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【结 构 式】 
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【药物名称】Alfuzosin hydrochloride, SL-77499(free base), SL-7749910, Xatral OD, Xatral Retard, Xatral XL, Xatral SR, Alfetim, Uroxatral, Urion, Alfoten, Xatral 【化学名称】(±)-N-[3-[(4-Amino-6,7-dimethoxy-2-quinazolinyl)methylamino]propyl]tetrahydro-2-furancarboxamide monohydrochloride 【CA登记号】81403-68-1, 81403-80-7 (free base) 【 分 子 式 】C19H28ClN5O4 【 分 子 量 】425.91911 |
【开发单位】Sanofi-synthélabo (Originator), Altana Pharma (Licensee), Lorex (Licensee) 【药理作用】Benign Prostatic Hyperplasia Therapy, RENAL-UROLOGIC DRUGS, Urologic Drugs, alpha1-Adrenoceptor Antagonists |
合成路线1
| 【1】 Joshi NS，Ramarn BP, Rao KS, et aL 2006. Processes for the preparation of alfuzosin and salts thereof and novel crystalline forms of alfuzosin W0 2006090268 |
| 【2】 Manoury PM, Binet JL, Dumas AP, et al.1986. Synthesis and antihypertensive activity of aseries of 4.amino-6,7-dimethoxyquinazoline derivativesJ Med Chem,29 1 19~25 Manoury PM, Binet JL, Dumas AP, et al.1986. Synthesis and antihypertensive activity of aseries of 4.amino-6,7-dimethoxyquinazoline derivativesJ Med Chem,29 1 19~25 |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (III) | 10443 | 2-Chloro-6,7-dimethoxy-4-quinazolinamine; 4-Amino-2-chloro-6,7-dimethoxyquinazoline; 2-Chloro-6,7-dimethoxy-4-quinazolinylamine | 23680-84-4 | C10H10ClN3O2 | 详情 | 详情 |
| (IV) | 24278 | 3-(methylamino)propanenitrile | 693-05-0 | C4H8N2 | 详情 | 详情 |
| (VIII) | 66068 | N-(4-AMINO-6,7-DIMETHOXYQUINAZOL-2-YL)-N-METHYL-2-CYANOETHYLAMINE | 76362-28-2 | C14H17N5O2 | 详情 | 详情 |
| (IX) | 66069 | N2-(3-aminopropyl)-6,7-dimethoxy-N2-methylquinazoline-2,4-diamine | C14H21N5O2 | 详情 | 详情 | |
| (X) | 66070 | N-(3-((4-amino-6,7-dimethoxyquinazolin-2-yl)(methyl)amino)propyl)tetrahydrofuran-2-carboxamide | C19H27N5O4 | 详情 | 详情 | |
| (XI) | 66071 | Tetrahydro-2-furancarbonyl chloride | 52449-98-6 | C5H7ClO2 | 详情 | 详情 |
合成路线2
| 【1】 Sadanand NS, Bhivsan AP, Chandrakantno JU, 2007.Preparation of alfuzosin. US 2007105880 Manoury PM 1982.4-Amino-6,7-dimetboxyquinazol-2-yl alkylenediamines US 4315007 Manoury PM 1982.4-Amino-6,7-dimetboxyquinazol-2-yl alkylenediamines US 4315007 Manoury PM 1982.4-Amino-6,7-dimetboxyquinazol-2-yl alkylenediamines US 4315007 Manoury PM 1982.4-Amino-6,7-dimetboxyquinazol-2-yl alkylenediamines US 4315007 Manoury PM 1982.4-Amino-6,7-dimetboxyquinazol-2-yl alkylenediamines US 4315007 Manoury PM 1982.4-Amino-6,7-dimetboxyquinazol-2-yl alkylenediamines US 4315007 Manoury PM 1982.4-Amino-6,7-dimetboxyquinazol-2-yl alkylenediamines US 4315007 |
| 【2】 Manoury PM 1982.4-Amino-6,7-dimetboxyquinazol-2-yl alkylenediamines US 4315007 Manoury PM 1982.4-Amino-6,7-dimetboxyquinazol-2-yl alkylenediamines US 4315007Manoury PM 1982.4-Amino-6,7-dimetboxyquinazol-2-yl alkylenediamines US 4315007 Manoury PM 1982.4-Amino-6,7-dimetboxyquinazol-2-yl alkylenediamines US 4315007 |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (III) | 10443 | 2-Chloro-6,7-dimethoxy-4-quinazolinamine; 4-Amino-2-chloro-6,7-dimethoxyquinazoline; 2-Chloro-6,7-dimethoxy-4-quinazolinylamine | 23680-84-4 | C10H10ClN3O2 | 详情 | 详情 |
| (IV) | 24278 | 3-(methylamino)propanenitrile | 693-05-0 | C4H8N2 | 详情 | 详情 |
| (VIII) | 66068 | N-(4-AMINO-6,7-DIMETHOXYQUINAZOL-2-YL)-N-METHYL-2-CYANOETHYLAMINE | 76362-28-2 | C14H17N5O2 | 详情 | 详情 |
| (IX) | 66069 | N2-(3-aminopropyl)-6,7-dimethoxy-N2-methylquinazoline-2,4-diamine | C14H21N5O2 | 详情 | 详情 | |
| (X) | 66070 | N-(3-((4-amino-6,7-dimethoxyquinazolin-2-yl)(methyl)amino)propyl)tetrahydrofuran-2-carboxamide | C19H27N5O4 | 详情 | 详情 | |
| (XII) | 52096 | Tetrahydrofuran-2-carboxylic Acid; 2-Tetrahydrofuroic acid | 16874-33-2 | C5H8O3 | 详情 | 详情 |
合成路线3
