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【结 构 式】 
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【药物名称】Gatifloxacin, BMS-206584, CG-5501, AM-1155, Zymar, Bonoq, Gatiflo, Tequin 【化学名称】(±)-1-Cyclopropyl-6-fluoro-8-methoxy-7-(3-methyl-1-piperazinyl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid 【CA登记号】160738-57-8, 180200-66-2 (hydrate), 112811-59-3 (undefined isomer) 【 分 子 式 】C19H22FN3O4 【 分 子 量 】375.40329 |
【开发单位】Kyorin (Originator), Allergan (Licensee), Bristol-Myers Squibb (Licensee), Grünenthal (Licensee), Senju (Licensee), Dainippon Pharmaceutical (Comarketer), Lupin (Comarketer) 【药理作用】Antibacterial Drugs, Antibacterial Ophthalmic Drugs, ANTIINFECTIVE THERAPY, Ocular Antiinflammatory and Antiinfective Agents, OCULAR MEDICATIONS, Ophthalmic Drugs, DNA Gyrase Inhibitors, DNA Topoisomerase IV Inhibitors, Quinolones |
合成路线1
The reaction of 1-bromo-2,4,5-trifluoro-3-methoxybenzene (I) with CuCN and N-methyl-2-pyrrolidone at 150 C gives 2,4,5-trifluoro-3-methoxybenzonitrile (II), which by treatment with concentrated H2SO4 yields the benzamide (III). The hydrolysis of (III) with H2SO4 - water at 110 C affords 2,4,5-trifluoro-2-methoxybenzoic acid (IV), which by reaction with SOCl2 is converted into the acyl chloride (V). The condensation of (V) with diethyl malonate by means of magnesium ethoxide in toluene affords diethyl 2-(2,4,5-trifluoro-3-methoxybenzoyl)malonate (VI), which by treatment with p-toluenesulfonic acid in refluxing water gives ethyl 2-(2,4,5-trifluoro-3-methoxybenzoyl)acetate (VII). The condensation of (VII) with triethyl orthoformate in refluxing acetic anhydride yields 3-ethoxy-2-(2,4,5-trifluoro-3-methoxybenzoyl)acrylic acid ethyl ester (VIII), which is treated with cyclopropylamine (IX) to afford the corresponding cyclopropylamino derivative (X). The cyclization of (X) by means of NaF in refluxing DMF gives 1-cyclopropyl-6,7-difluoro-8-methoxy-4-oxo-1,4-dihydroquinoline-3-carboxylic acid ethyl ester (XI), which is hydrolyzed with H2SO4 in acetic acid to yield the corresponding free acid (XII). Finally, this compound is condensed with 2-methylpiperazine (XIII) in hot DMSO.
| 【1】 Masuzawa, K.; Suzue, S.; Hirai, K.; Ishizaki, T. (Kyorin Pharmaceutical Co., Ltd.); 8-Alkyoxyquinolonecarboxylic acid and salts thereof excellent in the selective toxicity and process for preparing the same. EP 0230295; JP 1987252772; JP 1994080640; JP 1994092937; JP 1995304706; JP 1995304742; US 4980470 . |
| 【2】 Prous, J.; Castaner, J.; AM-1155. Drugs Fut 1993, 18, 3, 203. |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 12255 | 3-Bromo-2,5,6-trifluorophenyl methyl ether; 1-Bromo-2,4,5-trifluoro-3-methoxybenzene | C7H4BrF3O | 详情 | 详情 | |
