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【结 构 式】

【分子编号】66069

【品名】N2-(3-aminopropyl)-6,7-dimethoxy-N2-methylquinazoline-2,4-diamine

【CA登记号】 

【 分 子 式 】C14H21N5O2

【 分 子 量 】389.45468

【元素组成】C 57.71% H 7.26% N 24.04% O 10.98%

与该中间体有关的原料药合成路线共 3 条

合成路线1

该中间体在本合成路线中的序号:(IX)

 

1 Joshi NS,Ramarn BP, Rao KS, et aL 2006. Processes for the preparation of alfuzosin and salts thereof and novel crystalline forms of alfuzosin W0 2006090268
2 Manoury PM, Binet JL, Dumas AP, et al.1986. Synthesis and antihypertensive activity of aseries of 4.amino-6,7-dimethoxyquinazoline derivativesJ Med Chem,29 1 19~25 Manoury PM, Binet JL, Dumas AP, et al.1986. Synthesis and antihypertensive activity of aseries of 4.amino-6,7-dimethoxyquinazoline derivativesJ Med Chem,29 1 19~25
中间体序号 中间体编号 品名 CAS号 分子式 供应商 用于合成
(III) 10443 2-Chloro-6,7-dimethoxy-4-quinazolinamine; 4-Amino-2-chloro-6,7-dimethoxyquinazoline; 2-Chloro-6,7-dimethoxy-4-quinazolinylamine 23680-84-4 C10H10ClN3O2 详情 详情
(IV) 24278 3-(methylamino)propanenitrile 693-05-0 C4H8N2 详情 详情
(VIII) 66068 N-(4-AMINO-6,7-DIMETHOXYQUINAZOL-2-YL)-N-METHYL-2-CYANOETHYLAMINE 76362-28-2 C14H17N5O2 详情 详情
(IX) 66069 N2-(3-aminopropyl)-6,7-dimethoxy-N2-methylquinazoline-2,4-diamine   C14H21N5O2 详情 详情
(X) 66070 N-(3-((4-amino-6,7-dimethoxyquinazolin-2-yl)(methyl)amino)propyl)tetrahydrofuran-2-carboxamide   C19H27N5O4 详情 详情
(XI) 66071 Tetrahydro-2-furancarbonyl chloride 52449-98-6 C5H7ClO2 详情 详情

合成路线2

该中间体在本合成路线中的序号:(IX)

 

1 Sadanand NS, Bhivsan AP, Chandrakantno JU, 2007.Preparation of alfuzosin. US 2007105880 Manoury PM 1982.4-Amino-6,7-dimetboxyquinazol-2-yl alkylenediamines US 4315007 Manoury PM 1982.4-Amino-6,7-dimetboxyquinazol-2-yl alkylenediamines US 4315007 Manoury PM 1982.4-Amino-6,7-dimetboxyquinazol-2-yl alkylenediamines US 4315007 Manoury PM 1982.4-Amino-6,7-dimetboxyquinazol-2-yl alkylenediamines US 4315007 Manoury PM 1982.4-Amino-6,7-dimetboxyquinazol-2-yl alkylenediamines US 4315007 Manoury PM 1982.4-Amino-6,7-dimetboxyquinazol-2-yl alkylenediamines US 4315007 Manoury PM 1982.4-Amino-6,7-dimetboxyquinazol-2-yl alkylenediamines US 4315007
2 Manoury PM 1982.4-Amino-6,7-dimetboxyquinazol-2-yl alkylenediamines US 4315007 Manoury PM 1982.4-Amino-6,7-dimetboxyquinazol-2-yl alkylenediamines US 4315007Manoury PM 1982.4-Amino-6,7-dimetboxyquinazol-2-yl alkylenediamines US 4315007 Manoury PM 1982.4-Amino-6,7-dimetboxyquinazol-2-yl alkylenediamines US 4315007
中间体序号 中间体编号 品名 CAS号 分子式 供应商 用于合成
(III) 10443 2-Chloro-6,7-dimethoxy-4-quinazolinamine; 4-Amino-2-chloro-6,7-dimethoxyquinazoline; 2-Chloro-6,7-dimethoxy-4-quinazolinylamine 23680-84-4 C10H10ClN3O2 详情 详情
(IV) 24278 3-(methylamino)propanenitrile 693-05-0 C4H8N2 详情 详情
(VIII) 66068 N-(4-AMINO-6,7-DIMETHOXYQUINAZOL-2-YL)-N-METHYL-2-CYANOETHYLAMINE 76362-28-2 C14H17N5O2 详情 详情
(IX) 66069 N2-(3-aminopropyl)-6,7-dimethoxy-N2-methylquinazoline-2,4-diamine   C14H21N5O2 详情 详情
(X) 66070 N-(3-((4-amino-6,7-dimethoxyquinazolin-2-yl)(methyl)amino)propyl)tetrahydrofuran-2-carboxamide   C19H27N5O4 详情 详情
(XII) 52096 Tetrahydrofuran-2-carboxylic Acid; 2-Tetrahydrofuroic acid 16874-33-2 C5H8O3 详情 详情

合成路线3

该中间体在本合成路线中的序号:(IX)

 

1 atbani PK, Narode SD,Siddiqui MJK. 2007. Process for the preparation of alfuzosin from M-(4-amino-6,7-dimethoxyquuuzolin-2-yl)-N1-methylpropylenedianune and a tetrahydro-2-furoic acid mixed an hydride W02007069050 Manoury PM 1982.4-Amino-6,7-dimetboxyquinazol-2-yl alkylenediamines US 4315007
中间体序号 中间体编号 品名 CAS号 分子式 供应商 用于合成
(IX) 66069 N2-(3-aminopropyl)-6,7-dimethoxy-N2-methylquinazoline-2,4-diamine   C14H21N5O2 详情 详情
(X) 66070 N-(3-((4-amino-6,7-dimethoxyquinazolin-2-yl)(methyl)amino)propyl)tetrahydrofuran-2-carboxamide   C19H27N5O4 详情 详情
(XII) 52096 Tetrahydrofuran-2-carboxylic Acid; 2-Tetrahydrofuroic acid 16874-33-2 C5H8O3 详情 详情
Extended Information