| 【1】 atbani PK, Narode SD,Siddiqui MJK. 2007. Process for the preparation of alfuzosin from M-(4-amino-6,7-dimethoxyquuuzolin-2-yl)-N1-methylpropylenedianune and a tetrahydro-2-furoic acid mixed an hydride W02007069050 Manoury PM 1982.4-Amino-6,7-dimetboxyquinazol-2-yl alkylenediamines US 4315007 |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (IX) | 66069 | N2-(3-aminopropyl)-6,7-dimethoxy-N2-methylquinazoline-2,4-diamine | C14H21N5O2 | 详情 | 详情 | |
| (X) | 66070 | N-(3-((4-amino-6,7-dimethoxyquinazolin-2-yl)(methyl)amino)propyl)tetrahydrofuran-2-carboxamide | C19H27N5O4 | 详情 | 详情 | |
| (XII) | 52096 | Tetrahydrofuran-2-carboxylic Acid; 2-Tetrahydrofuroic acid | 16874-33-2 | C5H8O3 | 详情 | 详情 |
合成路线4
| 【1】 Anumula RR.Alla S,Gilla G.et al.2007.Process for preoration alfuzosin Via esterification oftetra-hydro-2-furoic acid followed by coupling with N-methrd-l,3-propanediamine, US 2007066824 |
| 【2】 Hu GY，Xiang HL，Xu LML 2007．PrepantionofaKuzosin发明专利申请公开说明书，CN 1935806 |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (III) | 10443 | 2-Chloro-6,7-dimethoxy-4-quinazolinamine; 4-Amino-2-chloro-6,7-dimethoxyquinazoline; 2-Chloro-6,7-dimethoxy-4-quinazolinylamine | 23680-84-4 | C10H10ClN3O2 | 详情 | 详情 |
| (X) | 66070 | N-(3-((4-amino-6,7-dimethoxyquinazolin-2-yl)(methyl)amino)propyl)tetrahydrofuran-2-carboxamide | C19H27N5O4 | 详情 | 详情 | |
| (XXIII) | 24280 | N-[3-(methylamino)propyl]tetrahydro-2-furancarboxamide;Tetrahydrofuran-2-CarboxylicAcid(3-Methylamino-Propyl)-Amide;Tetrahydrofuran-2-CarboxylicAcid(3-Methylamino-Propyl)-Amide;2-Furancarboxamide,tetrahydro-N-[3-(methylamino)propyl]- | 81403-67-0 | C9H18N2O2 | 详情 | 详情 |
合成路线5
Title compound can be prepared as follows: 1) 6,7-Dimethoxyquinazolin-2,4-dione (I) is converted to 2,4-dichloro 6,7-dimethoxyquinazoline (II), followed by selective displacement of the 4-chloro group with ammonia to give 4-amino-2-chloro-6,7-dimethoxyquinazoline (III). 2) 3-(Methylamino)propanenitrile (IV) is reacted with the mixed anhydride obtained from tetrahydrofuran-2-carboxylic acid and ethyl chloroformate to form the amide (V), which on hydrogenation over rhodium at 80 C in the presence of ammonia affords the required secondary amine (VI) via rearrangement of the initially formed primary amine (VII). Condensation of amine (VI) with 4-amino-2-chloro-6,7-dimethoxyquinazoline (III) in refluxing amyl alcohol gives alfuzosin hydrochloride.
| 【1】 Binet, J.L.; Manoury, P.M.; Dumas, A.P.; Lefevre-Borg, F.; Cavero, I.; Synthesis and antihypertensive activity of a series of 4-amino-6,7-dimethoxyquinazoline derivatives. J Med Chem 1986, 29, 19-25. |
| 【2】 Cazor, J.L.; Borg, F.; Dimsdale, M.; Alfuzosin hydrochloride. Drugs Fut 1986, 11, 10, 821. |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| 62978 | C8H12O5 | 详情 | 详情 | |||
| (I) | 24275 | 6,7-Dimethoxy-2,4(1H,3H)-quinazolinedione; 6,7-Dimethoxyquinazoline-2,4-dione | 28888-44-0 | C10H10N2O4 | 详情 | 详情 |
| (II) | 24276 | 2,4-dichloro-6-methoxy-7-quinazolinyl methyl ether | 27631-29-4 | C10H8Cl2N2O2 | 详情 | 详情 |
| (III) | 10443 | 2-Chloro-6,7-dimethoxy-4-quinazolinamine; 4-Amino-2-chloro-6,7-dimethoxyquinazoline; 2-Chloro-6,7-dimethoxy-4-quinazolinylamine | 23680-84-4 | C10H10ClN3O2 | 详情 | 详情 |
| (IV) | 24278 | 3-(methylamino)propanenitrile | 693-05-0 | C4H8N2 | 详情 | 详情 |
| (V) | 24279 | N-(2-cyanoethyl)-N-methyltetrahydro-2-furancarboxamide | C9H14N2O2 | 详情 | 详情 | |
| (VI) | 24280 | N-[3-(methylamino)propyl]tetrahydro-2-furancarboxamide;Tetrahydrofuran-2-CarboxylicAcid(3-Methylamino-Propyl)-Amide;Tetrahydrofuran-2-CarboxylicAcid(3-Methylamino-Propyl)-Amide;2-Furancarboxamide,tetrahydro-N-[3-(methylamino)propyl]- | 81403-67-0 | C9H18N2O2 | 详情 | 详情 |
| (VII) | 24281 | N-(3-aminopropyl)-N-methyltetrahydro-2-furancarboxamide | C9H18N2O2 | 详情 | 详情 |