R,4S,E)-3-((tert-butyldimethylsilyl)oxy)-4-methyloct-1-en-6-yn-1-yl)hexahydropentalen-2(1H)-ylidene)ethanol	C₃₁H₅₆O₃Si₂	详情	详情
(XII)	66473	(E)-2-((3aR,4S,5S,6aR)-5-((tert-butyldimethylsilyl)oxy)-4-((3R,4S,E)-3-((tert-butyldimethylsilyl)oxy)-4-methyloct-1-en-6-yn-1-yl)hexahydropentalen-2(1H)-ylidene)ethyl acetate	C₃₃H₅₈O₄Si₂	详情	详情
(XIII)	66474	tert-butyl(((E)-5-((3aR,4S,5S,6aR)-5-((tert-butyldimethylsilyl)oxy)-4-((3R,4S,E)-3-((tert-butyldimethylsilyl)oxy)-4-methyloct-1-en-6-yn-1-yl)hexahydropentalen-2(1H)-ylidene)pentyl)oxy)dimethylsilane	C₄₀H₇₆O₃Si₃	详情	详情
(XIV)	66475	(E)-5-((3aR,4S,5S,6aR)-5-((tert-butyldimethylsilyl)oxy)-4-((3R,4S,E)-3-((tert-butyldimethylsilyl)oxy)-4-methyloct-1-en-6-yn-1-yl)hexahydropentalen-2(1H)-ylidene)pentan-1-ol	C₃₄H₆₂O₃Si₂	详情	详情

Extended Information