| (II) | 12256 | 2,4,5-Trifluoro-3-methoxybenzonitrile | C8H4F3NO | 详情 | 详情 | |
| (III) | 12257 | 2,4,5-Trifluoro-3-methoxybenzamide | C8H6F3NO2 | 详情 | 详情 | |
| (IV) | 12258 | 2,4,5-Trifluoro-3-methoxybenzoic acid | 112811-65-1 | C8H5F3O3 | 详情 | 详情 |
| (V) | 12259 | 2,4,5-Trifluoro-3-methoxybenzoyl chloride | C8H4ClF3O2 | 详情 | 详情 | |
| (VI) | 12260 | diethyl 2-(2,4,5-trifluoro-3-methoxybenzoyl)malonate | C15H15F3O6 | 详情 | 详情 | |
| (VII) | 12261 | ethyl 3-oxo-3-(2,4,5-trifluoro-3-methoxyphenyl)propanoate | C12H11F3O4 | 详情 | 详情 | |
| (VIII) | 12262 | ethyl (Z)-3-ethoxy-2-(2,4,5-trifluoro-3-methoxybenzoyl)-2-propenoate | C15H15F3O5 | 详情 | 详情 | |
| (IX) | 12263 | Cyclopropylamine; Cyclopropanamine | 765-30-0 | C3H7N | 详情 | 详情 |
| (X) | 12264 | ethyl (E)-3-(cyclopropylamino)-2-(2,4,5-trifluoro-3-methoxybenzoyl)-2-propenoate | C16H16F3NO4 | 详情 | 详情 | |
| (XI) | 12265 | ethyl 1-cyclopropyl-6,7-difluoro-8-methoxy-4-oxo-1,4-dihydro-3-quinolinecarboxylate | C16H15F2NO4 | 详情 | 详情 | |
| (XII) | 12266 | 1-Cyclopropyl-6,7-difluoro-8-methoxy-4-oxo-1,4-dihydro-3-quinolinecarboxylic acid | 112811-72-0 | C14H11F2NO4 | 详情 | 详情 |
| (XIII) | 12267 | 2-Methylpiperazine | 109-07-9 | C5H12N2 | 详情 | 详情 |
合成路线2
| 【1】 ChavaS 2005．An improved process for the preparation of gatifloxacin. W0 2005009970[本专利为Matrix Labomories Ltd (IN)所有] |
| 【2】 Gomez A 2005．Process far preparing gatifloxttcin. ES. 2232309[本专利为Quinuca Sintetica, SA (ES) 所有] |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 66429 | ethyl 4-cyclopropyl-6,7-difluoro-5-methoxy-1-oxo-1,4-dihydronaphthalene-2-carboxylate | C17H16F2O4 | 详情 | 详情 | |
| (II) | 66430 | 6-cyclopropyl-2,2,8,9-tetrafluoro-7-methoxy-4-oxo-4,6-dihydro-2H-naphtho[1,2-d][1,3,2]dioxaborinin-1-ium-2-uide | C15H11BF4O4 | 详情 | 详情 | |
| (III) | 66431 | 6-cyclopropyl-2,2,9-trifluoro-7-methoxy-8-(3-methylpiperazin-1-yl)-4-oxo-4,6-dihydro-2H-naphtho[1,2-d][1,3,2]dioxaborinin-1-ium-2-uide | C20H22BF3N2O4 | 详情 | 详情 |
合成路线3
| 【1】 Zhang C．Zhang wo. 2005．Process for preparation of(S)-Gatifloxaein．发明专利公开申请说晴书．CN 1660838(本专利申请人为:Nanjing Shenghe Pharmaceutical Co，Ltd．Peap Rep China) |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 66429 | ethyl 4-cyclopropyl-6,7-difluoro-5-methoxy-1-oxo-1,4-dihydronaphthalene-2-carboxylate | C17H16F2O4 | 详情 | 详情 | |
| (II) | 49701 | Acetic anhydride; Acetyl oxide | 108-24-7 | C4H6O3 | 详情 | 详情 |
| (III) | 66432 | 2,2-diacetoxy-6-cyclopropyl-8,9-difluoro-7-methoxy-4-oxo-4,6-dihydro-2H-naphtho[1,2-d][1,3,2]dioxaborinin-1-ium-2-uide | C19H17BF2O8 | 详情 | 详情 | |
| (IV) | 12267 | 2-Methylpiperazine | 109-07-9 | C5H12N2 | 详情 | 详情 |