ethyl 4-cyclopropyl-6,7-difluoro-5-methoxy-1-oxo-1,4-dihydronaphthalene-2-carboxylate -Drug Synthesis Database

【结构式】

【分子编号】66429

【品名】ethyl 4-cyclopropyl-6,7-difluoro-5-methoxy-1-oxo-1,4-dihydronaphthalene-2-carboxylate

【CA登记号】　

【分子式】C₁₇H₁₆F₂O₄

【分子量】322.308

【元素组成】C 63.35% H 5.00% F 11.79% O 19.86%

与该中间体有关的原料药合成路线共 2 条

该中间体在本合成路线中的序号：(I)

【1】 ChavaS 2005．An improved process for the preparation of gatifloxacin. W0 2005009970[本专利为Matrix Labomories Ltd (IN)所有]
【2】 Gomez A 2005．Process far preparing gatifloxttcin. ES. 2232309[本专利为Quinuca Sintetica, SA (ES) 所有]

中间体序号	中间体编号	品名	分子式	供应商	用于合成
(I)	66429	ethyl 4-cyclopropyl-6,7-difluoro-5-methoxy-1-oxo-1,4-dihydronaphthalene-2-carboxylate	C₁₇H₁₆F₂O₄	详情	详情
(II)	66430	6-cyclopropyl-2,2,8,9-tetrafluoro-7-methoxy-4-oxo-4,6-dihydro-2H-naphtho[1,2-d][1,3,2]dioxaborinin-1-ium-2-uide	C₁₅H₁₁BF₄O₄	详情	详情
(III)	66431	6-cyclopropyl-2,2,9-trifluoro-7-methoxy-8-(3-methylpiperazin-1-yl)-4-oxo-4,6-dihydro-2H-naphtho[1,2-d][1,3,2]dioxaborinin-1-ium-2-uide	C₂₀H₂₂BF₃N₂O₄	详情	详情

该中间体在本合成路线中的序号：(I)

【1】 Zhang C．Zhang wo. 2005．Process for preparation of(S)-Gatifloxaein．发明专利公开申请说晴书．CN 1660838(本专利申请人为:Nanjing Shenghe Pharmaceutical Co，Ltd．Peap Rep China)

中间体序号	中间体编号	品名	CAS号	分子式	供应商	用于合成
(I)	66429	ethyl 4-cyclopropyl-6,7-difluoro-5-methoxy-1-oxo-1,4-dihydronaphthalene-2-carboxylate		C₁₇H₁₆F₂O₄	详情	详情
(II)	49701	Acetic anhydride; Acetyl oxide	108-24-7	C₄H₆O₃	详情	详情
(III)	66432	2,2-diacetoxy-6-cyclopropyl-8,9-difluoro-7-methoxy-4-oxo-4,6-dihydro-2H-naphtho[1,2-d][1,3,2]dioxaborinin-1-ium-2-uide		C₁₉H₁₇BF₂O₈	详情	详情
(IV)	12267	2-Methylpiperazine	109-07-9	C₅H₁₂N₂	详情	详情

Extended Information