N2-(3-aminopropyl)-6,7-dimethoxy-N2-methylquinazoline-2,4-diamine -Drug Synthesis Database

【结构式】

【分子编号】66069

【品名】N2-(3-aminopropyl)-6,7-dimethoxy-N2-methylquinazoline-2,4-diamine

【CA登记号】　

【分子式】C₁₄H₂₁N₅O₂

【分子量】389.45468

【元素组成】C 57.71% H 7.26% N 24.04% O 10.98%

与该中间体有关的原料药合成路线共 3 条

该中间体在本合成路线中的序号：(IX)

【1】 Joshi NS，Ramarn BP, Rao KS, et aL 2006. Processes for the preparation of alfuzosin and salts thereof and novel crystalline forms of alfuzosin W0 2006090268
【2】 Manoury PM, Binet JL, Dumas AP, et al.1986. Synthesis and antihypertensive activity of aseries of 4.amino-6,7-dimethoxyquinazoline derivativesJ Med Chem,29 1 19~25 Manoury PM, Binet JL, Dumas AP, et al.1986. Synthesis and antihypertensive activity of aseries of 4.amino-6,7-dimethoxyquinazoline derivativesJ Med Chem,29 1 19~25

中间体序号	中间体编号	品名	CAS号	分子式	供应商	用于合成
(III)	10443	2-Chloro-6,7-dimethoxy-4-quinazolinamine; 4-Amino-2-chloro-6,7-dimethoxyquinazoline; 2-Chloro-6,7-dimethoxy-4-quinazolinylamine	23680-84-4	C₁₀H₁₀ClN₃O₂	详情	详情
(IV)	24278	3-(methylamino)propanenitrile	693-05-0	C₄H₈N₂	详情	详情
(VIII)	66068	N-(4-AMINO-6,7-DIMETHOXYQUINAZOL-2-YL)-N-METHYL-2-CYANOETHYLAMINE	76362-28-2	C₁₄H₁₇N₅O₂	详情	详情
(IX)	66069	N2-(3-aminopropyl)-6,7-dimethoxy-N2-methylquinazoline-2,4-diamine		C₁₄H₂₁N₅O₂	详情	详情
(X)	66070	N-(3-((4-amino-6,7-dimethoxyquinazolin-2-yl)(methyl)amino)propyl)tetrahydrofuran-2-carboxamide		C₁₉H₂₇N₅O₄	详情	详情
(XI)	66071	Tetrahydro-2-furancarbonyl chloride	52449-98-6	C₅H₇ClO₂	详情	详情

该中间体在本合成路线中的序号：(IX)

【1】 Sadanand NS, Bhivsan AP, Chandrakantno JU, 2007.Preparation of alfuzosin. US 2007105880 Manoury PM 1982.4-Amino-6,7-dimetboxyquinazol-2-yl alkylenediamines US 4315007 Manoury PM 1982.4-Amino-6,7-dimetboxyquinazol-2-yl alkylenediamines US 4315007 Manoury PM 1982.4-Amino-6,7-dimetboxyquinazol-2-yl alkylenediamines US 4315007 Manoury PM 1982.4-Amino-6,7-dimetboxyquinazol-2-yl alkylenediamines US 4315007 Manoury PM 1982.4-Amino-6,7-dimetboxyquinazol-2-yl alkylenediamines US 4315007 Manoury PM 1982.4-Amino-6,7-dimetboxyquinazol-2-yl alkylenediamines US 4315007 Manoury PM 1982.4-Amino-6,7-dimetboxyquinazol-2-yl alkylenediamines US 4315007
【2】 Manoury PM 1982.4-Amino-6,7-dimetboxyquinazol-2-yl alkylenediamines US 4315007 Manoury PM 1982.4-Amino-6,7-dimetboxyquinazol-2-yl alkylenediamines US 4315007Manoury PM 1982.4-Amino-6,7-dimetboxyquinazol-2-yl alkylenediamines US 4315007 Manoury PM 1982.4-Amino-6,7-dimetboxyquinazol-2-yl alkylenediamines US 4315007

中间体序号	中间体编号	品名	CAS号	分子式	供应商	用于合成
(III)	10443	2-Chloro-6,7-dimethoxy-4-quinazolinamine; 4-Amino-2-chloro-6,7-dimethoxyquinazoline; 2-Chloro-6,7-dimethoxy-4-quinazolinylamine	23680-84-4	C₁₀H₁₀ClN₃O₂	详情	详情
(IV)	24278	3-(methylamino)propanenitrile	693-05-0	C₄H₈N₂	详情	详情
(VIII)	66068	N-(4-AMINO-6,7-DIMETHOXYQUINAZOL-2-YL)-N-METHYL-2-CYANOETHYLAMINE	76362-28-2	C₁₄H₁₇N₅O₂	详情	详情
(IX)	66069	N2-(3-aminopropyl)-6,7-dimethoxy-N2-methylquinazoline-2,4-diamine		C₁₄H₂₁N₅O₂	详情	详情
(X)	66070	N-(3-((4-amino-6,7-dimethoxyquinazolin-2-yl)(methyl)amino)propyl)tetrahydrofuran-2-carboxamide		C₁₉H₂₇N₅O₄	详情	详情
(XII)	52096	Tetrahydrofuran-2-carboxylic Acid; 2-Tetrahydrofuroic acid	16874-33-2	C₅H₈O₃	详情	详情

该中间体在本合成路线中的序号：(IX)

【1】 atbani PK, Narode SD,Siddiqui MJK. 2007. Process for the preparation of alfuzosin from M-(4-amino-6,7-dimethoxyquuuzolin-2-yl)-N1-methylpropylenedianune and a tetrahydro-2-furoic acid mixed an hydride W02007069050 Manoury PM 1982.4-Amino-6,7-dimetboxyquinazol-2-yl alkylenediamines US 4315007

中间体序号	中间体编号	品名	CAS号	分子式	供应商	用于合成
(IX)	66069	N2-(3-aminopropyl)-6,7-dimethoxy-N2-methylquinazoline-2,4-diamine		C₁₄H₂₁N₅O₂	详情	详情
(X)	66070	N-(3-((4-amino-6,7-dimethoxyquinazolin-2-yl)(methyl)amino)propyl)tetrahydrofuran-2-carboxamide		C₁₉H₂₇N₅O₄	详情	详情
(XII)	52096	Tetrahydrofuran-2-carboxylic Acid; 2-Tetrahydrofuroic acid	16874-33-2	C₅H₈O₃	详情	详情

Extended Information